Selective resonant reconfiguration of chemical structures

• US 20080069738A1
• Filed: 09/24/2007
• Published: 03/20/2008
• Est. Priority Date: 07/21/2005
• Status: Active Grant

• Current Assignee: Enterprise Science Fund, LLC (Intellectual Ventures LLC)
• Original Assignee: Searete LLC (Intellectual Ventures LLC)
• Inventors: Jung, Edward, Leuthardt, Eric, Myhrvold, Nathan, Wood, Lowell, Ishikawa, Muriel
• Granted Patent: US 8,386,183 B2
• Time in Patent Office: Days
• US Class Current: 422/105
• CPC Class Codes: A61K 31/4743 condensed with ring systems having sulfur as a ring hetero atom
• CPC Class Codes: A61K 41/0004 Homeopathy; Vitalisation; Resonance; Dynamisation, e.g. esoteric applications; Oxygenation of blood
• CPC Class Codes: A61N 1/306 Arrangements where at least part of the apparatus is introduced into the body
• CPC Class Codes: A61N 2/00 Magnetotherapy
• CPC Class Codes: B01J 19/12 employing electromagnetic waves
• CPC Class Codes: B01J 19/121 Coherent waves, e.g. laser beams lasers per se H01S3/00
• CPC Class Codes: C07K 1/00 General methods for the preparation of peptides , i.e. processes for the organic chemical preparation of peptides or proteins of any length
• CPC Class Codes: C07K 2299/00 Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Abstract

Chemical compositions may be selectively or preferentially excited by the application of scores comprising a series of energy inputs.

Claims

1. A method for applying energy to a selected group of proximate atoms within a medium, the method comprising:

selecting a score specifying a series of differing energy inputs, the differing energy inputs of the specified series selected to resonate each resonant structure of a plurality of resonant structures among the group of proximate atoms; and

applying the series of differing energy inputs specified by the score to the medium with respective parameters selected to change at least a subset of the group of proximate atoms from a first geometric configuration to a second geometric configuration different from the first geometric configuration.

2. The method of claim 1, wherein the first geometric configuration and the second geometric configuration are stereoisomers.

3. The method of claim 1, wherein the score is selected such that the applied series of differing energy inputs has a physical effect selected from the group consisting of:

transferring substantially more energy to the at least a portion of the group of proximate atoms than to atoms in the medium that are not part of the group of proximate atoms;

breaking a predetermined bond between two members of the group of proximate atoms; and

changing a kinetic parameter of a reaction involving a member of the group of proximate atoms.

4. The method of claim 1, wherein transfer of energy to the medium is predominantly through resonant excitation of the plurality of resonant structures.

8. The method of claim 1, wherein the series of differing energy inputs are applied simultaneously.

9. The method of claim 1, wherein the series of differing energy inputs are applied sequentially.

10. The method of claim 1, wherein the series of differing energy inputs are applied in a temporally overlapping fashion.

11. The method of claim 1, wherein the group of proximate atoms forms at least a portion of a molecule.

12. The method of claim 11, wherein the molecule is a biomolecule.

13. The method of claim 12, wherein the biomolecule is a protein or a nucleotide.

14. The method of claim 12, wherein the biomolecule is a therapeutic agent.

21. The method of claim 1, wherein the score comprises at least 4 energy inputs.

22. The method of claim 1, wherein the score comprises at least 10 energy inputs.

23. The method of claim 1, wherein the score comprises at least 36 energy inputs.

24. The method of claim 1, wherein the plurality of resonant structures comprises a longitudinal vibrational mode of a bond.

25. The method of claim 1, wherein the plurality of resonant structures comprises a bending mode of two bonds to a member of the group of proximate atoms.

26. The method of claim 1, wherein the plurality of resonant strictures comprises a squashing mode of a plurality of bonds between members of the group of proximate atoms.

27. The method of claim 1, wherein the score specifies application of an electromagnetic beam as an energy input.

44. The method of claim 27, further comprising scanning the electromagnetic beam.

45. The method of claim 1, wherein at least one energy input comprises a plurality of electromagnetic beams.

47. The method of claim 45, wherein the plurality of electromagnetic beams intersect at a target location.

48. The method of claim 1, further comprising applying a field to the medium, wherein the field acts to preferentially orient at least a portion of the group of proximate atoms.

50. The method of claim 1, wherein:

the plurality of resonant structures are in an arrangement having two end resonant structures and a center resonant structure; and

the plurality of resonant structures are resonated in a sequence beginning from the two end resonant structures and progressing towards the center resonant structure.

51. The method of claim 50, wherein the group of proximate atoms undergoes a physical effect upon resonance of the center structure.

52. The method of claim 50, wherein resonance of the center structure breaks a predetermined bond between two members of the group of proximate atoms.

5-7. -7. (canceled)

15-20. -20. (canceled)

28-43. -43. (canceled)

46. (canceled)

49. (canceled)

53. (canceled)

54. A method of exciting a composition including a plurality of resonant structures, each resonant structure having a respective resonant frequency, the method comprising:

selecting a set of excitation energies, each excitation energy having a respective amplitude and a respective frequency corresponding to the resonant frequency of at least one of the resonant structures of the plurality; and

applying the set of excitation energies to the composition, wherein;

the set of excitation energies, applied together, are selected to induce the composition to change from a first stereoisomer to a second stereoisomer; and

any one of the excitation energies, applied at its respective amplitude in the absence of the other members of the set, would not induce a substantial change from the first stereoisomer to the second stereoisomer.

55. The method of claim 54, wherein the frequency is a modulation frequency.

56. The method of claim 54, wherein the excitation energies are applied simultaneously.

57. The method of claim 54, wherein the excitation energies are applied sequentially.

58. The method of claim 54, wherein the excitation energies are applied in a temporally overlapping fashion.

59. The method of claim 54, wherein the composition is a biomolecule.

60. The method of claim 59, wherein the biomolecule is a protein or a nucleotide.

61. The method of claim 59, wherein the biomolecule is a therapeutic agent.

68. The method of claim 54, wherein the plurality of resonant structures comprises a longitudinal vibrational mode of a bond.

69. The method of claim 54, wherein the plurality of resonant structures comprises a bending mode of two bonds to an atom.

70. The method of claim 54, wherein the plurality of resonant structures comprises a squashing mode of a plurality of bonds.

71. The method of claim 54, wherein the excitation energies are electromagnetic beams.

82. The method of claim 71, wherein at least one of the electromagnetic beams is an infrared beam.

83. The method of claim 71, wherein at least one of the electromagnetic beams is amplitude modulated.

84. The method of claim 71, wherein at least one of the electromagnetic beams is frequency modulated.

85. The method of claim 71, further comprising scanning at least one of the electromagnetic beams.

87. The method of claim 71, wherein at least two of the electromagnetic beams intersect at a target location.

88. The method of claim 54, further comprising applying a field to the composition, wherein the field acts to preferentially orient at least one resonant structure.

90. The method of claim 54, wherein:

the plurality of resonant structures are in an arrangement having two end resonant structures and a center resonant structure; and

the set of excitation energies is applied in a sequence beginning from the excitation energies having frequencies matching the two end resonant structures and progressing towards the excitation energy having the frequency matching the center resonant structure.

62-67. -67. (canceled)

72-81. -81. (canceled)

86. (canceled)

89. (canceled)

91. An instrument for exciting chemical compositions, comprising:

an interpreter that converts a score comprising a plurality of energy input descriptors into control instructions for an energy input component; and

an energy input component constructed to direct an energy input into a medium in accordance with control instructions generated by the interpreter, wherein the score is selected to specify inputs that induce a group of proximate atoms to shift from a first geometric configuration to a second geometric configuration.

92. The instrument of claim 91, wherein each energy input descriptor comprises a description of at least one attribute selected from the group consisting of frequency, modulation frequency, phase, amplitude, temporal profile, polarization, direction, and coherence.

93. The instrument of claim 91, wherein the energy input component is a laser.

94. The instrument of claim 91, wherein the energy input component comprises a beam control element that directs or modifies the beam.

95. The instrument of claim 94, wherein the beam control element is selected from the group consisting of a reflector, a polarizer, an optical fiber, and a lens.

96. The instrument of claim 91, further comprising a score location component that selects a score to be converted by the interpreter.

97. The instrument of claim 96, wherein the score location component selects the score from a library of scores, each score in the library being associated with one or more compositions, wherein the energy input descriptors of each score describe a set of energy inputs selected to induce a conformational change in its associated one or more compositions.

98. The instrument of claim 97, wherein the library of scores is remote from the energy input component.

99. The instrument of claim 91, wherein the interpreter comprises a controller that receives the score from a source.

100. The instrument of claim 99, further comprising a monitor in communication with the controller, wherein the controller adjusts the score converted by the interpreter in response to an observation by the monitor.

101. The instrument of claim 91, further comprising an input component that allows a user to specify a score to be converted by the interpreter.

102. The instrument of claim 91, further comprising an input component that allows a user to specify a composition or structure;

and

a lookup component that;

determines a score that describes a set of energy inputs selected to induce a conformational change in the specified composition or structure; and

passes the determined score to the interpreter for conversion.

103. The instrument of claim 102, wherein the lookup component accesses a library of scores, each score in the library being associated with one or more compositions.

104. The instrument of claim 103, wherein the library is remote from the energy input component.

105. The instrument of claim 102, wherein the lookup component presents the determined score to the user for approval before passing it to the interpreter.

106. The instrument of claim 105, wherein the lookup component presents the determined score to the user visually.

107. The instrument of claim 105, wherein the lookup component presents the determined score to the user audibly.

108. The instrument of claim 107, wherein the frequencies of the energy inputs described by the determined score are mapped to a set of audible frequencies, and wherein the lookup component presents the determined score to the user by playing the set of audible frequencies.