Materials containing multiple layers of vesicles
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Abstract
The present invention provides a composite material, preferably an ophthalmic device, more preferably a contact lens, which comprises a vesicle-containing coating including at least one layer of a vesicle and one layer of a polyionic material having charges opposite the charges of the vesicle. Such composite material can find use in biomedical applications, for example, a device for localized drug delivery and an in vivo analyte sensor such as glucose sensing contact lens. By lifting off the vesicle-containing coating from a substrate, a self-standing membrane (film) capable of encapsulating a wide variety of guest materials can be prepared. In addition, the invention provides methods for making vesicle-containing composite and film materials of the present invention.
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Citations
20 Claims
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1-10. -10. (canceled)
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11. A method for making a composite material, comprising the steps of:
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(a) contacting a bulk material with a dispersion of a vesicle selected from the group consisting of a liposome, a polymerized liposome, a polymerized micelle, a nanocapsule having a multilayered shell of polyelectrolytes, and a microcapsule having a multilayered shell of polyelectrolytes to form a layer of the vesicle on the bulk material;
(b) optionally rinsing said bulk material by contacting said bulk material with a rinsing solution;
(c) contacting said bulk material with a solution of a polyionic material to form a layer of the polyionic material on top of the layer of the vesicle, wherein said polyionic material has charges opposite the charges of the vesicle; and
(d) optionally rinsing said bulk material by contacting said bulk material with the rinsing solution. - View Dependent Claims (12, 13, 14)
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15. A film material, comprising:
- at least one layer of a vesicle and one layer of a polyionic material having charges opposite the charges of the vesicle, wherein the vesicle is selected from the group consisting of a liposome, a liposome having a shell of polyelectrolytes, a liposome having a shell of inorganic material, a polymerized liposome, a polymerized micelle, a nanocapsule having a multilayered shell of polyelectrolytes, a microcapsule having a multilayered shell of polyelectrolytes, and combination thereof.
- View Dependent Claims (16, 17, 18)
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19. A method for making a film material containing layers of vesicle, comprising:
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(1) depositing a plurality of bilayers of a vesicle and a polyionic material having charges opposite the surface charges of the vesicle onto the surface of a substrate to a film on the substrate, wherein said vesicle is selected from the group consisting of a liposome, a polymerized micelle, a nanocapsule having a multilayered shell of polyelectrolytes, a microcapsule having a multilayered shell of polyelectrolytes, and combination thereof; and
(2) separating the film from the substrate. - View Dependent Claims (20)
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Specification