Implantable Medical Device with Apertures for Delivery of Bioactive Agents
First Claim
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1. An implantable device for the delivery of at least two bioactive agents to a subject, the device comprising:
- a body member comprising a first set of apertures, a second set of apertures, and an inner space comprising an amount of a first bioactive agent, and an amount of a second bioactive agent, wherein, during implantation in a subject, the majority of the amount of the first bioactive agent is releasable from the device through the first set of apertures, and the majority of the amount of the second bioactive agent is releasable from the device through the second set of apertures.
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Abstract
An implantable medical device for the release of bioactive agents at desired rates is described. The device includes a body member with two or more aperture sets and an inner space. The bioactive agents are arranged within the inner space of the body member so that each bioactive agent present in the inner space is individually releasable through their respective aperture set. The aperture sets modulate the release of the bioactive agents from the body member. Arrangement of apertures and bioactive agents within the inner portion chosen to provide desired and independent release rates from the device.
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Citations
24 Claims
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1. An implantable device for the delivery of at least two bioactive agents to a subject, the device comprising:
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a body member comprising a first set of apertures, a second set of apertures, and an inner space comprising an amount of a first bioactive agent, and an amount of a second bioactive agent, wherein, during implantation in a subject, the majority of the amount of the first bioactive agent is releasable from the device through the first set of apertures, and the majority of the amount of the second bioactive agent is releasable from the device through the second set of apertures. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A method for forming an implantable bioactive agent delivery device comprising steps of:
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obtaining a body member comprising a first set of apertures, a second set of apertures, and an inner space;
providing a first bioactive agent to a portion of the inner space so the first bioactive agent is primarily releasable through the first set of apertures during implantation of the device in a subject; and
providing a second bioactive agent to a portion of the inner space so the second bioactive agent is primarily releasable through the second set of apertures during implantation of the device in a subject.
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18. A method for delivering two or more bioactive agents to a subject comprising steps of
implanting at a target location in the body an implantable bioactive agent delivery device comprising: -
a body member comprising a first set of apertures, and a second set of apertures; and
an inner space comprising a first bioactive agent, and a second bioactive agent;
wherein the first bioactive agent and the second bioactive agent are substantially unmixed in the inner space, andallowing release of the first bioactive agent through the first set of apertures and release of the second bioactive agent through the second set of apertures in the body. - View Dependent Claims (19, 20, 21, 22, 23)
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24. An implantable device for the delivery of at least two bioactive agents to a subject, the device comprising:
a body member comprising a first set of apertures, a second set of apertures, and an inner space comprising a first bioactive agent and a second bioactive agent, wherein the first bioactive agent and the second bioactive agent are substantially unmixed in the inner space, and wherein, during implantation in a subject, the first bioactive agent is releasable from the device through the first set of apertures, and the second bioactive agent is releasable from the device through the second set of apertures.
Specification