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MODIFIED SURFACES FOR THE DETECTION OF BIOMOLECULES AT THE SINGLE MOLECULE LEVEL

  • US 20080076189A1
  • Filed: 03/30/2007
  • Published: 03/27/2008
  • Est. Priority Date: 03/30/2006
  • Status: Abandoned Application
First Claim
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1. A surface composition comprising:

  • a substrate and a functionalized layer disposed on a surface thereof, an absorption layer disposed on a surface thereof, or an absorption layer disposed on a functionalized layer disposed on a surface thereof, where the functionalized layer includes sites capable of the absorption layer or capable of absorbing or binding a first molecule, molecular complex, or molecular assembly or a plurality of first molecules, complexes, assemblies or mixtures or combinations thereof where the absorption layer include sites capable of absorbing or binding the first molecule, molecular complex, or molecular assembly or the plurality of first molecules, complexes, assemblies or mixtures or combinations thereof, where each first molecule, complex and assembly includes a first fluorescent dye or fluorophore, and where the composition increases fluorescent dye or fluorophore lifetime relative to a polyelectrolyte surface.

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