Drug Delivery Systems Comprising Solid Solutions of Weakly Basic Drugs
First Claim
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1. A pharmaceutical composition comprising TPR beads, wherein said TPR beads comprise:
- a solid dispersion of at least one active pharmaceutical ingredient in at least one solubility-enhancing polymer; and
a TPR coating comprising a water insoluble polymer and an enteric polymer;
wherein the active pharmaceutical ingredient comprises a weakly basic active pharmaceutical ingredient having a solubility of not more than 100 μ
g/mL at pH 6.8.
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Abstract
The present invention is directed to pharmaceutical compositions and dosage forms comprising TPR beads, wherein said TPR beads comprise a solid dispersion of at least one active pharmaceutical ingredient in at least one solubility-enhancing polymer, and a TPR coating comprising a water insoluble polymer and an enteric polymer, wherein the active pharmaceutical ingredient comprises a weakly basic active pharmaceutical ingredient having a solubility of not more than 100 μg/mL at pH 6.8.
82 Citations
25 Claims
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1. A pharmaceutical composition comprising TPR beads, wherein said TPR beads comprise:
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a solid dispersion of at least one active pharmaceutical ingredient in at least one solubility-enhancing polymer; and
a TPR coating comprising a water insoluble polymer and an enteric polymer;
wherein the active pharmaceutical ingredient comprises a weakly basic active pharmaceutical ingredient having a solubility of not more than 100 μ
g/mL at pH 6.8. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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Specification