Devices, vectors and methods for inducible ischemia cardioprotection
First Claim
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1. A vector system, comprising:
- a) a first vector comprising a transcriptional regulatory region which includes an organ-specific, tissue-specific or cell-specific, or energy-regulated, transcriptional regulatory element operably linked to a first open reading frame for a gene product that is unstable under normoxic conditions, stable under hypoxic conditions and binds a specific DNA sequence; and
b) a second vector comprising a transcriptional regulatory region comprising the specific DNA sequence operably linked to a second open reading frame for a therapeutic gene product, cardioprotective gene product or biomarker.
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Abstract
Vectors, systems having implantable devices and methods useful to detect or treat ischemia are provided.
171 Citations
39 Claims
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1. A vector system, comprising:
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a) a first vector comprising a transcriptional regulatory region which includes an organ-specific, tissue-specific or cell-specific, or energy-regulated, transcriptional regulatory element operably linked to a first open reading frame for a gene product that is unstable under normoxic conditions, stable under hypoxic conditions and binds a specific DNA sequence; and b) a second vector comprising a transcriptional regulatory region comprising the specific DNA sequence operably linked to a second open reading frame for a therapeutic gene product, cardioprotective gene product or biomarker. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 34, 35, 36, 37, 38, 39)
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21. A system, comprising;
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a composition comprising at least two vectors, wherein a first vector comprises a transcriptional regulatory region which includes an organ-, tissue- or cell-specific, or energy-regulated, transcriptional regulatory element operably linked to a first open reading frame for a gene product that is unstable under normoxic conditions, stable under hypoxic conditions and binds a specific DNA sequence, and wherein a second vector comprises a transcriptional regulatory region comprising the specific DNA sequence linked to a second opening reading frame for a therapeutic gene product or a cardioprotective gene product; and an implantable device adapted to deliver one or more of electrical, biologic, or drug therapy which enhances the efficacy of the therapeutic or cardioprotective gene product. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33)
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Specification