DEVICE AND METHOD FOR DETECTING AND TREATING CHEMICAL AND BIOLOGICAL AGENTS

• US 20080065050A1
• Filed: 05/27/2004
• Published: 03/13/2008
• Est. Priority Date: 05/27/2003
• Status: Active Grant

• Current Assignee: Integrated Sensing Systems Incorporated
• Original Assignee: Integrated Sensing Systems Incorporated
• Inventors: Sparks, Douglas Ray, Najafi, Nader
• Granted Patent: US 7,354,429 B2
• Time in Patent Office: Days
• US Class Current: 604/890.1
• CPC Class Codes: A61M 2005/14264 with means for compensating influence from the environment
• CPC Class Codes: A61M 2005/14272 for emergency, field or home use, e.g. self-contained kits to be carried by the doctor
• CPC Class Codes: A61M 25/00 Catheters; Hollow probes dilators A61M29/00; peritoneal catheters A61M1/285; tracheal tubes A61M16/04; for drainage A61M27/00; for uterus, vagina or rectum A61M31/00 ; for measuring or testing A61B; materials for catheters A61L29/00
• CPC Class Codes: A61M 5/14244 adapted to be carried by the patient, e.g. portable on the body
• CPC Class Codes: A61M 5/152 pressurised by contraction of elastic reservoirs containers for dispensing contents by contraction of an elastic bag provided therein, in general B65D83/0061
• CPC Class Codes: A61M 5/172 electrical or electronic A61M5/16804, A61M5/16831 take precedence
• CPC Class Codes: G01F 1/8409 constructional details
• CPC Class Codes: G01F 1/8445 micromachined flowmeters
• CPC Class Codes: G01F 1/8472 having curved measuring conduits, i.e. whereby the measuring conduits' curved center line lies within a plane G01F1/8481 takes precedence
• CPC Class Codes: G01F 13/006 measuring volume in function of time
• CPC Class Codes: G01F 15/003 using electromagnetic, electric or electronic means G01F15/002, G01F15/02 take precedence

Abstract

A device and method capable of sensing the presence of biochem agents, and preferably also capable of delivering precise amounts of one or more antidotes to treat a victim exposed to the agents. The device includes a freestanding tube portion having an internal passage containing a substance selective to a chemical or biological agent so that matter accumulates within the freestanding tube portion when a fluid drawn through the tube portion contains the agent. When vibrated at resonance, the resonant frequency of the tube portion is indicative of the accumulation of matter and thereby the presence of the agent to which the substance is selective. The device then preferably delivers precise amounts of one or more appropriate antidotes to treat the victim. The device is a sufficiently small and lightweight unit to permit being carried by an individual.

Claims

1. A device for detecting a chemical or biological agent and treating a person if the person is exposed to the agent, the device comprising:

a unit sufficiently small and light-weight to be carried by a person, the unit comprising at least one antidote for at least one agent selected from the group consisting of chemical and biological agents, means for selecting the at least one antidote, means for delivering the at least one antidote into the body of the person, and means for communication between the selecting means and the delivering means; and

means for detecting the presence of the at least one agent in a fluid sample near the person, the detecting means being in communication with the selecting means and operable to detect the agent in the fluid sample, identify the at least one antidote as being capable of counteracting the agent and if the agent is detected then cause the delivering means to deliver the at least one antidote into the body of the person;

wherein the delivering means comprises;

a tube comprising a freestanding tube portion through which the at least one antidote flows;

means for vibrating the freestanding tube portion of the tube at a resonant frequency thereof that varies with the density of the at least one antidote flowing therethrough, the Coriolis effect causing the freestanding tube portion to twist while being vibrated at resonance, the freestanding tube portion exhibiting a degree of twist that varies with the mass flow rate of the at least one antidote flowing therethrough;

means for sensing movement of the freestanding tube portion of the tube, the movement-sensing means producing a first output signal based on the resonant frequency of the freestanding tube portion and a second output signal based on the degree of twist of the freestanding tube portion;

means for measuring elapsed time during which the at least one antidote has flowed through the tube; and

means for stopping flow of the at least one antidote through the tube in response to either of the first and second output signals from the movement-sensing means.

3. The device according to claim 1, wherein the delivering means is operable to deliver the at least one antidote subdermally, intravenously, subcutaneously, or intramuscularly.

4. The device according to claim 1, wherein the unit comprises a plurality of antidotes and the selecting means selects among the plurality of antidotes.

5. The device according to claim 1, wherein the selecting means is operable to select more than one antidote, and the delivering means is operable to deliver the more than one antidote into the body of the person.

6. The device according to claim 1, wherein the detecting means is remote from the unit and not carried by the person.

7. The device according to claim 1, wherein the detecting means is physically coupled to the unit and carried on the person.

9. The device according to claim 1, further comprising means for measuring density of the at least one antidote.

10. The device according to claim 1, further comprising means for sending a signal indicating the location of the person.

11. The device according to claim 1, further comprising means for broadcasting an alert signal to a remote location if delivery of the at least one antidote is commenced.

12. The device according to claim 1, further comprising means for monitoring biological functions of the person, identifying biological information based on the biological functions, and sending the biological information to a remote location.

59. The device according to claim 1, wherein the detecting means comprises a substance that causes accumulation of matter when the agent is present in the fluid sample.

60. The device according to claim 1, wherein the detecting means obtains the fluid sample from the person'"'"'s surroundings.

61. The method according to claim 60, wherein the fluid sample is air.

62. The method according to claim 60, wherein the fluid sample is water.

63. The device according to claim 1, wherein the detecting means is operable to detect the type of the agent in the fluid sample.

64. The device according to claim 1, wherein the detecting means is operable to detect multiple different agents in the fluid sample and identify multiple antidotes therefor to counteract the multiple different agents.

2. (canceled)

8. A device for detecting a chemical or biological agent and treating a person if the person is exposed to the agent, the device comprising:

a unit sufficiently small and light-weight to be carried by a person, the unit comprising at least one antidote for at least one agent selected from the group consisting of chemical and biological agents, means for selecting the at least one antidote, means for delivering the at least one antidote into the body of the person, and means for communication between the selecting means and the delivering means; and

means for detecting the presence of the at least one agent in a fluid sample near the person, the detecting means being in communication with the selecting means and operable to detect the agent in the fluid sample, identify the at least one antidote as being capable of counteracting the agent and if the agent is detected then cause the delivering means to deliver the at least one antidote into the body of the person;

wherein the detecting means comprises;

a freestanding tube portion through which flows a portion of atmosphere surrounding the person, the freestanding tube portion comprising an internal passage containing a substance selective to the agent so that matter accumulates within the freestanding tube portion;

means for vibrating the freestanding tube portion at a resonant frequency thereof that varies with a combined density of the freestanding tube portion and contents of the internal passage; and

means for sensing movement of the freestanding tube portion and producing an output signal based on the resonant frequency of the freestanding tube portion, the output signal being indicative of accumulation of the matter and thereby presence of the agent in the atmosphere surrounding the person.

13-38. -38. (canceled)

39. A method of detecting a chemical or biological agent and treating a person if the person is exposed to the agent, the method comprising the steps of:

equipping the person with a unit sufficiently small and light-weight to be carried by the person, the unit comprising at least one antidote for at least one agent selected from the group consisting of chemical and biological agents, means for selecting the at least one antidote, and means for delivering the at least one antidote into the body of the person;

detecting the presence of the at least one agent in a fluid sample near the person;

if the agent is detected, sending a first signal to the selecting means;

selecting with the selecting means the at least one antidote as being capable of counteracting the agent in accordance with the first signal;

sending a second signal to the delivering means; and

then

delivering with the delivering means the at least one antidote into the body of the person in response to the second signal;

wherein the step of detecting the agent is performed on the person and with the unit, and wherein the step of detecting the agent comprises the steps of;

flowing a portion of atmosphere surrounding the person through an internal passage of a freestanding tube portion, the passage containing a substance selective to the agent so that matter accumulates within the freestanding tube portion;

vibrating the freestanding tube portion at a resonant frequency thereof that varies with a combined density of the freestanding tube portion and contents of the internal passage; and

then

sensing movement of the freestanding tube portion and producing an output signal based on the resonant frequency of the freestanding tube portion, the output signal being indicative of accumulation of the matter and thereby presence of the agent in the atmosphere surrounding the person.

41. The method according to claim 39, wherein the at least one antidote is delivered subdermally, intravenously, subcutaneously, or intramuscularly.

42. The method according to claim 39, wherein the unit comprises a plurality of antidotes and the selecting means selects among the plurality of antidotes.

43. The method according to claim 39, wherein the selecting step comprises selecting more than one antidote, and the delivering step comprises delivering the more than one antidote into the body of the person.

44. The method according to claim 39, wherein the step of detecting the agent is not performed on the person or with the unit.

47. The method according to claim 39, further comprising inserting the delivery means into the body of the person after the step of detecting the agent.

48. The method according to claim 47, wherein the step of sending the second signal to the delivering means is manually performed by the person.

49. The method according to claim 47, wherein the step of detecting the agent is not performed on the person or with the unit.

50. The method according to claim 39, wherein the step of detecting the agent occurs after inserting the delivering means into the body of the person.

51. The method according to claim 50, wherein the step of detecting the agent is performed on the person and with the unit.

52. The method according to claim 50, wherein the step of detecting the agent is not performed on the person or with the unit.

53. The method according to claim 50, wherein the steps of sending the second signal to the delivering means and delivering the at least one antidote into the body of the person are performed without intervention by the person or others.

54. The method according to claim 50, wherein the step of sending the second signal to the delivering means is manually performed by the person.

55. The method according to claim 39, further comprising measuring the density of the at least one antidote during the delivering step.

56. The method according to claim 39, further comprising sending a signal indicating the location of the person.

57. The method according to claim 39, further broadcasting an alert signal to a remote location if delivery of the at least one antidote is commenced.

58. The method according to claim 39, further comprising monitoring biological functions of the person, identifying biological information based on the biological functions, and sending the biological information to a remote location.

66. The method according to claim 39, wherein the detecting step comprises obtaining the fluid sample from the person'"'"'s surroundings.

67. The method according to claim 66, wherein the fluid sample is air.

68. The method according to claim 66, wherein the fluid sample is water.

69. The method according to claim 39, wherein the detecting steps comprises detecting the type of the agent in the fluid sample.

70. The method according to claim 39, wherein the detecting step comprises detecting multiple different agents in the fluid sample and identifying multiple antidotes therefor to counteract the multiple, different agents.

40. A method of detecting a chemical or biological agent and treating a person if the person is exposed to the agent, the method comprising the steps of:

equipping the person with a unit sufficiently small and light-weight to be carried by the person, the unit comprising at least one antidote for at least one agent selected from the group consisting of chemical and biological agents, means for selecting the at least one antidote, and means for delivering the at least one antidote into the body of the person;

detecting the presence of the at least one agent in a fluid sample near the person;

if the agent is detected, sending a first signal to the selecting means;

selecting with the selecting means the at least one antidote as being capable of counteracting the agent in accordance with the first signal;

sending a second signal to the delivering means; and

then

delivering with the delivering means the at least one antidote into the body of the person in response to the second signal;

wherein the step of delivering the at least one antidote comprises the steps of;

flowing the at least one antidote through a freestanding tube portion;

vibrating the freestanding tube portion at a resonant frequency thereof that varies with the density of the at least one antidote flowing therethrough, the Coriolis effect causing the freestanding tube portion to twist while being vibrated at resonance, the freestanding tube portion exhibiting a degree of twist that varies with the mass flow rate of the at least one antidote flowing therethrough;

sensing movement of the freestanding tube portion and producing a first output signal based on the resonant frequency of the freestanding tube portion and a second output signal based on the degree of twist of the freestanding tube portion;

measuring elapsed time during which the at least one antidote has flowed through the freestanding tube portion; and

stopping flow of the at least one antidote through the freestanding tube portion in response to a specified amount of the at least one antidote having passed through the freestanding tube portion based on the elapsed time and the second output signal.

45-46. -46. (canceled)

65. (canceled)