COATINGS FOR DRUG DELIVERY DEVICES BASED ON POLY (ORTHOESTERS)
First Claim
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1. A coating for a medical device comprising:
- a block copolymer and an additional polymer, wherein the block copolymer has a first block comprising a soft segment having a Tg below 37°
C. wherein the soft segment is a reaction product of a spirodiketene acetal and a non-fouling moiety selected from the group consisting of a poly(alkylene glycol), poly(ethylene oxide-co-propylene oxide) (PLURONIC®
), hydroxylated poly(vinyl pyrrolidone), dextran, dextrin, hyaluronic acid and derivatives thereof, poly(2-hydroxyethyl methacrylate) and mixtures thereof; and
, a second block comprising a hard segment having a Tg above 37°
C. wherein the hard segment is a reaction product of a spirodiketene acetal and a C2-C16 alkylene glycol, a cycloaliphatic diol, a cyclohexanedimethanol, and an oligoaliphatic diol selected from the group consisting of diethylene glycol, triethylene glycol or tetraethylene glycol.
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Abstract
A polymer coating for implantable medical devices based on polyorthoesters and methods for fabricating the coating are disclosed. The implantable medical devices made of polyorthoesters and methods for fabricating thereof are also disclosed.
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Citations
22 Claims
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1. A coating for a medical device comprising:
- a block copolymer and an additional polymer, wherein the block copolymer has a first block comprising a soft segment having a Tg below 37°
C. wherein the soft segment is a reaction product of a spirodiketene acetal and a non-fouling moiety selected from the group consisting of a poly(alkylene glycol), poly(ethylene oxide-co-propylene oxide) (PLURONIC®
), hydroxylated poly(vinyl pyrrolidone), dextran, dextrin, hyaluronic acid and derivatives thereof, poly(2-hydroxyethyl methacrylate) and mixtures thereof; and
,a second block comprising a hard segment having a Tg above 37°
C. wherein the hard segment is a reaction product of a spirodiketene acetal and a C2-C16 alkylene glycol, a cycloaliphatic diol, a cyclohexanedimethanol, and an oligoaliphatic diol selected from the group consisting of diethylene glycol, triethylene glycol or tetraethylene glycol. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
- a block copolymer and an additional polymer, wherein the block copolymer has a first block comprising a soft segment having a Tg below 37°
Specification