BIOCHEMICAL INSTRUMENT

• US 20080081184A1
• Filed: 09/27/2007
• Published: 04/03/2008
• Est. Priority Date: 09/29/2006
• Status: Abandoned Application

• Current Assignee: Fujifilm Corporation (Fujifilm Holdings Corporation)
• Original Assignee: Fujifilm Corporation (Fujifilm Holdings Corporation)
• Inventors: Kubo, Takashi, Nishimi, Taisei, Hoshi, Satoshi
• Application Number:
  US11/862,598
• Publication Number:
  US 20080081184A1
• Time in Patent Office: Days
• US Class Current: 428/339
• CPC Class Codes: C08J 7/0423 with at least one layer of inorganic material and at least one layer of a composition containing a polymer binder
• CPC Class Codes: C08J 7/043 Improving the adhesiveness of the coatings per se, e.g. forming primers adhesives in the form of films or foils characterised by the primer layers between the polymer carriers and the adhesives C09J7/50
• CPC Class Codes: C08J 7/056 Forming hydrophilic coatings
• CPC Class Codes: G01N 33/54373 involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
• CPC Class Codes: G01N 33/54393 Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
• CPC Class Codes: Y10T 428/269 including synthetic resin or polymer layer or component
• CPC Class Codes: Y10T 428/31507 Of polycarbonate
• CPC Class Codes: Y10T 428/31663 As siloxane, silicone or silane
• CPC Class Codes: Y10T 428/31721 Of polyimide
• CPC Class Codes: Y10T 428/31938 Polymer of monoethylenically unsaturated hydrocarbon

Abstract

It is an object of the present invention to provide a biochemical instrument wherein an adhesive layer that has hydrophilic properties, heat resistance, and satisfactory adhesiveness is provided between a plastic material surface and a hydrophilic polymer layer. The present invention provides a biochemical instrument comprising a plastic material that is coated on its surface with a hydrophilic polymer, which comprises a metal oxide thin film between the plastic material and the hydrophilic polymer layer, wherein the film stress of said metal oxide thin film is less than 5.4×10²¹ dyn/cm².

Claims

1. A biochemical instrument comprising a plastic material that is coated on its surface with a hydrophilic polymer, which comprises a metal oxide thin film between the plastic material and the hydrophilic polymer layer, wherein the film stress of said metal oxide thin film is less than 5.4×

10²¹ dyn/cm².

2. The biochemical instrument of claim 1 wherein the plastic material has a thermal expansion coefficient (K⁻

1) of 1.3 to 15×

10<sup>−

5</sup>.

3. The biochemical instrument of claim 1 wherein the plastic material is made from polymethylmethacrylate (PMMA), polycarbonate (PC), cycloolefin polymer (COP), polyethylene naphthalate (PEN), polyethylene terephthalate (PET), polypropylene (PP), polyimide (PI), liquid crystal polyester (LCP), or polydimethylsiloxane (PDMS).

4. The biochemical instrument of claim 1 wherein the metal oxide is SiO₂, Al₂O₃, TiO₂, MnO₂, MgO, SnO₂, NiO, GeO₂, or a mixture thereof.

5. The biochemical instrument of claim 1 wherein the thickness of the metal oxide film is between 10 nm and 500 nm.

6. The biochemical instrument of claim 1 wherein the hydrophilic polymer layer has a portion that inhibits adsorption of hydrophobic low-molecular-weight compounds and a portion that inhibits adsorption of biopolymers.

7. The biochemical instrument of claim 6 wherein the portion that inhibits adsorption of hydrophobic low-molecular-weight compounds is composed of an inorganic crosslinking polymer, an organic crosslinking polymer, or an organic/inorganic hybrid polymer.

8. The biochemical instrument of claim 6 wherein the portion that inhibits adsorption of hydrophobic low-molecular-weight compounds comprises a hydrolytic condensate of metal alkoxide.

9. The biochemical instrument of claim 6 wherein the portion that inhibits adsorption of biopolymers is composed of a hydrophilic polymer.

10. The biochemical instrument of claim 9 wherein the hydrophilic polymer is a non-charged hydrophilic polymer.

11. The biochemical instrument of claim 10 wherein the non-charged hydrophilic polymer is any of polyethylene glycol, polyvinylpyrrolidone, polyvinyl alcohol, poly(hydroxylalkyl)methacrylate, polyacrylamide, MPC polymer, dextran, agarose, pullulan, or polypeptide.

12. The biochemical instrument of claim 6 wherein the portion that inhibits adsorption of hydrophobic low-molecular-weight compounds and the portion that inhibits adsorption of biopolymers each have a structure represented by the following formula:

wherein Hy represents a hydrophilic polymer.

13. The biochemical instrument of claim 12 wherein Hy is any of polyethylene glycol, polyvinylpyrrolidone, polyvinyl alcohol, poly(hydroxylalkyl)methacrylate, polyacrylamide, MPC polymer, dextran, agarose, pullulan, or polypeptide.

14. The biochemical instrument of claim 1 which is obtained by coating the surface of the plastic material with a solution containing a polymer represented by formula (I) or (II) and allowing the polymer to crosslink.

(R¹)_x(OR²)_3-xSi-L₁-(A)-L₂-Si(OR³)_3-y(R⁴)_y  

 

Formula (I)

(R⁵)_z(OR⁶)_3-zSi-L₃-(B)—

R⁷  

 

Formula (II)

wherein R¹ to R⁶ each independently represent a hydrogen atom or a hydrocarbon group containing 8 or fewer carbon atoms;

R⁷ represents a hydrogen atom or a monovalent nonmetal atomic group;

x, y, and z each independently are an integer from 0 to 2;

L¹ to L³ each independently represent a divalent linking group containing 3 or more types of atoms selected from among carbon, hydrogen, oxygen, nitrogen, and sulfur atoms; and

A and B each independently represent a polymer or an oligomer having structural unit repeats.

15. A biosensor which comprises the biochemical instrument of claim 1.