METHODS FOR REMOTE CHARACTERIZATION OF AN ODOR

• US 20080077331A1
• Filed: 07/11/2003
• Published: 03/27/2008
• Est. Priority Date: 05/10/1999
• Status: Active Grant

• Current Assignee: California Institute of Technology
• Original Assignee: California Institute of Technology
• Inventors: Severin, Erik, Lewis, Nathan S.
• Granted Patent: US 7,359,802 B1
• Time in Patent Office: Days
• US Class Current: 702/30
• CPC Class Codes: G01N 33/0031 comprising two or more sensors, e.g. a sensor array
• CPC Class Codes: G01N 33/0075 for multiple spatially distributed sensors, e.g. for environmental monitoring
• CPC Class Codes: Y10S 977/731 formed from a single atom, molecule, or cluster
• CPC Class Codes: Y10S 977/773 Nanoparticle, i.e. structure having three dimensions of 100 nm or less
• CPC Class Codes: Y10S 977/956 Of mechanical property
• CPC Class Codes: Y10S 977/959 Of disease state

Abstract

Provided are compositions and systems useful in remote monitoring of chemical hazards, air quality, and medical conditions, for example, robotic systems to search for and detect explosives, mines, and hazardous chemicals. In addition, the methods, systems and compositions of the invention provide the ability to mine data from a database containing a plurality of chemical fingerprints.

Claims

1. A method for remote characterization of a gaseous or vapor sample, comprising:

contacting at least one sensor with a gaseous or vapor sample, wherein the sample contains at least one analyte, the at least one sensor comprising a composite having regions of an electrically conductive material and a material compositionally different than the electrically conductive material and wherein the at least one sensor provides a detectable signal when contacted by the at least one analyte;

transmitting data corresponding to the detectable signal to a remote location via the internet, fiber-optic cable, and/or an air-wave frequency;

analyzing the data received at the remote location; and

identifying the at least one analyte present in the gaseous or vapor sample thereby characterizing the sample.

2. The method of claim 1, wherein the at least one sensor is a plurality of sensors.

3. The method of claim 2, wherein at least one other sensor is selected from the group consisting of surface acoustic wave sensors, quartz crystal resonators, metal oxide sensors, dye-coated fiber optic sensors, dye-impregnated bead arrays, micro machined cantilever arrays, composites having regions of conducting material and regions of insulating organic material, composites having regions of conducting material and regions of conducting or semi-conducting organic material, chemically-sensitive resistor or capacitor film, metal-oxide-semiconductor field effect transistors, and bulk organic conducting polymeric sensors.

4. The method of claim 1, wherein the at least one sensor is an electrically conductive sensor.

5. The method of claim 4, wherein the electrically conductive sensor comprises regions of the electrically conductive material and a material compositionally different than the electrically conductive material, wherein the sensor provides an electrical path through the regions of the electrically conductive material and the regions of the compositionally different material, and wherein the conductivity changes upon adsorption with the at least one analyte.

6. The method of claim 5, wherein at least one region of compositionally different material of one sensor is a different thickness than the region of compositionally different material of at least one other sensor.

7. The method of claim 5, wherein the compositionally different material is selected from the group consisting of polyanilines, an emeraldine salt of polyanilines, polypyrroles, polythiophenes, polyEDOTs, and derivatives thereof.

8. The method of claim 5, wherein the electrically conductive material is carbon black, Ag, Au, Pd, Cu, Ni, AuCu, or Pt.

9. The method of claim 7, wherein the sensor further comprises an insulator or plasticizer.

10. The method of claim 1, wherein the at least one sensor comprise composites having regions of the electrically conducting material and regions of a non-conducting organic material.

11. The method of claim 1, wherein the data is a digital representation of the detectable signal.

12. The method of claim 2, wherein the data is a digital profile representation of the detectable signal from each of the plurality of sensors.

13. The method of claim 1, wherein the sample is an environmental sample.

14. The method of claim 13, wherein the environmental sample is an air sample.

15. The method of claim 13, wherein the environmental sample is the headspace of a liquid sample.

16. The method of claim 1, wherein the sample is a biological sample.

17. The method of claim 16, wherein the biological sample is selected from the group consisting of a breath sample, a urine sample, a vaginal sample, a feces sample, a tissue sample and a blood sample.

18. The method of claim 16, wherein the biological sample is a breath sample.

19. The method of claim 1, wherein the data is analyzed by comparing the data to a database comprising a data profile from at least one previously-obtained detectable signal from a sample of known composition.

20. The method of claim 19, wherein the analyte in the sample is identified by matching the data to the data profile of a known composition in the database.

21. The method of claim 1, wherein the data is analyzed by comparing the data to a database containing data profiles from a plurality of detectable signals.

22. The method of claim 21, wherein each data profile in the database is associated with at least one identifier.

23. The method of claim 22, wherein the at least on identifier is selected from the group consisting of location, time, age, sex, disease state, temperature, sample source, sample type, organism, and ethnicity.

24. The method of claim 22, wherein the analyte is identified by a best match of the data to a data profile in the database and identifying any identifiers associated with the data profile.

25-54. -54. (canceled)

55. A method for remote characterization of a disease in a subject comprising:

contacting at least one sensor with a gaseous or vapor sample obtained form the subject, wherein the at least one sensor provides a detectable signal when contacted by an analyte present in the sample, the at least one sensor comprising;

regions of an electrically conductive material and regions of a material compositionally different than the electrically conductive material, and wherein the materials provide an electrical path through the regions of electrically conductive material and compositionally different material of the sensor, wherein interaction of the analyte with the sensor changes the resistance of the sensor;

electrically measuring a detectable signal of the sensor;

transmitting data corresponding to the detectable signal to a remote location via the internet, fiber-optic cable, and/or an air-wave frequency;

analyzing the data received at the remote location; and

identifying the at least one analyte present in the gaseous or vapor sample thereby characterizing the disease.

56. The method of claim 55, wherein the disease is selected from the group consisting of diabetes, liver cirrhosis, halitosis, periodontal disease, pneumonia, vaginitis, uremia, trimethylaminuria, lung cancer, dysgensia, dysosnia, cytinuria, and bacterial vaginosis.

57. The method of claim 56, wherein the analyte is an off gas of a member selected from the group consisting of Prevotella intermedia, Fusobacterium nucleatum, Porphyromonas gingivalis, Porphyromonas endodontalis, Prevotella loescheii, Hemophilus parainfluenzae, Stomatococcus muci, Treponema denticola, Veillonella species, Peptostreptococcus anaerobius, Micros prevotii, Eubacterium limosum, Centipeda periodontii, Selemonad aremidis, Eubacterium species, Bacteriodes species, Fusobacterium periodonticum, Prevotella melaninogenica, Klebsiella pneumoniae, Enterobacter cloacae, Citrobacter species and Stomatococcus mucilaginous.

58. The method of claim 55, wherein the biological sample is a subject'"'"'s breath, vaginal discharge, urine, feces, tissue sample, or blood sample.

59. (canceled)