Medical Components Having Coated Surfaces Exhibiting Low Friction and Methods of Reducing Sticktion

• US 20080071228A1
• Filed: 09/14/2007
• Published: 03/20/2008
• Est. Priority Date: 09/15/2006
• Status: Abandoned Application

• Current Assignee: Becton, Dickinson & Co
• Original Assignee: Becton, Dickinson & Co
• Inventors: Alvarez, Angel, Simmons, Stephen, Wu, Shang-Ren
• Application Number:
  US11/855,437
• Publication Number:
  US 20080071228A1
• Time in Patent Office: Days
• US Class Current: 604/234
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/14 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61M 2005/3131 specially adapted for improving sealing or sliding
• CPC Class Codes: A61M 2207/00 Methods of manufacture, assembly or production
• CPC Class Codes: A61M 5/31513 Piston constructions to improve sealing or sliding

Abstract

This invention relates to components useful for medical articles, such as a syringe assembly, having sliding surface(s) coated with a composition including organopolysiloxane(s), the coating being adhered to the surface(s) of the component by crosslinking induced by oxidative treatment and irradiation with an isotope, electron beam or ultraviolet radiation or heat treatment; medical articles including the same; methods to reduce static and kinetic friction between slidable surfaces; and articles of low friction prepared thereby.

Claims

1. A chamber for a medical article, the chamber having an inner surface adapted to sealingly engage an outer surface of a sealing member for a medical article, wherein the inner surface of the chamber has a coating thereon prepared from a composition comprising an organopolysiloxane, the coating being adhered to the inner surface by crosslinking induced by (1) oxidative treatment;

and (2) (a) irradiation with an isotope, electron beam or ultraviolet radiation or (b) heat treatment.

2. The chamber according to claim 1, wherein the chamber is selected from the group consisting of a syringe barrel, drug cartridge container, needleless injector container, liquid dispensing device container, and liquid metering device container.

3. The chamber according to claim 2, wherein the chamber is a syringe barrel.

4. The chamber according to claim 1, wherein the chamber is formed from glass, metal, ceramic, plastic, rubber, or combinations thereof.

5. The chamber according to claim 4, wherein the chamber is prepared from an olefinic polymer selected from the group consisting of polyethylene, polypropylene, poly(1-butene), poly(2-methyl-1-pentene), and cyclic polyolefins.

6. The chamber according to claim 1, wherein the organopolysiloxane is represented by the following structural Formula (I):

7. The chamber according to claim 1, wherein the organopolysiloxane is polydimethylsiloxane.

8. The chamber according to claim 1, wherein the organopolysiloxane comprises at least two alkenyl groups, each alkenyl group being independently selected from the group consisting of vinyl, allyl, propenyl, butenyl, pentenyl, hexenyl, heptenyl, octenyl, nonenyl, and decenyl.

9. The chamber according to claim 1, wherein the organopolysiloxane comprises at least two polar groups, each polar group being independently selected from the group consisting of acrylate, methacrylate, amino, imino, hydroxy, epoxy, ester, alkyloxy, isocyanate, phenolic, polyurethane oligomeric, polyamide oligomeric, polyester oligomeric, polyether oligomeric, polyol, carboxypropyl, and fluoro groups.

10. The chamber according to claim 1, wherein the organopolysiloxane has a viscosity of about 100 to about 1,000,000 centistokes.

11. The chamber according to claim 10, wherein the organopolysiloxane has a viscosity of about 12,500 centistokes.

12. The chamber according to claim 1, wherein the coated and oxidatively treated chamber is irradiated with gamma radiation, electron beam radiation, or ultraviolet light.

13. The chamber according to claim 12, wherein the coated and oxidatively treated chamber is irradiated with gamma radiation of about 5 to about 50 kiloGreys.

23. A medical article comprising:

(a) the chamber according to claim 1;

and

(b) a sealing member having an exterior surface in sliding engagement with the interior surface of the chamber.

14. A sealing member for a medical article, the sealing member having an exterior surface in sliding engagement with an interior surface of a chamber of a medical article and adapted to sealingly engage the interior surface of the chamber, wherein the exterior surface of the sealing member has a coating thereon prepared from a composition comprising an organopolysiloxane, the coating being adhered to the exterior surface by crosslinking induced by (1) oxidative treatment;

and (2) (a) irradiation with an isotope, electron beam or ultraviolet radiation or (b) heat treatment.

15. The sealing member according to claim 14, wherein the sealing member is selected from the group consisting of a stopper, O-ring, plunger tip, and piston.

16. The sealing member according to claim 14, wherein the sealing member is formed from rubber.

17. The sealing member according to claim 14, wherein the organopolysiloxane is polydimethylsiloxane.

18. The sealing member according to claim 14, wherein the organopolysiloxane comprises at least two alkenyl groups, each alkenyl group being independently selected from the group consisting of vinyl, allyl, propenyl, butenyl, pentenyl, hexenyl, heptenyl, octenyl, nonenyl, and decenyl.

19. The sealing member according to claim 14, wherein the organopolysiloxane comprises at least two polar groups, each polar group being independently selected from the group consisting of acrylate, methacrylate, amino, imino, hydroxy, epoxy, ester, alkyloxy, isocyanate, phenolic, polyurethane oligomeric, polyamide oligomeric, polyester oligomeric, polyether oligomeric, polyol, carboxypropyl, and fluoro groups.

20. The sealing member according to claim 14, wherein the organopolysiloxane has a viscosity of about 100 to about 1,000,000 centistokes.

21. The sealing member according to claim 14, wherein the coated sealing member is subjected to an oxidative treatment selected from the group consisting of atmospheric ionizing plasma treatment and vacuum ionizing plasma treatment.

22. The sealing member according to claim 14, wherein the coated and oxidatively treated sealing member is irradiated with gamma radiation, electron beam radiation, or ultraviolet light.

24. A medical article comprising:

(a) a chamber having an inner surface adapted to sealingly engage an outer surface of a sealing member; and

(b) the sealing member according to claim 14.

25. A method for lubricating the interface between an inner surface of a chamber and an exterior surface of a sealing member of a medical article, comprising the steps of:

(a) applying a coating onto the interior surface of the chamber and/or the exterior surface of the sealing member, the coating being prepared from a composition comprising an organopolysiloxane;

(b) treating the coating with oxidative treatment; and

(c) (1) irradiating the coating with an isotope, electron beam, or ultraviolet radiation or (2) heat treatment.