Bone Cement Mixing Systems and Related Methods

• US 20080065088A1
• Filed: 08/29/2007
• Published: 03/13/2008
• Est. Priority Date: 09/07/2006
• Status: Abandoned Application

• Current Assignee: Wyeth LLC (Pfizer Inc.)
• Original Assignee: Wyeth (Pfizer Inc.)
• Inventors: Cornell, Richard, Seymour, Darren, Hughes, Martin, Seeherman, Howard, Harmer, Paul, Turner, Colin
• Application Number:
  US11/846,625
• Publication Number:
  US 20080065088A1
• Time in Patent Office: Days
• US Class Current: 606/93
• CPC Class Codes: A61F 2002/2817 Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
• CPC Class Codes: A61F 2002/30601 telescopic
• CPC Class Codes: B01F 25/4512 with reciprocating pistons
• CPC Class Codes: B01F 25/4521 the components being pressed through orifices in elements, e.g. flat plates or cylinders, which obstruct the whole diameter of the tube
• CPC Class Codes: B01F 33/50112 of the syringe or cartridge type
• CPC Class Codes: B01F 35/3202 Hand driven
• CPC Class Codes: B01F 35/7163 the containers being connected in a mouth-to-mouth, end-to-end disposition, i.e. the openings are juxtaposed before contacting the contents

Abstract

Bone cement mixing systems and related methods are disclosed. The bone cement mixing systems can include a first chamber, a second chamber, and a passage fluidly connecting the first and second chambers. A first piston can be disposed in the first chamber, and a second piston can be disposed in the second chamber.

Claims

1. A bone cement mixing system, comprising:

a housing defining a first chamber, a second chamber, and a passage fluidly connecting the first and second chambers;

a first piston slidably disposed within the first chamber;

a second piston slidably disposed within the second chamber; and

a bone cement delivery device disposed within the second chamber, the bone cement delivery device defining a third chamber and being adaptable to place the third chamber in fluid communication with the first chamber.

2. The bone cement mixing system of claim 1, wherein the bone cement delivery device is disposed within a bore in the second piston.

3. The bone cement mixing system of claim 2, wherein the bone cement delivery device comprises an axially displaceable pin, the pin being arranged to fit within an aperture in a seal of the second piston such that there is substantially no fluid communication between the first chamber of the housing and the third chamber of the bone cement delivery device when the pin is disposed within the bore in the seal of the second piston.

4. The bone cement mixing system of claim 3, wherein the pin is capable of being retracted from the aperture in the seal of the second piston, the first chamber of the housing being in fluid communication with the third chamber of the bone cement delivery device when the pin is retracted from the aperture in the seal of the second piston.

5. The bone cement mixing system of claim 1, wherein the bone cement delivery device is slidably disposed within the second chamber.

6. The bone cement mixing system of claim 1, wherein the bone cement delivery device comprises a syringe.

7. The bone cement mixing system of claim 6, wherein the syringe comprises a fitting configured to secure the syringe to the second piston.

8. The bone cement mixing system of claim 7, wherein the fitting comprises a Luer Lock fitting.

9. The bone cement mixing system of claim 1, wherein the bone cement delivery device comprises a tube and circumferentially spaced ribs extending from the tube, the circumferentially spaced ribs arranged to cooperate with the second piston to form channels configured to permit gases to pass therethrough.

10. The bone cement mixing system of claim 1, wherein the passage that fluidly connects the first and second chambers has a reduced cross-sectional area relative to the first and second chambers.

11. The bone cement mixing system of claim 10, wherein a passage that fluidly connects the first and third chambers when the third chamber is placed in fluid communication with the first chamber has a reduced cross-sectional area relative to the first and third chambers.

12. The bone cement mixing system of claim 1, further comprising a bone cement powder disposed within at least one of the first and second chambers.

13. The bone cement mixing system of claim 12, wherein the bone cement powder comprises osteoconductive powder.

14. The bone cement mixing system of claim 13, wherein the bone cement powder comprises calcium phosphate/sodium bicarbonate blended powder.

15. The bone cement mixing system of claim 12, wherein the bone cement powder forms a bone cement paste when a liquid is added to the bone cement powder.

16. The bone cement mixing system of claim 15, wherein the bone cement paste can be mixed by axially displacing the first and second pistons within the first and second chambers, respectively.

17. The bone cement mixing system of claim 15, wherein the liquid comprises a solution of recombinant human bone morphogenetic protein.

18. The bone cement mixing system of claim 1, wherein the passage that fluidly connects the first and second chambers is partially defined by a mixing post and a mixing anvil extending from an inner surface of the housing.

19. The bone cement mixing system of claim 1, wherein the housing comprises an inlet fitting configured to allow a liquid injection device to be secured thereto.

20. The bone cement mixing system of claim 19, wherein the liquid injection device is in fluid communication with the first and second chambers when secured to the inlet fitting.

21. The bone cement mixing system of claim 20, wherein the bone cement mixing system is a single-use-bone cement mixing system.

22. A system, comprising:

a housing defining a first chamber, a second chamber, and a passage fluidly connecting the first and second chambers, the housing being configured so that a liquid injection device can be secured thereto, the liquid injection device being in fluid communication with at least one of the first and second chambers when secured to the housing;

a first piston slidably disposed within the first chamber;

a second piston slidably disposed within the second chamber; and

a bone cement delivery device disposed in the second chamber.

23. The system of claim 22, wherein the bone cement delivery device is disposed within a bore in the second piston.

24. The system of claim 22, further comprising a liquid injection device secured to the housing.

25. The system of claim 24, further comprising a bone cement powder disposed within at least one of the first and second chambers, wherein the bone cement powder forms a bone cement paste when a liquid is transferred from the liquid injection device into the at least one of the first and second chambers.

26. The system of claim 22, wherein the first and second pistons are capable of passing bone cement paste back and forth between the first and second chambers when the first and second pistons are alternately depressed.

27. The system of claim 22, wherein the bone cement delivery device defines a third chamber, the bone cement delivery device being adaptable to place the third chamber in fluid communication with the first chamber.

28. The system of claim 27, wherein the first piston and a plunger of the bone cement delivery device are capable of passing bone cement paste back and forth between the first and third chambers when the first piston and the plunger are alternately depressed and the third chamber of the bone cement delivery device is in fluid communication with the first chamber.

29. The system of claim 28, wherein the system is a single-use system.

30. A method, comprising:

passing a bone cement paste through a first passage that fluidly connects a first chamber and a second chamber, the first passage configured to cause a first level of shear within the bone cement paste as the bone cement paste is passed therethrough; and

passing the bone cement paste through a second passage that fluidly connects the first chamber to a third chamber, the second passage configured to cause a second level of shear within the bone cement paste as the bone cement paste is passed therethrough, the second level of shear being different than the first level of shear.

31. The method of claim 30, wherein the third chamber is formed by a bone cement delivery device disposed in the second chamber.

32. The method of claim 31, further comprising removing the bone cement delivery device from the second chamber after passing the bone cement paste into the third chamber.

33. The method of claim 30, wherein passing the bone cement paste through the first passage imparts a first level of shear to the bone cement paste and passing the bone cement paste through the second passage imparts a second level of shear to the bone cement paste, the first level of shear being lower than the second level of shear.

34. The method of claim 33, wherein the method comprises passing the bone cement paste through the first passage prior to passing the bone cement paste through the second passage.

35. The method of claim 30, further comprising introducing a liquid into at least one of the first and second chambers.

36. The method of claim 35, wherein the liquid comprises a solution of recombinant human bone morphogenetic protein.