Method and apparatus for diagnosing meibomian gland dysfunction

• US 20080082057A1
• Filed: 09/29/2006
• Published: 04/03/2008
• Est. Priority Date: 09/29/2006
• Status: Abandoned Application

• Current Assignee: TearScience Inc. (Johnson & Johnson)
• Original Assignee: TearScience Inc. (Johnson & Johnson)
• Inventors: Jans, John M., Korb, Donald R., Gravely, Benjamin T., Gausmann, Keith H.
• Application Number:
  US11/541,240
• Publication Number:
  US 20080082057A1
• Time in Patent Office: Days
• US Class Current: 604/289
• CPC Class Codes: A61B 3/101 for examining the tear film

Abstract

An apparatus for testing meibomian glands in the eyelids of humans for meibomian gland disease is provided. The apparatus comprises a handle, and a probe tip mounted for movement relative to said handle such that when the probe tip is placed against the eyelid and compressive force is applied, movement of the handle a preselected distance replicates the force required for natural expression of secretion from the meibomian gland. Movement of the handle relative to the probe tip the preselected distance exerts a force of between about 5 grams per 30 mm² and 40 grams per 30 mm² and preferably a force of approximately 15 grams per 30 mm². An indicator means selected from the group consisting of auditory, visual and tactile signals is provided and when activated alerts the clinician that the required force has been reached.

According to the method of the present invention a probe tip is located in contacting relation with the eyelid, the probe tip being connected to a handle. When pressure is exerted on the eyelid by pressing it against the eyelid, a preselected pressure is exerted thereon. In another embodiment of the invention, a handle having a probe tip is located on the eyelid, the probe tip is mounted for movement relative to said handle such that when the probe tip is placed against the eyelid and compressive force is applied, movement of the handle a preselected distance replicates the force required for natural expression of secretion from the meibomian gland

Claims

1. An apparatus for testing meibomian glands in the eyelids of humans for meibomian gland obstruction comprising:

a handle;

a probe tip operatively associated with said handle;

means for exerting a preselected pressure on the eyelid when the probe tip is pressed against the eyelid.

2. The apparatus according to claim 1 further including a shaft operatively associated with said handle and being connected for movement with respect to said handle and further, wherein one end of said shaft mounts said probe tip.

3. The apparatus according to claim 2 wherein said shaft is mounted for longitudinal movement within said handle.

4. The apparatus according to claim 3 wherein said means for exerting a preselected pressure comprises a constant force spring operatively associated with said shaft such that movement of the shaft exerts the constant preselected pressure upon the eyelid.

5. The apparatus according to claim 4 wherein the preselected pressure is between about 10 grams per 30 mm² and 20 grams per 30 mm².

6. The apparatus according to claim 1 wherein the preselected pressure is approximately about 15 grams per 30 mm².

7. The apparatus according to claim 5 wherein the preselected pressure is between about 5 grams per 30 mm² and 40 grams per 30 mm².

8. The apparatus according to claim 5 wherein the preselected pressure is approximately about 15 grams per 30 mm².

9. An apparatus for testing meibomian glands in the eyelids of humans for meibomian gland obstruction comprising:

a handle;

a probe tip operatively associated with said handle and adapted to be placed in contact with the eyelid;

a sensor means operatively associated with said probe tip for sensing when a preselected pressure has been exerted upon the eyelid by the probe tip when the probe tip is placed in contact with the eyelid and pressure is exerted thereon and being adapted to produce an output signal; and

indicator means for indicating when the preselected pressure has been exerted on the eyelid said indicator means being activated by said sensor means output signal.

10. The apparatus according to claim 9 wherein the preselected pressure is between about 5 grams per 40 mm² and 20 grams per 30 mm².

11. The apparatus according to claim 9 wherein the preselected pressure is approximately about 15 grams per 30 mm².

12. The apparatus according to claim 9 further including a shaft operatively associated with said handle and being connected for movement relative to said handle and further, wherein one end of said shaft mounts said probe tip.

13. The apparatus according to claim 12 wherein said shaft is mounted for longitudinal movement within said handle.

14. The apparatus according to claim 9 wherein said sensor means is selected from the group consisting of electrical contact, piezo-electric and strain gauge.

15. The apparatus according to claim 9 wherein said indicator means is selected from the group consisting of auditory, visual and tactile signals.

16. The apparatus according to claim 13 wherein the preselected pressure is between about 5 grams per 30 mm² and 40 grams per 30 mm².

17. The apparatus according to claim 13 wherein the preselected pressure is approximately about 15 grams per 30 mm².

18. The apparatus according to claim 13 further including a spring means operatively associated with said shaft and biasing said shaft out of said handle.

19. The apparatus according to claim 13 wherein said spring means is a constant force spring.

20. The apparatus according to claim 18 wherein movement of said handle a preselected distance causes compression of said spring means and in the tip exerting the preselected pressure on the meibomian gland and the sensor means activating the indicator means.

21. An apparatus for testing meibomian glands in the eyelids of humans for meibomian gland obstruction comprising:

a handle;

a probe tip operatively associated with said handle such that when the probe tip is placed against the eyelid and a preselected compressive pressure is applied, the pressure required for natural expression of secretion from the meibomian gland is replicated and a diagnosis concerning meibomian gland obstruction may be made.

22. The apparatus according to claim 21 wherein the preselected pressure applied to the eyelid is between about 5 grams per 30 mm² and 40 grams per 30 mm².

23. The apparatus according to claim 21 wherein the preselected pressure applied to the eyelid approximately 15 grams per 30 mm².

24. The apparatus according to claim 21 wherein the probe tip is connected to a shaft which is operatively associated with said handle and further, wherein said shaft is biased outward such that movement of said handle towards the meibomian gland exerts pressure upon the meibomian gland.

25. The apparatus according to claim 24 further including a spring operatively associated with said shaft and biasing said shaft outward.

26. The apparatus according to claim 23 further including indicator means for indicating when the preselected pressure is exerted on the eyelid.

27. The apparatus according to claim 26 wherein the indicator means is selected from the group consisting of auditory, visual and tactile signals.

28. A method for testing meibomian glands in the eyelids of humans for meibomian gland obstruction comprising:

locating a probe tip operatively associated with a handle in contacting relation with the eyelid; and

exerting a preselected pressure on the eyelid when the probe tip is pressed against the eyelid.

29. The method according to claim 28 further including a shaft operatively associated with the handle and being connected for movement with respect to the handle and further, wherein one end of the shaft mounts the probe tip.

30. The method according to claim 29 wherein the shaft is mounted for longitudinal movement within the handle.

31. The method according to claim 30 wherein the means for exerting a preselected pressure comprises a constant force spring operatively associates with the shaft such that movement of the shaft exerts the constant preselected pressure upon the eyelid.

32. The method according to claim 31 wherein the preselected pressure is between about 5 grams per 30 mm² and 40 grams per 30 mm².

33. The method according to claim 28 wherein the preselected pressure is approximately about 15 grams per 30 mm².

34. The method according to claim 32 wherein the preselected pressure is between about 10 grams per 30 mm² and 20 grams per 30 mm².

35. The method according to claim 32 wherein the preselected pressure is approximately about 15 grams per 30 mm².

36. A method for testing meibomian glands in the eyelids of humans for meibomian gland obstruction comprising:

locating a probe tip operatively associated with a handle and in contact with the eyelid;

sensing when a preselected pressure has been exerted upon the eyelid by the probe tip when the probe tip is placed in contact with the eyelid and pressure is exerted thereon; and

activating a user sensible signal indicating that the preselected pressure has been exerted on the eyelid.

37. The method according to claim 36 wherein the preselected pressure is between about 5 grams per 30 mm² and 40 grams per 30 mm².

38. The method according to claim 36 wherein the preselected pressure is approximately about 15 grams per 30 mm².

39. The method according to claim 36 further including a shaft operatively associated with the handle and being connected for movement relative to the handle and further, wherein one end of the shaft mounts said probe tip.

40. The method according to claim 39 wherein the shaft is mounted for longitudinal movement within the handle.

41. The method according to claim 36 wherein the sensor is selected from the group consisting of electrical contact, piezo-electric and strain gauge.

42. The method according to claim 36 wherein the user sensible signal is selected from the group consisting of auditory, visual and tactile signals.

43. The method according to claim 40 wherein the preselected pressure is between about 5 grams per 30 mm² and 40 grams per 30 mm².

44. The method according to claim 40 wherein the preselected pressure is approximately about 15 grams per 30 mm².

45. The method according to claim 40 further including a spring operatively associated with the shaft and biasing said shaft out of the handle.

46. The method according to claim 40 wherein the spring is a constant force spring.

47. The method according to claim 45 wherein movement of the handle a preselected distance causes compression of said spring means and in the tip exerting the preselected pressure on the meibomian gland and the sensor means activating the indicator means.

48. A method for testing meibomian glands in the eyelids of humans for meibomian gland obstruction comprising:

positioning a probe tip operatively associated with a handle such that when the probe tip is placed against the eyelid and a preselected compressive pressure is applied, the pressure required for natural expression of secretion from the meibomian gland is replicated and a diagnosis concerning meibomian gland obstruction may be made.

49. The method according to claim 48 wherein the preselected pressure applied to the eyelid is between about 5 grams per 30 mm² and 40 grams per 30 mm².

50. The method according to claim 48 wherein the preselected pressure applied to the eyelid approximately 15 grams per 30 mm².

51. The method according to claim 48 wherein the probe tip is connected to a shaft which is operatively associated with the handle and further, wherein the shaft is biased outward such that movement of the handle towards the meibomian gland exerts pressure upon the meibomian gland.

52. The method according to claim 51 further including a spring operatively associated with the shaft and biasing the shaft outward.

53. The method according to claim 50 further including an indicator for indicating when the preselected pressure is exerted on the eyelid.

54. The method according to claim 53 wherein the indicator is selected from the group consisting of auditory, visual and tactile signals.