BIFURCATED PROSTHESES HAVING DIFFERENTIAL DRUG COATINGS

• US 20080065200A1
• Filed: 09/07/2007
• Published: 03/13/2008
• Est. Priority Date: 09/07/2006
• Status: Abandoned Application

• Current Assignee: Trireme Medical Incorporated
• Original Assignee: Trireme Medical Incorporated
• Inventors: Konstantino, Eitan, Binyamin, Gary
• Application Number:
  US11/851,643
• Publication Number:
  US 20080065200A1
• Time in Patent Office: Days
• US Class Current: 623/1.35
• CPC Class Codes: A61F 2/0077 Special surfaces of prostheses, e.g. for improving ingrowth A61F2/30767 takes precedence
• CPC Class Codes: A61F 2/856 Single tubular stent with a side portal passage
• CPC Class Codes: A61F 2/915 with bands having a meander structure, adjacent bands being connected to each other
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body

Abstract

Bifurcated stent includes a main stent body and a crown adapted to deploy it laterally into a branch vessel from the main stent body. A therapeutic agent or other material is coated on at least a portion of the crown of the stent, usually over the base of the crown adjacent to the main stent body. The main stent body is either free from coating or is coated in a different manner than is the crown portion of the stent.

Claims

1. A bifurcated stent comprising:

a main stent body adapted for placement in a body lumen adjacent to a branch lumen; and

a crown on the stent body adapted to be deployed laterally outwardly from the stent body and into the branch lumen;

a coating over at least a portion of the stent, wherein a coating region over the crown of the stent differs from a coating region over the main stent body.

2. A bifurcated stent as in claim 1, wherein the stent is balloon-expandable.

3. A bifurcated stent as in claim 2, wherein the crown deploys in response to balloon expansion of the main stent body.

4. A bifurcated stent as in claim 3, wherein the crown comprises a plurality of elements which are connected to the main body so that expansion of the main body applies an opening force to the elements to cause the elements to move laterally away from an outer surface of the main body.

5. A bifurcated stent as in claim 1, wherein the stent is self-expanding.

6. A bifurcated stent as in claim 1, wherein the coating comprises a layer of a therapeutic agent deposited over an outer surface of at least a portion of the main stent and/or crown.

7. A bifurcated stent as in claim 6, wherein the layer is applied by one or more of spraying, vapor deposition, dipping, painting, ink jet coating, aerosol coating, contact printing, stamp printing, physical vapor deposition, chemical vapor deposition, electroless deposition, electrolytic deposition, sol-gel deposition, and sputteringspraying, vapor deposition, dipping, or painting.

8. A bifurcated stent as in claim 1, wherein the coating comprises a reservoir which holds a therapeutic agent.

9. A bifurcated stent as in claim 8, wherein the reservoir comprises a well in a surface of the stent.

10. A bifurcated stent as in claim 8, wherein the reservoir comprises a porous or non-porous barrier formed over the therapeutic agent.

11. A bifurcated stent as in claim 1, wherein the coating over the entire crown is coated.

12. A bifurcated stent as in claim 1, wherein the entire main stent body is free from coating.

13. A bifurcated stent as in claim 1, wherein at least a portion of the main stent body is coated with a different material or the same material in a different amount.

14. A bifurcated stent as in claim 1, wherein only a base portion of the crown is coated.

15. A bifurcated stent as in claim 14, wherein the entire main stent body is free from coating.

16. A bifurcated stent as in claim 14, wherein at least a portion of the main stent body is coated with a different material or the same material in a different amount.

18. A method as in claim 14, wherein the first therapeutic agent comprises an anti-proliferative drug and main body has no therapeutic agent.

19. A method as in claim 18, wherein the first therapeutic agent is concentrated about the base of the crown so that agent is delivered to an os of the side branch.

20. A method as in claim 18, wherein the main body is at least partially coated with a second therapeutic agent and the second therapeutic agent has a different activity or concentration than the first therapeutic agent.

17. A method for delivering a therapeutic agent to a bifurcation in a body lumen, said method comprising:

advancing a stent into the body lumen; and

deploying a crown of the stent into a side branch of the lumen while a main body of the stent remains in the body lumen;

wherein a first therapeutic agent formulation is present on the crown and the main body has a second therapeutic agent formulation or no therapeutic agent.