Formulations and methods for modulating satiety
First Claim
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1. A pharmaceutical formulation for oral administration to a patient effective to reduce feeding in a patient, comprising:
- an appetite-suppressing peptide; and
at least one chelating agent;
wherein at least one of the appetite-suppressing peptide and the at least one chelating agent is encased in an enteric protectant; and
wherein the combination of the chelating agent and enteric protectant is effective to increase the bioavailability of the appetite-suppressing peptide.
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Abstract
Formulations and methods of suppressing appetite and eliciting satiety in mammals are described. In some embodiments, oral administration of an effective amount of an appetite-suppressing peptide, in a composition that increases the bioavailability of the appetite-suppressing peptide, are effective to produce a feeling of satiety.
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Citations
47 Claims
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1. A pharmaceutical formulation for oral administration to a patient effective to reduce feeding in a patient, comprising:
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an appetite-suppressing peptide; and
at least one chelating agent;
wherein at least one of the appetite-suppressing peptide and the at least one chelating agent is encased in an enteric protectant; and
wherein the combination of the chelating agent and enteric protectant is effective to increase the bioavailability of the appetite-suppressing peptide. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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26. A method of reducing feeding in a patient comprising:
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providing a pharmaceutical formulation, comprising;
an appetite-suppressing peptide and at least one chelating agent;
wherein the pharmaceutical formulation is encased in an enteric protectant, and wherein the combination of the chelating agent and enteric protecting is effective to increase the bioavailability of the appetite-suppressing peptide; and
administering the pharmaceutical formulation to the patient. - View Dependent Claims (27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47)
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Specification