Axial-force fixation member for valve
First Claim
1. Apparatus comprising a prosthesis for implantation at a native semilunar valve of a native valve complex of a subject, the prosthesis comprising:
- a distal fixation member, configured to be positioned in a downstream artery of the subject selected from the group consisting of;
an ascending aorta, and a pulmonary trunk, and to apply a first axial force directed toward a ventricle of the subject; and
a proximal fixation member coupled to the distal fixation member, the proximal fixation member configured to be positioned at least partially on a ventricular side of the native valve complex, and to apply a second axial force directed toward the downstream artery, such that application of the first and second forces couples the prosthesis to the native valve complex by axially sandwiching the native valve complex from a downstream side and the ventricular side thereof,wherein the prosthesis is configured to apply the first axial force such that a ratio of (a) the first axial force to (b) a radial force applied outwardly by the prosthesis against the native semilunar valve is greater than 1.5;
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Accused Products
Abstract
A prosthesis is provided for implantation at a native semilunar valve of a native valve complex. The prosthesis includes a distal fixation member, configured to be positioned in a downstream artery, and to apply a first axial force directed toward a ventricle. The prosthesis further includes a proximal fixation member coupled to the distal fixation member, the proximal fixation member configured to be positioned at least partially on a ventricular side of the native valve complex, and to apply a second axial force directed toward the downstream artery, such that application of the first and second forces couples the prosthesis to the native valve complex by axially sandwiching the native valve complex from a downstream side and the ventricular side. A ratio of the first axial force to a radial force applied outwardly by the prosthesis against the native semilunar valve is greater than 1.5:1. Other embodiments are also described.
735 Citations
59 Claims
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1. Apparatus comprising a prosthesis for implantation at a native semilunar valve of a native valve complex of a subject, the prosthesis comprising:
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a distal fixation member, configured to be positioned in a downstream artery of the subject selected from the group consisting of;
an ascending aorta, and a pulmonary trunk, and to apply a first axial force directed toward a ventricle of the subject; anda proximal fixation member coupled to the distal fixation member, the proximal fixation member configured to be positioned at least partially on a ventricular side of the native valve complex, and to apply a second axial force directed toward the downstream artery, such that application of the first and second forces couples the prosthesis to the native valve complex by axially sandwiching the native valve complex from a downstream side and the ventricular side thereof, wherein the prosthesis is configured to apply the first axial force such that a ratio of (a) the first axial force to (b) a radial force applied outwardly by the prosthesis against the native semilunar valve is greater than 1.5;
1. - View Dependent Claims (4, 5, 6, 7, 8, 9, 12, 13, 19, 20, 21, 26, 27, 29)
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2-3. -3. (canceled)
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10-11. -11. (canceled)
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14-18. -18. (canceled)
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22-25. -25. (canceled)
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28. (canceled)
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30-34. -34. (canceled)
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35. Apparatus comprising a prosthesis for implantation at a native semilunar valve of a native valve complex of a subject, the prosthesis comprising:
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a distal fixation member, configured to be positioned in a downstream artery of the subject selected from the group consisting of;
an ascending aorta, and a pulmonary trunk, and to apply a first axial force directed toward a ventricle of the subject; anda proximal fixation member coupled to the distal fixation member, the proximal fixation member configured to be positioned at least partially on a ventricular side of the native valve complex, and to apply a second axial force directed toward the downstream artery, such that application of the first and second forces couples the prosthesis to the native valve complex by axially sandwiching the native valve complex from a downstream side and the ventricular side thereof, wherein the prosthesis is configured such that any radial force applied by the prosthesis outwardly against the native semilunar valve is insufficient by itself to chronically maintain the prosthesis in position with respect to the native valve complex under conditions of normal cardiac motion. - View Dependent Claims (40, 41, 42)
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36-39. -39. (canceled)
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43-51. -51. (canceled)
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52. A method for implanting a valve prosthesis at a native semilunar valve of a native valve complex of a subject, the method comprising:
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providing a distal fixation member of the valve prosthesis coupled to a proximal fixation member of the valve prosthesis; positioning the distal fixation member in a downstream artery of the subject selected from the group consisting of;
an ascending aorta, and a pulmonary trunk, such that the distal fixation member applies a first axial force directed toward a ventricle of the subject, such that a ratio of (a) the first axial force to (b) a radial force applied outwardly by the prosthesis against the native semilunar valve is greater than 1.5;
1; andpositioning the proximal fixation member at least partially on a ventricular side of the native valve complex, such that the proximal fixation member applies a second axial force directed toward the downstream artery, and application of the first and second forces couples the prosthesis to the native valve complex by axially sandwiching the native valve complex from a downstream side and the ventricular side thereof. - View Dependent Claims (53)
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54-57. -57. (canceled)
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58. A method for implanting a valve prosthesis at a native semilunar valve of a native valve complex of a subject, the method comprising:
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providing a distal fixation member of the valve prosthesis coupled to a proximal fixation member of the valve prosthesis; positioning the distal fixation member in a downstream artery of the subject selected from the group consisting of;
an ascending aorta, and a pulmonary trunk, such that the distal fixation member applies a first axial force directed toward a ventricle of the subject; andpositioning the proximal fixation member at least partially on a ventricular side of the native valve complex, such that the proximal fixation member applies a second axial force directed toward the downstream artery, and application of the first and second forces couples the prosthesis to the native valve complex by axially sandwiching the native valve complex from a downstream side and the ventricular side thereof, wherein positioning the distal and proximal fixation members comprises positioning the distal and proximal fixation members such that any radial force applied by the prosthesis outwardly against the native semilunar valve is insufficient by itself to chronically maintain the prosthesis in position with respect to the native valve complex under conditions of normal cardiac motion.
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59-63. -63. (canceled)
Specification