Compositions And Methods For Inhibiting Adhesions
First Claim
1. A method of inhibiting adhesions, the method comprising the steps of:
- administering a first hydrogel precursor to a location within the body of a subject; and
administering a second hydrogel precursor to the location within the body of the subject, wherein the first hydrogel precursor is a cellulose derivative or a dextran derivative;
wherein the second hydrogel precursor is a dextran derivative;
wherein the first and second hydrogel precursors become crosslinked to form a hydrogel following contact of the hydrogel precursors with one another; and
wherein the hydrogel inhibits adhesions.
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Accused Products
Abstract
The present invention provides compositions and methods for inhibiting adhesions. The methods involve administering solutions containing hydrogel precursors such as polysaccharide derivatives, e.g., derivatives of hyaluronic acid, cellulose, or dextran, to a subject at a site where adhesions may form, e.g., as a consequence of surgery, injury, or infection. The hydrogel precursors, e.g., polysaccharide derivatives, become crosslinked following their administration to form a hydrogel that maintains tissue separation. In certain embodiments of the invention one or both solutions contains particles, e.g., polymeric nanoparticles or microparticles, so that a composite hydrogel containing the particles is formed. The solution(s), particle(s), or both, may contain a biologically active agent such as an agent that contributes to inhibiting adhesions. The biologically active agent may be covalently attached to a hydrogel precursor.
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Citations
60 Claims
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1. A method of inhibiting adhesions, the method comprising the steps of:
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administering a first hydrogel precursor to a location within the body of a subject; and
administering a second hydrogel precursor to the location within the body of the subject, wherein the first hydrogel precursor is a cellulose derivative or a dextran derivative;
wherein the second hydrogel precursor is a dextran derivative;
wherein the first and second hydrogel precursors become crosslinked to form a hydrogel following contact of the hydrogel precursors with one another; and
wherein the hydrogel inhibits adhesions. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41)
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42. A composition comprising:
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(a) a cellulose derivative;
(b) a dextran derivative; and
(c) a plurality of particles. - View Dependent Claims (43, 44, 45, 46, 47, 48, 49, 50)
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51. A method of administering particles to a location within the body comprising:
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administering a composition comprising particles, a first hydrogel precursor, and a second hydrogel precursor, to the location, wherein the first hydrogel precursor is a cellulose derivative or a dextran derivative;
wherein the second hydrogel precursor is a dextran derivative; and
wherein the first and second hydrogel precursors form a hydrogel that entraps the particles therein following administration. - View Dependent Claims (52, 53, 54)
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55. A method of administering a biologically active agent to a subject comprising steps of:
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administering a composition comprising a biologically active agent, a first hydrogel precursor, and a second hydrogel precursor to the location, wherein the first hydrogel precursor is a cellulose derivative or a dextran derivative;
wherein the second hydrogel precursor is a dextran derivative; and
wherein the first and second hydrogel precursors form a hydrogel that entraps the biologically active agent therein. - View Dependent Claims (56, 57, 58, 59, 60)
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Specification