Tissue graft materials containing biocompatible agent and methods of making and using same
First Claim
1. An implantable tissue graft material comprising a collagenous tissue scaffold and a biocompatible agent bonded to the collagenous tissue scaffold via an activated photoreactive group.
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Accused Products
Abstract
The invention provides implantable tissue graft materials composed of a collagenous tissue scaffold and a biocompatible agent bonded to the tissue scaffold via an activated photoreactive group. The invention further provides methods including steps of obtaining a tissue graft material comprising a collagenous tissue scaffold; contacting the collagenous tissue scaffold with a biocompatible agent composition that includes biocompatible agent and one or more photoreactive groups; and treating the collagenous tissue scaffold and biocompatible agent composition to activate the photoreactive groups and bond the biocompatible agent to the tissue scaffold via one or more activated photoreactive groups. Implantable prostheses formed of the tissue graft material are also contemplated.
66 Citations
26 Claims
- 1. An implantable tissue graft material comprising a collagenous tissue scaffold and a biocompatible agent bonded to the collagenous tissue scaffold via an activated photoreactive group.
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15. A method comprising steps of:
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(a) obtaining a tissue graft material comprising a collagenous tissue scaffold; (b) contacting the collagenous tissue scaffold with a biocompatible agent composition comprising biocompatible agent and one or more photoreactive groups; and (c) treating the collagenous tissue scaffold and biocompatible agent composition to activate the photoreactive groups and bond the biocompatible agent to the collagenous tissue scaffold via one or more activated photoreactive groups. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22)
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23. A method comprising steps of:
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(a) obtaining a tissue graft material comprising a collagenous tissue scaffold; (b) contacting the collagenous tissue scaffold with a reagent having the formula (X)m—
Y-Z)n where X is a photoreactive group, Y is a spacer radical, and Z is a bifunctional aliphatic acid; and(c) treating the collagenous tissue scaffold and biocompatible agent composition to activate the photoreactive groups and bond the reagent to the collagenous tissue scaffold via one or more activated photoreactive groups.
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24. An implantable tissue graft material comprising a collagenous tissue scaffold and a reagent having the formula (X)m—
- Y-Z)n where X is a photoreactive group, Y is a spacer radical, and Z is a bifunctional aliphatic acid or lysine.
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25. A method comprising steps of:
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(a) obtaining a tissue graft material comprising a collagenous tissue scaffold; (b) contacting the collagenous tissue scaffold with a reagent comprising a polymeric backbone bearing one or more pendent photoreactive groups and one or more pendent bioactive groups; and (c) treating the collagenous tissue scaffold and biocompatible agent composition to activate the photoreactive groups and bond the reagent to the collagenous tissue scaffold via one or more activated photoreactive groups, wherein the bioactive groups are capable of specific, noncovalent interactions with complementary groups when the collagenous tissue scaffold is implanted in a patient.
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26. An implantable tissue graft material comprising a collagenous tissue scaffold and a reagent comprising a polymeric backbone bearing one or more pendent photoreactive groups and one or more pendent bioactive groups, wherein the bioactive groups are capable of specific, noncovalent interactions with complementary groups when the collagenous tissue scaffold is implanted in a patient.
Specification