Compressible resilient granules and formulations prepared therefrom
First Claim
1. A resilient self-adhering granule which comprises a polysaccharide present in an amount from about 10 wt % to about 90 wt % and a binder having a viscosity from about 5,000 mPa·
- s to about 250,000 mPa·
s present in an amount from about 90 wt % to about 10 wt %, wherein the granule is capable of reversible agglomeration at or below 6,500 kilonewtons/m2.
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Accused Products
Abstract
The present invention provides resilient self-adhering granules which comprise a polysaccharide present in an amount from about 10 wt % to about 90 wt % and a binder having a viscosity from about 5,000 mPa·s to about 250,000 mPa·s present in an amount from about 90 wt % to about 10 wt %, wherein the granule is capable of reversible agglomeration at or below 6,500 kilonewtons/m2. The present invention also provides oral dosage compositions comprising the resilient self-adhering granules and methods for making and using the resilient self-adhering granules.
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Citations
55 Claims
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1. A resilient self-adhering granule which comprises a polysaccharide present in an amount from about 10 wt % to about 90 wt % and a binder having a viscosity from about 5,000 mPa·
- s to about 250,000 mPa·
s present in an amount from about 90 wt % to about 10 wt %, wherein the granule is capable of reversible agglomeration at or below 6,500 kilonewtons/m2. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
- s to about 250,000 mPa·
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17. An oral dosage composition comprising resilient self-adhering granules which comprise a polysaccharide present in an amount from about 10 wt % to about 90 wt % and a binder having a viscosity from about 5,000 mPa·
- s to about 250,000 mPa·
s present in an amount from about 90 wt % to about 10 wt %, wherein the granule is capable of reversible agglomeration at or below 6,500 kilonewtons/m2 and the granules have agglomerated to form the oral dosage composition. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34)
- s to about 250,000 mPa·
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35. A method for making a resilient self-adhering granule which comprises a polysaccharide present in an amount from about 10 wt % to about 90 wt % and a binder having a viscosity from about 5,000 mPa·
- s to about 250,000 mPa·
s present in an amount from about 90 wt % to about 10 wt %, wherein the granule is capable of reversible agglomeration at or below 6,500 kilonewtons/m2, which comprises the steps of;
(a) mixing and heating the polysaccharide and binder in a mixer to form a reaction mixture; and
(b) extruding the reaction mixture from step (a), cooling the reaction mixture to room temperature, milling the reaction mixture to a particular granule size, and cooling the reaction mixture in a freezer. - View Dependent Claims (36, 37, 38, 39, 40)
- s to about 250,000 mPa·
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41. A method for administering an oral dosage composition to a subject comprising:
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a) providing resilient self-adhering granules which comprises a polysaccharide present in an amount from about 10 wt % to about 90 wt % and a binder having a viscosity from about 5,000 mPa·
s to about 250,000 mPa·
s present in an amount from about 90 wt % to about 10 wt %, wherein the granule is capable of reversible agglomeration at or below 6,500 kilonewtons/m2; and
b) administering the oral dosage composition to a subject'"'"'s oral cavity, wherein the majority of the resilient self-adhering granules is released in the gastrointestinal tract. - View Dependent Claims (42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55)
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Specification