SURFACE CROSS-LINKED LIPIDIC PARTICLES, METHODS OF PRODUCTION AND USES THEREFOR
First Claim
1. A method for producing a composition of lipidic particles with a cross-linked surface mesh, the method comprising the steps of:
- (a) preparing lipidic particles comprising pharmaceutically acceptable lipids, (b) binding hydrophilic polymer chains to the surface of the lipidic particles, and (c) cross-linking the hydrophilic polymer chains to form the cross-linked surface mesh.
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Abstract
A method for producing a composition of lipidic particles coated with a cross-linked surface mesh, the method comprising the steps of: (i) preparing lipidic particles comprising pharmaceutically acceptable lipids, (ii) binding hydrophilic polymer chains to the surface of the lipidic particles, and (iii) cross-linking the hydrophilic polymer chains to form the cross-linked surface mesh. Pharmaceutical compositions comprising surface modified lipidic particles prepared according to this method are also described. The lipidic particles resist fusion with red blood cells and platelets in vitro, and are amenable to further derivatization by targeting molecules for controlled release of component and contents, thus providing a new generation of drug carrier systems.
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Citations
21 Claims
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1. A method for producing a composition of lipidic particles with a cross-linked surface mesh, the method comprising the steps of:
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(a) preparing lipidic particles comprising pharmaceutically acceptable lipids, (b) binding hydrophilic polymer chains to the surface of the lipidic particles, and (c) cross-linking the hydrophilic polymer chains to form the cross-linked surface mesh. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A pharmaceutical composition comprising lipidic particles with a cross-linked surface mesh, the lipidic particles comprising:
- an inner lipidic particle of pharmaceutically acceptable particle-forming lipids;
hydrophilic polymer chains linked to the surface of the lipidic particle, the hydrophilic polymer chains comprising a crosslinkable end group at free ends thereof; and
cross-linker groups linking the end groups of the hydrophilic polymer chains to form the cross-linked surface mesh.
- an inner lipidic particle of pharmaceutically acceptable particle-forming lipids;
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21. A lipidic particle surface modified with a cross-linked surface mesh, the lipidic particle comprising:
- an inner lipidic particle of pharmaceutically acceptable particle-forming lipids;
hydrophilic polymer chains linked to the surface of the lipidic particle, the hydrophilic polymer chains comprising a crosslinkable end group at free ends thereof; and
cross-linker groups linking the end groups of the hydrophilic polymer chains to form the cross-linked surface mesh.
- an inner lipidic particle of pharmaceutically acceptable particle-forming lipids;
Specification