MEASUREMENT OF TISSUE ELASTIC MODULUS
First Claim
1. A method of monitoring vascular wall compliance comprising:
- measuring pulse wave velocity of the vascular wall;
measuring intramural strain of the vascular wall; and
reconstructing an elastic modulus for the vascular wall using the intramural strain and pulse wave velocity.
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Accused Products
Abstract
An optimized elastic modulus reconstruction procedure can estimate the nonlinear elastic properties of vascular wall from intramural strain and pulse wave velocity (PWV) measurements. A noninvasive free-hand ultrasound scanning procedure is used to apply external force, comparable to the force in measuring a subject'"'"'s blood pressure, to achieve higher strains by equalizing the internal arterial baseline pressure. PWV is estimated at the same location where intramural strain is measured. The reconstructed elastic modulus is optimized and the arterial elastic modulus can be determined and monitored using a simple dual elastic modulus reconstruction procedure.
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Citations
21 Claims
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1. A method of monitoring vascular wall compliance comprising:
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measuring pulse wave velocity of the vascular wall;
measuring intramural strain of the vascular wall; and
reconstructing an elastic modulus for the vascular wall using the intramural strain and pulse wave velocity. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A system for determining the vascular health of a patient comprising:
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means for measuring pulse wave velocity of a vascular wall;
means for measuring intramural strain of the vascular wall;
means for reconstructing an elastic modulus of the vascular wall using the intramural strain and pulse wave velocity measurements; and
means for comparing the reconstructed elastic modulus to the elastic moduli of diseased and healthy vascular wall. - View Dependent Claims (14, 15)
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16. A method for locating a vascular wall lesion comprising:
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measuring pulse wave velocity by longitudinal ultrasound scanning of the vascular wall, the longitudinal ultrasound scanning having proximal and distal ends; and
locating the vascular wall lesion by comparing the pulse wave velocity at proximal and distal ends of the longitudinal scan. - View Dependent Claims (17, 18, 19, 20, 21)
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Specification