Edible Water-Soluble Film Containing a Foam Reducing Flavoring Agent

• US 20080075825A1
• Filed: 09/20/2007
• Published: 03/27/2008
• Est. Priority Date: 09/20/2006
• Status: Active Grant

• Current Assignee: Aquestive Therapeutics, Inc.
• Original Assignee: Monosol Rx LLC (Kuraray Company Limited)
• Inventors: Fuisz, Joseph M., Fuisz, Richard C., Myers, Garry L.
• Granted Patent: US 7,972,618 B2
• Time in Patent Office: Days
• US Class Current: 426/534
• CPC Class Codes: A23L 27/79 in the form of films
• CPC Class Codes: A61K 9/006 Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
• CPC Class Codes: A61K 9/7007 Drug-containing films, membranes or sheets A61K9/0041, A61K9/0043, A61K9/006, A61K9/0063 take precedence

Abstract

An edible water-soluble film is provided. The film includes at least one water-soluble polymer, and a foam reducing flavoring agent, wherein the film is free of added anti-foaming or defoaming agents.

Claims

1. A method of preparing a substantially uniform film composition, sand method comprising:

a) preparing a film-forming composition comprising a water-soluble polymer, a foam reducing flavoring agent and a polar solvent;

b) mixing said film-forming composition under vacuum;

c) casting said film-forming composition; and

d) removing said polar solvent through a controlled drying process.

2. The method of claim 1, wherein the foam reducing flavoring agent is present in amount of about 0.1% to about 20% by weight of the film.

3. The method of claim 1, wherein the foam reducing flavoring agent is present in amount of about 0.5% to about 1.5% by weight of the film.

4. The method of claim 1, wherein the foam reducing flavoring agent is fruit or aromatic or bark based.

5. The method of claim 1, wherein the foam reducing flavoring agent is selected from the group consisting of menthol, cherry menthol, cinnamint, spearmint, peppermint, orange flavor, natural raspberry and combinations thereof.

6. The method of claim 1, wherein the foam reducing flavoring agent comprises 8 to 12 carbon atoms, at least one terminal dimethyl group, and a non-terminal OH group.

7. The method of claim 1, wherein sand substantially uniform film composition further comprises an active.