System and method for modulating a humoral immune response

• US 20080065366A1
• Filed: 09/06/2007
• Published: 03/13/2008
• Est. Priority Date: 12/01/2004
• Status: Abandoned Application

• Current Assignee: Searete LLC (Intellectual Ventures LLC)
• Original Assignee: Searete LLC (Intellectual Ventures LLC)
• Inventors: Myhrvold, Nathan, Jung, Edward, Wilson, Richa, Wood, Lowell, Ishikawa, Muriel
• Application Number:
  US11/899,592
• Publication Number:
  US 20080065366A1
• Time in Patent Office: Days
• US Class Current: 703/11
• CPC Class Codes: G01N 33/6878 in eptitope analysis

Abstract

The present application relates, in general, to a system and/or method related to detection and/or treatment.

Claims

1-173. -173. (canceled)

174. A system, comprising:

circuitry for presenting one or more antigens of at least one agent;

circuitry for predicting one or more pattern changes in the one or more antigens of the at least one agent; and

circuitry for designating at least one immune response component operable for modulating at least one of the one or more antigens of the at least one agent.

195. The system of claim 174, wherein the circuitry for presenting one or more antigens of at least one agent comprises:

circuitry for presenting one or more computable epitopes with a probable mutation-susceptible region.

196. The system of claim 174, wherein the circuitry for presenting one or more antigens of at least one agent comprises:

circuitry for providing a set of one or more computable epitopes of the at least one agent wherein the set includes at least one computable epitope having a substantially similar structural match with the at least one agent.

197. The system of claim 174, wherein the circuitry for predicting one or more pattern changes in the one or more antigens of the at least one agent comprises:

circuitry for associating the predicted one or more pattern changes in the at least one agent with a predicted course of an immune response.

198. The system of claim 174, wherein the circuitry for predicting one or more pattern changes in the one or more antigens of the at least one agent comprises:

circuitry for predicting one or more pattern changes in the structure of the at least one agent.

199. The system of claim 174, wherein the circuitry for predicting one or more pattern changes in the one or more antigens of the at least one agent comprises:

circuitry for predicting one or more pattern changes by identifying mutational hot spots.

200. The system of claim 174, wherein the circuitry for designating at least one immune response component operable for modulating at least one of the one or more antigens of the at least one agent comprises:

circuitry for designating at least one immune response component by providing one or more molecular sequences for forming the at least one immune response component.

201. The system of claim 174, wherein the circuitry for designating at least one immune response component operable for modulating at least one of the one or more antigens of the at least one agent comprises:

circuitry for designating at least one paratope.

202. The system of claim 174, wherein the circuitry for designating at least one immune response component operable for modulating at least one of the one or more antigens of the at least one agent comprises:

circuitry for including data from at least one pathogen database for influencing the selection of the at least one agent or at least one computable epitope of the at least one agent.

175. (canceled)

176. A system, comprising:

a computer readable medium including, but not limited to, a computer program for use with a computer system and wherein the computer program includes a plurality of instructions including

one or more instructions for presenting one or more antigens of at least one agent,

one or more instructions for predicting one or more pattern changes in the one or more antigens of the at least one agent, and

one or more instructions for designating at least one immune response component operable for modulating at least one of the one or more antigens of the at least one agent.

203. The system of claim 176, wherein the one or more instructions for presenting one or more antigens of at least one agent comprises:

one or more instructions for presenting one or more computable epitopes with a probable mutation-susceptible region.

204. The system of claim 176, wherein the one or more instructions for presenting one or more antigens of at least one agent comprises:

one or more instructions for providing a set of one or more computable epitopes of the at least one agent wherein the set includes at least one computable epitope having a substantially similar structural match with the at least one agent.

205. The system of claim 176, wherein the one or more instructions for predicting one or more pattern changes in the one or more antigens of the at least one agent comprises:

one or more instructions for associating the predicted one or more pattern changes with a predicted course of an immune response.

206. The system of claim 176, wherein the one or more instructions for predicting one or more pattern changes in the one or more antigens of the at least one agent comprises:

one or more instructions for predicting one or more pattern changes in the structure of the at least one agent.

207. The system of claim 176, wherein the one or more instructions for predicting one or more pattern changes in the one or more antigens of the at least one agent comprises:

one or more instructions for predicting one or more pattern changes by identifying mutational hot spots.

208. The system of claim 176, wherein the one or more instructions for designating at least one immune response component operable for modulating at least one of the one or more antigens of the at least one agent comprises:

one or more instructions for designating at least one immune response component by providing one or more molecular sequences for forming the at least one immune response component.

209. The system of claim 176, wherein the one or more instructions for designating at least one immune response component operable for modulating at least one of the one or more antigens of the at least one agent comprises:

one or more instructions for designating at least one paratope.

210. The system of claim 176, wherein the one or more instructions for designating at least one immune response component operable for modulating at least one of the one or more antigens of the at least one agent comprises:

one or more instructions for including data from at least one pathogen database for influencing the selection of the at least one agent or at least one computable epitope of the at least one agent.

177. (canceled)

178. (canceled)

179. (canceled)

180. (canceled)

181. (canceled)

182. A system related to an immune response, comprising:

circuitry for predicting one or more pattern changes in one or more antigens of at least one agent; and

circuitry for designating at least one immune response component operable for modulating at least one of the one or more antigens of the at least one agent.

211. The system of claim 182, wherein the circuitry for predicting one or more pattern changes in one or more antigens of at least one agent comprises:

circuitry for associating the predicted one or more pattern changes with a predicted course of an immune response.

212. The system of claim 182, wherein the circuitry for predicting one or more pattern changes in one or more antigens of at least one agent comprises:

circuitry for predicting one or more pattern changes in the structure of the at least one agent.

213. The system of claim 182, wherein the circuitry for predicting one or more pattern changes in one or more antigens of at least one agent comprises:

circuitry for predicting one or more pattern changes by identifying mutational hot spots.

214. The system of claim 182, wherein the circuitry for designating at least one immune response component operable for modulating at least one of the one or more antigens of the at least one agent comprises:

circuitry for designating at least one immune response component by providing one or more molecular sequences for forming the at least one immune response component.

215. The system of claim 182, wherein the circuitry for designating at least one immune response component operable for modulating at least one of the one or more antigens of the at least one agent comprises:

circuitry for designating at least one paratope.

216. The system of claim 182, wherein the circuitry for designating at least one immune response component operable for modulating at least one of the one or more antigens of the at least one agent comprises:

circuitry for including data from at least one pathogen database for influencing the selection of the at least one agent or at least one computable epitope of the at least one agent.

183-194. -194. (canceled)