Medical Components Having Coated Surfaces Exhibiting Low Friction and Methods of Reducing Sticktion

• US 20080069970A1
• Filed: 09/14/2007
• Published: 03/20/2008
• Est. Priority Date: 09/15/2006
• Status: Abandoned Application

• Current Assignee: Becton, Dickinson & Co
• Original Assignee: Becton, Dickinson & Co
• Inventors: Wu, Shang-Ren
• Application Number:
  US11/855,243
• Publication Number:
  US 20080069970A1
• Time in Patent Office: Days
• US Class Current: 427/553
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61M 5/3129 Syringe barrels A61M5/3205 and A61M5/50 take precedence
• CPC Class Codes: C08L 83/04 Polysiloxanes

Abstract

A medical article is provided including a chamber formed from a cyclic polyolefin having an inner surface in sliding engagement with an exterior surface of a sealing member, the inner surface of the chamber being coated with a first organopolysiloxane having a viscosity ranging from about 5,000 centistokes to about 100,000 centistokes; and a sealing member having an exterior surface coated with a second organopolysiloxane having a viscosity ranging from about 10,000 centistokes to about 500,000 centistokes, the coatings being adhered to the surfaces by crosslinking induced by irradiation with an isotope, electron beam, or ultraviolet radiation, as well as methods of reducing breakloose force, sustaining force, and/or sticktion between engaging surfaces in such articles.

Claims

1. A medical article comprising:

(a) a chamber formed from a cyclic polyolefin and having an inner surface in sliding engagement with an exterior surface of a sealing member, wherein the inner surface of the chamber has a coating thereon prepared from a composition comprising a first organopolysiloxane having a viscosity ranging from about 5,000 centistokes to about 100,000 centistokes, the coating being adhered to the inner surface by crosslinking induced by irradiation with an isotope, electron beam, or ultraviolet radiation; and

(b) a sealing member having an exterior surface in sliding engagement with the interior surface of the chamber, the exterior surface of the sealing member having a coating thereon prepared from a composition comprising a second organopolysiloxane having a viscosity ranging from about 10,000 centistokes to about 500,000 centistokes, the coating being adhered to the exterior surface by crosslinking induced by irradiation with an isotope, electron beam, or ultraviolet radiation.

2. The medical article according to claim 1, wherein the medical article is selected from the group consisting of syringe assemblies, drug cartridges, needleless injectors, liquid dispensing devices, and liquid metering devices.

3. The medical article according to claim 1, wherein the chamber is a syringe barrel.

4. The medical article according to claim 1, wherein at least one of the first organopolysiloxane or the second organopolysiloxane is represented by the following structural Formula (I):

5. The medical article according to claim 1, wherein at least one of the first organopolysiloxane or the second organopolysiloxane is polydimethylsiloxane.

6. The medical article according to claim 1, wherein at least one of the first organopolysiloxane or the second organopolysiloxane comprises at least one alkenyl group.

7. The medical article according to claim 6, wherein each alkenyl group of the organopolysiloxane is independently selected from the group consisting of vinyl, allyl, propenyl, butenyl, pentenyl, hexenyl, heptenyl, octenyl, nonenyl, and decenyl.

8. The medical article according to claim 7, wherein at least one alkenyl group of the organopolysiloxane is vinyl.

9. The medical article according to claim 1, wherein at least one of the first organopolysiloxane or the second organopolysiloxane comprises at least two polar groups.

10. The medical article according to claim 9, wherein each polar group of the organopolysiloxane is independently selected from the group consisting of acrylate, methacrylate, amino, imino, hydroxy, epoxy, ester, alkyloxy, isocyanate, phenolic, polyurethane oligomeric, polyamide oligomeric, polyester oligomeric, polyether oligomeric, polyol, carboxypropyl, and fluoro groups.

11. The medical article according to claim 1, wherein the first organopolysiloxane has a viscosity of about 12,500 centistokes.

12. The medical article according to claim 1, wherein the second organopolysiloxane has a viscosity of about 12,500 to about 300,000 centistokes.

13. The medical article according to claim 12, wherein the second organopolysiloxane has a viscosity of about 12,500 centistokes.

14. The medical article according to claim 12, wherein the second organopolysiloxane has a viscosity of about 100,000 centistokes.

15. The medical article according to claim 12, wherein the second organopolysiloxane has a viscosity of about 300,000 centistokes.

16. The medical article according to claim 1, wherein the sealing member is selected from the group consisting of a stopper, O-ring, plunger tip, and piston.

17. The medical article according to claim 1, wherein the sealing member is formed from rubber.

18. The medical article according to claim 17, wherein the sealing member is formed from butyl rubber.

19. The medical article according to claim 1, wherein the sealing member is formed from thermoplastic elastomer or thermoplastic vulcanizate.

20. The medical article according to claim 19, wherein the sealing member is formed from styrene-butadiene copolymer.

21. A method for lubricating the interface between an inner surface of a chamber formed from a cyclic polyolefin and an exterior surface of a sealing member of a medical article, comprising the steps of:

(a) applying a coating onto an inner surface of the chamber, the coating being prepared from a composition comprising a first organopolysiloxane having a viscosity ranging from about 5,000 centistokes to about 100,000 centistokes;

(b) applying a coating onto an exterior surface of the sealing member, the coating being prepared from a composition comprising a second organopolysiloxane having a viscosity ranging from about 10,000 centistokes to about 500,000 centistokes; and

(c) irradiating the coating of the inner surface of the chamber and the coating of the exterior surface of the sealing member with an isotope, electron beam, or ultraviolet radiation.

22. The method according to claim 21, wherein the coating of the inner surface of the chamber and the coating of the exterior surface of the sealing member are irradiated consecutively.

23. A method for reducing breakloose force between an inner surface of a chamber formed from a cyclic polyolefin and an exterior surface of a sealing member of a medical article, comprising the steps of:

(a) applying a coating onto an inner surface of the chamber, the coating being prepared from a composition comprising a first organopolysiloxane having a viscosity ranging from about 5,000 centistokes to about 100,000 centistokes;

(b) applying a coating onto an exterior surface of the sealing member, the coating being prepared from a composition comprising a second organopolysiloxane having a viscosity ranging from about 10,000 centistokes to about 500,000 centistokes; and

(c) irradiating the coating of the inner surface of the chamber and the coating of the exterior surface of the sealing member with an isotope, electron beam, or ultraviolet radiation.

24. A method for reducing sustaining force between an inner surface of a chamber formed from a cyclic polyolefin and an exterior surface of a sealing member of a medical article, comprising the steps of:

(a) applying a coating onto an inner surface of the chamber, the coating being prepared from a composition comprising a first organopolysiloxane having a viscosity ranging from about 5,000 centistokes to about 100,000 centistokes;

(b) applying a coating onto an exterior surface of the sealing member, the coating being prepared from a composition comprising a second organopolysiloxane having a viscosity ranging from about 10,000 centistokes to about 500,000 centistokes; and

(c) irradiating the coating of the inner surface of the chamber and the coating of the exterior surface of the sealing member with an isotope, electron beam, or ultraviolet radiation.

25. A method for reducing sticktion between an inner surface of a chamber formed from a cyclic polyolefin and an exterior surface of a sealing member of a medical article, comprising the steps of:

(a) applying a coating onto an inner surface of the chamber, the coating being prepared from a composition comprising a first organopolysiloxane having a viscosity ranging from about 5,000 centistokes to about 100,000 centistokes;

(b) applying a coating onto an exterior surface of the sealing member, the coating being prepared from a composition comprising a second organopolysiloxane having a viscosity ranging from about 10,000 centistokes to about 500,000 centistokes; and

(c) irradiating the coating of the inner surface of the chamber and the coating of the exterior surface of the sealing member with an isotope, electron beam, or ultraviolet radiation.