3-HYDROXYPROPIONIC ACID AND OTHER ORGANIC COMPOUNDS
First Claim
Patent Images
1. A method of making 3-hydroxypropionic acid (3-HP), comprising:
- culturing at least one cell comprising at least one exogenous nucleic acid molecule encoding at least one polypeptide that is capable of producing said 3-HP from phosphoenolpyruvate (PEP), pyruvate, or lactate under conditions such that said 3-HP is produced.
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Abstract
Methods and materials related to producing 3-HP as well as other organic compounds are disclosed. Specifically, isolated nucleic acids, polypeptides, host cells, and methods and materials for producing 3-HP and other organic compounds are disclosed.
30 Citations
25 Claims
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1. A method of making 3-hydroxypropionic acid (3-HP), comprising:
culturing at least one cell comprising at least one exogenous nucleic acid molecule encoding at least one polypeptide that is capable of producing said 3-HP from phosphoenolpyruvate (PEP), pyruvate, or lactate under conditions such that said 3-HP is produced. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A method for making 3-HP, comprising:
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contacting β
-alanine with a peptide having 4-aminobutyrate aminotransferase activity to form malonate semialdehyde; and
contacting the malonate semialdehyde with a peptide having 3-hydroxyisobutyrate dehydrogenase or 3-HP dehydrogenase activity to make 3-HP. - View Dependent Claims (22, 23, 24, 25)
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Specification