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Anti-IL-6 monoclonal antibodies and uses thereof

  • US 20080075726A1
  • Filed: 08/03/2007
  • Published: 03/27/2008
  • Est. Priority Date: 08/03/2006
  • Status: Active Grant
First Claim
Patent Images

1. An isolated monoclonal antibody comprising:

  • (a) a variable heavy chain region (VH) comprising;

    (i) a VH-CDR1 comprising an amino acid sequence selected from the group consisting of;

    SEQ ID NO;

    51, SEQ ID NO;

    52, SEQ ID NO;

    53, SEQ ID NO;

    54, SEQ ID NO;

    55, and an amino acid sequence that is identical to any one of SEQ ID NOs;

    51-55 except for 1 to 5 amino acid substitutions;

    (ii) a VH-CDR2 comprising an amino acid sequence selected from the group consisting of;

    SEQ ID NO;

    56, SEQ ID NO;

    57, SEQ ID NO;

    58, SEQ ID NO;

    59, SEQ ID NO;

    60, SEQ ID NO;

    61, SEQ ID NO;

    97, and an amino acid sequence that is identical to any one of SEQ ID NOs;

    56 to 61 or 97 except for 1 to 5 amino acid substitutions;

    (iii) a VH-CDR3 comprising an amino acid sequence selected from the group consisting of;

    SEQ ID NO;

    62, SEQ ID NO;

    63, SEQ ID NO;

    64, SEQ ID NO;

    65, SEQ ID NO;

    66, SEQ ID NO;

    67, SEQ ID NO;

    68, SEQ ID NO;

    69, SEQ ID NO;

    70, SEQ ID NO;

    71, SEQ ID NO;

    72, SEQ ID NO;

    73, SEQ ID NO;

    98, and an amino acid sequence that is identical to any one of SEQ ID NOs;

    62 to 73 or 98 except for 1 to 5 amino acid substitutions; and

    (b) a variable light chain region (VL) comprising;

    (i) a VL-CDR1 comprising an amino acid sequence selected from the group consisting of;

    SEQ ID NO;

    74, SEQ ID NO;

    75, SEQ ID NO;

    76, SEQ ID NO;

    77, SEQ ID NO;

    78, SEQ ID NO;

    79, and an amino acid sequence that is identical to any one of SEQ ID NOs;

    74-79 except for 1 to 5 amino acid substitutions;

    (ii) a VL-CDR2 comprising an amino acid sequence selected from the group consisting of;

    SEQ ID NO;

    80, SEQ ID NO;

    81, SEQ ID NO;

    82, SEQ ID NO;

    83, SEQ ID NO;

    84, SEQ ID NO;

    85, and an amino acid sequence that is identical to any one of SEQ ID NOs;

    80-85 except for 1 to 5 amino acid substitutions;

    (iii) a VL-CDR3 comprising an amino acid sequence selected from the group consisting of;

    SEQ ID NO;

    86, SEQ ID NO;

    87, SEQ ID NO;

    88, SEQ ID NO;

    89, SEQ ID NO;

    90, SEQ ID NO;

    91, SEQ ID NO;

    92, SEQ ID NO;

    93, SEQ ID NO;

    94, SEQ ID NO;

    95, SEQ ID NO;

    96, and an amino acid sequence that is identical to any one of SEQ ID NOs;

    86-96 except for 1 to 5 amino acid substitutions;

    wherein said antibody binds specifically to an IL-6 antigen.

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