System and method for modulating a humoral immune

• US 20080065364A1
• Filed: 08/27/2007
• Published: 03/13/2008
• Est. Priority Date: 12/01/2004
• Status: Abandoned Application

• Current Assignee: Searete LLC (Intellectual Ventures LLC)
• Original Assignee: Searete LLC (Intellectual Ventures LLC)
• Inventors: Jung, Edward K.Y., Wilson, Richa, Myhrvold, Nathan, Wood, Lowell, Ishikawa, Muriel
• Application Number:
  US11/895,989
• Publication Number:
  US 20080065364A1
• Time in Patent Office: Days
• US Class Current: 703/11
• CPC Class Codes: G01N 33/6878 in eptitope analysis

Abstract

The present application relates, in general, to a system and/or method related to detection and/or treatment.

Claims

1. A method, comprising:

presenting one or more computable epitopes of at least one agent;

predicting one or more pattern changes in the one or more computable epitopes of the at least one agent; and

designating at least one immune response component operable for modulating (a) at least one of the one or more computable epitopes of the at least one agent or (b) at least one pattern-changed computable epitope.

5. The method of claim 1, wherein the presenting one or more computable epitopes of at least one agent comprises:

presenting at least a part of at least one of an amino acid, a protein, a lipid, a capsid protein, or a coat protein.

6. The method of claim 1, wherein the presenting one or more computable epitopes of at least one agent comprises:

presenting one or more computable epitopes with a probable mutation-susceptible region.

12. The method of claim 1, wherein the presenting one or more computable epitopes of at least one agent comprises:

presenting one or more substantially linear computable epitopes.

22. The method of claim 1, wherein the presenting one or more computable epitopes of at least one agent comprises:

providing a set of one or more computable epitopes of the at least one agent wherein the set includes at least one computable epitope having a substantially similar functional sequence match with the at least one agent.

23. The method of claim 1, wherein the presenting one or more computable epitopes of at least one agent comprises:

providing a set of one or more computable epitopes of the at least one agent wherein the set includes at least one computable epitope having a substantially similar structural match with the at least one agent.

27. The method of claim 1, wherein the predicting one or more pattern changes in the one or more computable epitopes of the at least one agent comprises:

associating the predicted one or more pattern changes in the one or more computable epitopes of the at least one agent with a predicted course of an immune response.

28. The method of claim 1, wherein the predicting one or more pattern changes in the one or more computable epitopes of the at least one agent comprises:

associating the predicted one or more pattern changes in the one or more computable epitopes with at least a part of a progression of an immune response.

29. The method of claim 1, wherein the predicting one or more pattern changes in the one or more computable epitopes of the at least one agent comprises:

predicting one or more nucleotide changes in the at least one agent.

30. The method of claim 1, wherein the predicting one or more pattern changes in the one or more computable epitopes of the at least one agent comprises:

predicting one or more amino acid changes in the at least one agent.

31. The method of claim 1, wherein the predicting one or more pattern changes in the one or more computable epitopes of the at least one agent comprises:

predicting one or more pattern changes in the structure of the at least one agent.

33. The method of claim 1, wherein the predicting one or more pattern changes in the one or more computable epitopes of the at least one agent comprises:

predicting one or more pattern changes by identifying mutational hot spots.

35. The method of claim 1, wherein the predicting one or more pattern changes in the one or more computable epitopes of the at least one agent comprises:

predicting one or more pattern changes operable for providing at least one meta-signature.

41. The method of claim 1, wherein the designating at least one immune response component further comprises:

designating at least one immune response component for modulating at least a part of an immune response.

43. The method of claim 1, wherein the designating at least one immune response component comprises:

designating at least one immune response component by providing one or more molecular sequences for forming the at least one immune response component.

46. The method of claim 1, wherein the designating at least one immune response component comprises:

designating at least a part of at least one computable epitope-specific immune response component.

47. The method of claim 1, wherein the designating at least one immune response component comprises:

designating at least a portion of a Fab region.

51. The method of claim 1, wherein the designating at least one immune response component comprises:

designating at least one paratope.

54. The method of claim 1, wherein the designating at least one immune response component comprises:

designating at least a portion of a species-dependent antibody.

55. The method of claim 1, wherein the designating at least one immune response component comprises:

designating an immune response component directed to an extracellular molecule.

57. The method of claim 1, wherein the designating at least one immune response component comprises:

designating an immune response component directed to at least one receptor.

58. The method of claim 1, wherein the designating at least one immune response component comprises:

designating an immune response component operable for binding at least a part of at least one antibody.

70. The method of claim 1, wherein the designating at least one immune response component operable for modulating (a) at least one of the one or more computable epitopes of the at least one agent or (b) at least one pattern-changed computable epitope comprises:

including data from databases for influencing the selection of the at least one immune response component.

80. The method of claim 1, wherein the predicting one or more pattern changes in the one or more computable epitopes of the at least one agent comprises:

predicting one or more pattern changes in response to input.

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170. A method related to an immune response, comprising:

predicting one or more pattern changes in one or more computable epitopes of at least one agent; and

designating at least one immune response component operable for modulating at least one of the one or more computable epitopes of the at least one agent.

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184. A method, comprising:

presenting one or more epitopes of at least one agent;

predicting one or more pattern changes in the one or more epitopes of the at least one agent; and

designating at least one immune response component operable for modulating at least one of the one or more epitopes of the at least one agent.

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