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MVA vaccine

  • US 20080075694A1
  • Filed: 07/19/2007
  • Published: 03/27/2008
  • Est. Priority Date: 01/24/2005
  • Status: Abandoned Application
First Claim
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1. A kit of parts comprising the following components:

  • a) a first component comprising one or more foreign proteins or a nucleic acid encoding same or functional parts thereof, which functional parts contain one or more substitutions, insertions and/or deletions when compared to the wild type protein whilst having the same function as the wild type protein; and

    b) a second component comprising a recombinant Modified Vaccinia Virus Ankara (MVA), which carries a nucleic acid sequence coding for a fusion protein comprising;

    Ubiquitin or a functional part thereof, which functional part contains one or more substitutions, insertions and/or deletions when compared to the wild type protein whilst having the same function as the wild type protein; and

    one or more foreign proteins, i.e. one or more proteins not naturally present as a part of MVA or functional parts thereof, which functional part contains one or more substitutions, insertions and/or deletions when compared to the wild type protein whilst having the same function as the wild type protein;

    wherein the first and second components optionally further comprise a pharmaceutically acceptable carrier.

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