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PROCESS FOR THE SYNTHESIS OF OLIGONUCLEOTIDES

  • US 20080064867A1
  • Filed: 09/11/2007
  • Published: 03/13/2008
  • Est. Priority Date: 09/11/2006
  • Status: Active Grant
First Claim
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1. A method for the solid phase synthesis of oligonucleotides, wherein each synthesis cycle of the method comprises:

  • (a) cleaving a front end protective group from a nucleoside immobilized on a solid support to liberate a hydroxyl group on the nucleoside, the front end protective group comprising an acyl group, the cleaving reagent comprising an organic base selected from the group consisting of a primary amine, a secondary amine, and a mixture thereof; and

    (b) coupling an acyl protected nucleoside phosphoramidite with the hydroxyl group of the nucleoside immobilized on the solid support.

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