RAPAMYCIN AND IL-10 FOR THE TREATMENT OF IMMUNE DISEASES
First Claim
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1. A method for inducing antigen-specific immune tolerance in a subject affected by a disease involving an excessive, dysfunctional or uncontrolled self- or non-self T cell mediated immune response, comprising administering to said subject an effective amount IL-10 and rapamycin, or an analog, derivative or conjugate thereof.
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Abstract
The invention discloses a combined preparation containing IL-10 and rapamycin, able to induce immunosuppression and antigen-specific immune tolerance, and the use thereof in the treatment of diseases involving an excessive, dysfunctional or uncontrolled immune responses mediated by T cells.
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11 Claims
- 1. A method for inducing antigen-specific immune tolerance in a subject affected by a disease involving an excessive, dysfunctional or uncontrolled self- or non-self T cell mediated immune response, comprising administering to said subject an effective amount IL-10 and rapamycin, or an analog, derivative or conjugate thereof.
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