Antigen Imitating Extracellular Areas of Membrane Proteins of Type III Produced from Intracellular Pathogenic Micro-Organisms, Derived Conformational Antibodies and the Use Thereof
First Claim
1. A chimeric antigen derived from an intracellular pathogenic microorganism, comprising at least one peptide fragment consisting essentially of the concatenation of the sequences of at least two adjacent extracellular domains in the native structure of a type III membrane protein of said intracellular pathogenic microorganism, and wherein the antigen induces the production, in individuals immunized with said antigen, of conformational antibodies that recognize said type type III membrane protein in the native form.
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Abstract
The inventive antigen derived from an intracellular pathogenic micro-organism is characterised in that it comprises at least on peptidic fragment which essentially consists of the concatenation of sequences of at least two extracellular adjacent areas in the native structure of a membrane protein of type III of said intracellular pathogenic micro-organism, derived conformational antibodies and the application thereof.
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Citations
34 Claims
- 1. A chimeric antigen derived from an intracellular pathogenic microorganism, comprising at least one peptide fragment consisting essentially of the concatenation of the sequences of at least two adjacent extracellular domains in the native structure of a type III membrane protein of said intracellular pathogenic microorganism, and wherein the antigen induces the production, in individuals immunized with said antigen, of conformational antibodies that recognize said type type III membrane protein in the native form.
- 31. An isolated nucleic acid molecule, comprising a sequence encoding an antigen as claimed.
Specification