DEVICES AND METHODS FOR PHARMACOKINETIC-BASED CELL CULTURE SYSTEM
First Claim
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1. A pharmacokinetic-based microscale culture device, comprising:
- a first microscale chamber dimensioned to maintain biological material in a three-dimensional configuration under conditions that provide a value of at least one pharmacokinetic parameter in vitro that is comparable to a value of at least one pharmacokinetic parameter obtained in vivo, wherein the first microscale chamber comprises a first inlet and a first outlet for flow of fluid;
a second microscale chamber dimensioned to maintain biological material in a three-dimensional configuration under conditions that provide a value of at least one pharmacokinetic parameter in vitro that is comparable to a value of at least one pharmacokinetic parameter obtained in vivo, wherein the second microscale chamber comprises a second inlet and a second outlet for flow of fluid; and
a microfluidic channel interconnecting the first and second microscale chambers wherein the microfluidic channel is dimensioned to transport fluid.
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Abstract
Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device.
73 Citations
42 Claims
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1. A pharmacokinetic-based microscale culture device, comprising:
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a first microscale chamber dimensioned to maintain biological material in a three-dimensional configuration under conditions that provide a value of at least one pharmacokinetic parameter in vitro that is comparable to a value of at least one pharmacokinetic parameter obtained in vivo, wherein the first microscale chamber comprises a first inlet and a first outlet for flow of fluid; a second microscale chamber dimensioned to maintain biological material in a three-dimensional configuration under conditions that provide a value of at least one pharmacokinetic parameter in vitro that is comparable to a value of at least one pharmacokinetic parameter obtained in vivo, wherein the second microscale chamber comprises a second inlet and a second outlet for flow of fluid; and a microfluidic channel interconnecting the first and second microscale chambers wherein the microfluidic channel is dimensioned to transport fluid.
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- 2. A device comprising at least one microscale feature dimensioned to maintain biological material in a three-dimensional configuration under conditions that provide a value of at least one pharmacokinetic parameter in vitro that is comparable to a value of at least one pharmacokinetic parameter value found in vivo.
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18. A method of culturing biological material comprising:
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maintaining a three-dimensional configuration of biological material within a first microscale chamber under conditions that provide a value of at least one pharmacokinetic parameter in vitro that is comparable to a value of at least one pharmacokinetic parameter obtained in vivo, wherein the first microscale chamber comprises a first inlet and a first outlet for flow of fluid; maintaining a three-dimensional configuration of biological material within a second microscale chamber under conditions that provide a value of at least one pharmacokinetic parameter in vitro that is comparable to a value of at least one pharmacokinetic parameter obtained in vivo, wherein the second microscale chamber comprises a second inlet and a second outlet for flow of fluid; and interconnecting the first and second microscale chambers with a microfluidic channel wherein the microfluidic channel is dimensioned to transport fluid.
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- 19. A method comprising maintaining a three-dimensional configuration of biological material in at least one microscale feature under conditions that provide a value of at least one pharmacokinetic parameter in vitro that is comparable to a value of at least one pharmacokinetic parameter found in vivo.
- 28. A method comprising forming a microscale feature that is dimensioned to maintain biological material in a three-dimensional configuration under conditions that provide a value of at least one pharmacokinetic parameter in vitro that is comparable to a value of at least one pharmacokinetic parameter found in vivo.
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42. A device comprising:
a microscale chamber comprising a chamber geometry and a biological material and a geometry simulating parts of a living body, wherein the microscale chamber is configured to maintain the biological material in a three dimensional configuration and substantially mimic at least one measurable condition in vivo.
Specification