Means for stimulation and activation of hair growth by il-15
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Abstract
The present invention relates to the use of IL-15 polynucleotides, polypeptides or compounds which bind to an antibody which specifically recognizes the IL-15 polypeptide or which specifically bind to an IL-15 receptor alpha chain for the preparation of a composition for stimulating hair growth or for treating, preventing and/or ameliorating hair loss. Moreover the present invention encompasses a transgenic non-human animal comprising an IL-15 polynucleotide. The present invention also relates to a method for stimulating hair growth in a non-human animal and to methods for manufacturing animal hair. Finally, the present invention relates to a method of treating, preventing and/or ameliorating a subject which suffers from hair loss.
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Citations
74 Claims
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1-23. -23. (canceled)
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24. A method for stimulating hair growth comprising administering to a subject in a therapeutically effective amount of a composition comprising:
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(i) a polynucleotide comprising (a) a nucleic acid sequence as shown in SEQ ID NO;
I or 3,(b) a nucleic acid sequence encoding an amino acid sequence as shown in SEQ ID NO;
2 or 4,(c) a nucleic acid sequence encoding an amino acid sequence as shown in SEQ ID NO;
2 or 4 having a modified signal peptide, a modified N- terminus and/or a modified C-terminus, or(d) a nucleic acid sequence which hybridises under stringent conditions to any one of (a) to (c); (ii) a polypeptide encoded by the nucleic acid as defined in any one of (a) to (c);
or(iii) a compound which binds to an antibody which specifically recognizes the polypeptide defined in (ii) or which specifically binds to an IL- 15 receptor alpha chain. - View Dependent Claims (25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41)
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42. A method for treating, preventing and/or ameliorating hair loss comprising administering to a subject in a therapeutically effective amount of a composition comprising:
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(i) a polynucleotide comprising (a) a nucleic acid sequence as shown in SEQ ID NO;
I or 3,(b) a nucleic acid sequence encoding an amino acid sequence as shown in SEQ ID NO;
2 or 4,(c) a nucleic acid sequence encoding an amino acid sequence as shown in SEQ ID NO;
2 or 4 having a modified signal peptide, a modified N- terminus and/or a modified C-terminus, or(d) a nucleic acid sequence which hybridises under stringent conditions to any one of (a) to (c); (ii) a polypeptide encoded by the nucleic acid as defined in any one of (a) to (c);
or(iii) a compound which binds to an antibody which specifically recognizes the polypeptide defined in (ii) or which specifically binds to an IL-15 receptor alpha chain. - View Dependent Claims (43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59)
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60. A transgenic non-human animal comprising a nucleic acid comprising
(a) a nucleic acid sequence as shown in SEQ ID NO: - I or 3,
(b) a nucleic acid sequence encoding an amino acid sequence as shown in SEQ ID NO;
2 or 4,(c) a nucleic acid sequence encoding an amino acid sequence as shown in SEQ ID NO;
2 or 4 having a modified signal peptide, a modified N- terminus and/or a modified C-terminus, or(d) a nucleic acid sequence which hybridises under stringent conditions to any one of (a) to (c);
wherein said nucleic acid is specifically expressed in the keratinocytes of the hair bulb, in the Langerhans cells, in the melanocytes, in the dendritic epidermal T-cells, in the mast cells, in cutaneous nerve fibres or in fibroblasts. - View Dependent Claims (61)
- I or 3,
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62. A method for stimulating hair growth in a non-human animal comprising:
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(i) transforming said animal with a nucleic acid comprising (a) a nucleic acid sequence as shown in SEQ ID NO;
1 or 3,(b) a nucleic acid sequence encoding an amino acid sequence as shown in SEQIDNO;
2or4,(c) a nucleic acid sequence encoding an amino acid sequence as shown in SEQ ID NO;
2 or 4 having a modified signal peptide, a modified N- terminus and/or a modified C-terminus, or(d) a nucleic acid sequence which hybridises under stringent conditions to any one of (a) to (c); (ii) expressing the polypeptide encoded by said nucleic acid. - View Dependent Claims (63, 64, 65)
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66. A method for manufacturing non-human animal hair comprising:
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(i) transforming said non-human animal with a nucleic acid comprising (a) a nucleic acid sequence as shown in SEQ ID NO;
I or 3,(b) a nucleic acid sequence encoding an amino acid sequence as shown in SEQ ID NO;
2 or 4,(c) a nucleic acid sequence encoding an amino acid sequence as shown in SEQ ID NO;
2 or 4 having a modified signal peptide, a modified N- terminus and/or a modified C-terminus, or(d) a nucleic acid sequence which hybridises under stringent conditions to any one of (a) to (c); and (ii) expressing the polypeptide encoded by said nucleic acid. - View Dependent Claims (67, 68, 69, 70, 71)
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72. A method for manufacturing non-human animal hair comprising administering to the skin and/or scalp of a non-human animal the composition
(i) a polynucleotide comprising (a) a nucleic acid sequence as shown in SEQ ID NO: - I or 3,
(b) a nucleic acid sequence encoding an amino acid sequence as shown in SEQ ID NO;
2 or 4,(c) a nucleic acid sequence encoding an amino acid sequence as shown in SEQ ID NO;
2 or 4 having a modified signal peptide, a modified N- terminus and/or a modified C-terminus, or(d) a nucleic acid sequence which hybridises under stringent conditions to any one of (a) to (c); (ii) a polypeptide encoded by the nucleic acid as defined in any one of (a) to (c);
or(iii) a compound which binds to an antibody which specifically recognizes the polypeptide defined in (ii) or which specifically binds to an IL-15 receptor alpha chain. - View Dependent Claims (73, 74)
- I or 3,
Specification