Injectable sustained release delivery devices
First Claim
1. A drug delivery device shaped and sized for injection comprising:
- a core including one or more drugs; and
a polymeric skin at least partially surrounding the core, the skin comprising a first one or more polymers.
5 Assignments
0 Petitions
Accused Products
Abstract
An injectable drug delivery device includes a core containing one or more drugs and one or more polymers. The core may be surrounded by one or more polymer outer layers (referred to herein as “coatings,” “skins,” or “outer layers”). In certain embodiments, the device is formed by extruding or otherwise preforming a polymeric skin for a drug core. The drug core may be co-extruded with the skin, or inserted into the skin after the skin has been extruded, and possibly cured. In other embodiments, the drug core may be coated with one or more polymer coatings. These techniques may be usefully applied to fabricate devices having a wide array of drug formulations and skins that can be selected to control the release rate profile and various other properties of the drugs in the drug core in a form suitable for injection using standard or non-standard gauge needles. The device may be formed by combining at least one polymer, at least one drug, and at least one liquid solvent to form a liquid suspension or solution wherein, upon injection, such suspension or solution under goes a phase change and forms a gel. The configuration may provide for controlled release of the drug(s) for an extended period.
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Citations
78 Claims
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1. A drug delivery device shaped and sized for injection comprising:
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a core including one or more drugs; and
a polymeric skin at least partially surrounding the core, the skin comprising a first one or more polymers. - View Dependent Claims (2, 3, 31, 33)
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4-30. -30. (canceled)
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32. (canceled)
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34-45. -45. (canceled)
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46. A method comprising:
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extruding a polymeric skin;
extruding within the polymeric skin a core containing one or more drugs to provide a co-extruded mass having a core that includes the one or more drugs; and
forming the co-extruded mass into at least one drug delivery device shaped and sized for injection. - View Dependent Claims (47, 48, 57)
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49-56. -56. (canceled)
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58. A device comprising:
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a drug core containing one or more drugs, the drug core having a substantially cylindrical shape with a side wall, a first end, and a second end;
a polymeric skin surrounding the side wall of the drug core and extending beyond at least the first end of the drug core to create a reservoir;
an adhesive within the reservoir; and
an anchor adapted to secure the device after injection, the anchor partially embedded within the adhesive. - View Dependent Claims (59, 60)
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61. (canceled)
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62. A method for forming an injectable drug delivery device comprising:
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forming a polymeric skin having an interior region;
inserting a mixture into the interior region of the polymeric skin, the mixture including at least one drug;
segmenting the polymeric skin and mixture into one or more segments to provide one or more drug cores, each having a first end and a second end;
placing one of the drug cores into a polymeric sleeve that extends beyond at least the second end of the drug core to provide a reservoir; and
creating a diffusion membrane over the first end of the drug core, the diffusion membrane permeable to the at least one drug. - View Dependent Claims (63)
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64-65. -65. (canceled)
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66. A method comprising:
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extruding a polymeric skin having an interior region;
inserting one or more drugs into the interior region to provide a substantially cylindrical mass having a core that includes the one or more drugs; and
forming the cylindrical mass into at least one drug delivery device shaped and sized for injection. - View Dependent Claims (67)
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68-69. -69. (canceled)
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70. A method comprising:
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inserting a wire into an uncured polymer;
curing the polymer;
withdrawing the wire from the polymer to obtain a polymeric skin surrounding a portion of the wire;
removing the polymeric skin from the wire;
inserting one or more drugs into an interior region of the polymeric skin to provide a substantially cylindrical mass having a core that includes the one or more drugs; and
forming the cylindrical mass into at least one drug delivery device shaped and sized for injection. - View Dependent Claims (71)
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72-73. -73. (canceled)
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74. A method for treating or reducing the risk of retroviral or lentiviral infection comprising injecting a sustained release drug delivery system including an antiviral agent in a patient in need of treatment wherein a dose of said agent is released for at least 7 days.
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75. A method for treating or reducing the risk of retroviral or lentiviral infection comprising injecting a sustained release drug delivery system including an antiviral agent in a patient in need of treatment wherein release of said agent maintains a desired concentration of said agent in blood plasma for at least 7 days.
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76. A method comprising:
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forming a core including a drug;
coating the core with a polymeric skin; and
forming the core and polymeric skin into a device shaped and sized for injection. - View Dependent Claims (77)
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78-84. -84. (canceled)
Specification