Compounds and Methods for Combined Optical-Ultrasound Imaging
First Claim
1. An apparatus for combined optical-ultrasound imaging comprising an ultrasound source and a detector for the detection of emitted fluorescent light characterised in further comprising a reconstruction unit for the generation of an image from detected fluorescent light.
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Abstract
The present invention relates to novel methods and compounds for combined opticalultrasound imaging. The compounds of the present invention relate to particles comprising fluorescence donor and acceptor molecules for energy exchange via FRET. The methods of the present invention use ultrasound to modify the distance between donor and acceptor molecules present on the particles, and to consequently modify the fluorescence emitted by the donor and acceptor. The compounds and methods of the present invention are useful in medical or diagnostic imaging.
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Citations
31 Claims
- 1. An apparatus for combined optical-ultrasound imaging comprising an ultrasound source and a detector for the detection of emitted fluorescent light characterised in further comprising a reconstruction unit for the generation of an image from detected fluorescent light.
- 12. Use of a particle comprising a fluorescence donor and a fluorescence acceptor in the manufacture of a contrast agent for combined optical-ultrasound imaging.
- 14. Use of a particle comprising a fluorescence acceptor and/or a fluorescent donor for the modulation of fluorescent light emission after the application of ultrasound.
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19. A combined optical-ultrasound contrast medium characterised in comprising a particle with a fluorescence donor and/or acceptor wherein said donor or and/or acceptor are attached to the particle.
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20. A method for the manufacture of a particle for ultrasound imaging comprising:
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contacting said particle or a compound for said particle subsequently or simultaneously with fluorescence donors and/or acceptors, and reacting a fluorescence donor and/or acceptor molecule with said particle or a compound for said particle.
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21. A kit of parts for combined optical-ultrasound imaging comprising an ultrasound source, a monitor for recording fluorescent light and particles having a fluorescence acceptor and/or a fluorescent donor.
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22. A pharmaceutical composition comprising particles characterised by fluorescence acceptor and/or a fluorescence donor, said particles further comprising a pharmaceutically active compound.
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23. A method of providing an image of a body part of an individual having a contrast medium which comprises particles comprising a fluorescence donor and/or a fluorescence acceptor,
subjecting the body part to ultrasound, and recording a modulation in fluorescent light emitted by the contrast medium.
- 24. A computer based apparatus for executing a reconstruction algorithm of an image of an object from data received from an ultrasound source and detected emitted fluorescent light from a contrast medium which comprises particles comprising a fluorescence donor and/or a fluorescence acceptor, the reconstruction algorithm for the generation of the image from detected fluorescent light comprising a pressure dependent fluorescence model of the contrast medium.
- 27. A computer based method for executing a reconstruction algorithm of an image of an object from data received from an ultrasound source and detected emitted fluorescent light from a contrast medium which comprises particles comprising a fluorescence donor and/or a fluorescence acceptor, the method comprising reconstructing the image from detected fluorescent light using a pressure dependent fluorescence model of the contrast medium.
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