Computational systems for biomedical data

• US 20080082359A1
• Filed: 12/27/2006
• Published: 04/03/2008
• Est. Priority Date: 09/29/2006
• Status: Abandoned Application

• Current Assignee: Searete LLC (Intellectual Ventures LLC)
• Original Assignee: Searete LLC A Limited Liability Corporation of The State of Delaware
• Inventors: Lord, Robert W., Jung, Edward K.Y., Levien, Royce A., Wood, Lowell L.
• Application Number:
  US11/647,533
• Publication Number:
  US 20080082359A1
• Time in Patent Office: Days
• US Class Current: 705/2
• CPC Class Codes: G06Q 10/10 Office automation; Time management
• CPC Class Codes: G16B 20/00 ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
• CPC Class Codes: G16B 20/20 Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
• CPC Class Codes: G16B 20/40 Population genetics; Linkage disequilibrium
• CPC Class Codes: G16B 25/00 ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
• CPC Class Codes: G16B 40/00 ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
• CPC Class Codes: G16B 40/30 Unsupervised data analysis
• CPC Class Codes: G16H 10/20 for electronic clinical trials or questionnaires
• CPC Class Codes: G16H 40/63 for local operation
• CPC Class Codes: G16H 50/70 for mining of medical data, e.g. analysing previous cases of other patients

Abstract

Methods, apparatuses, computer program products, devices and systems are described that accepting an input identifying a treatment target in search of an agent, the input associated with at least one query parameter; determining, based on the input, at least one subset of study data for which at least one adverse event profile associated with administration of at least one agent is acceptable within a defined limit relative to a population for which the at least one adverse event profile is unacceptable with respect to the defined limit; and presenting the agent, based on the at least one subset and the at least one query parameter.

Claims

1. A method comprising:

accepting an input identifying a treatment target in search of an agent, the input associated with at least one query parameter;

determining, based on the input, at least one subset of study data for which at least one adverse event profile associated with administration of at least one agent is acceptable within a defined limit relative to a population for which the at least one adverse event profile is unacceptable with respect to the defined limit; and

presenting the agent, based on the at least one subset and the at least one query parameter.

2. The method of claim 1 wherein accepting an input identifying a treatment target in search of an agent comprises:

accepting at least one of receiving a transmission or accepting user input identifying a treatment target in search of an agent.

6. The method of claim 1 wherein accepting an input identifying a treatment target in search of an agent, the input associated with at least one query parameter comprises:

accepting at least a statistical measure of one or more adverse events as the at least one query parameter.

10. The method of claim 1 wherein accepting an input identifying a treatment target in search of an agent, the input associated with at least one query parameter comprises:

accepting an input associated with one or more statistical filters as the at least one query parameter.

13. The method of claim 1 wherein determining, based on the input, at least one subset of study data for which at least one adverse event profile associated with administration of at least one agent is acceptable within a defined limit relative to a population for which the at least one adverse event profile is unacceptable with respect to the defined limit comprises:

determining, based on the input, at least one subset of study data for which at least one adverse event profile associated with administration of at least one agent is acceptable within a defined limit relative to at least a general population or a clinical trial population.

14. The method of claim 1 wherein determining, based on the input, at least one subset of study data for which at least one adverse event profile associated with administration of at least one agent is acceptable within a defined limit relative to a population for which the at least one adverse event profile is unacceptable with respect to the defined limit comprises:

determining, based on the input, at least one subset of study data for which at least one adverse event profile associated with administration of at least one agent is acceptable within a defined limit relative to a population for which the at least one adverse event profile is unacceptable with respect to a different defined limit.

15. The method of claim 1 wherein presenting the agent, based on the at least one subset and the at least one query parameter comprises:

presenting the agent by at least one of transmitting the agent onto a medium or displaying the agent to a user.

3-5. -5. (canceled)

7-9. -9. (canceled)

11-12. -12. (canceled)

16. A method comprising:

accepting an input identifying a treatment target in search of an agent, the input associated with at least one query parameter;

searching at least one dataset and extracting from the at least one dataset at least one subset of study data in response to said treatment target in search of an agent and said query parameter,

the at least one subset of study data including at least one subpopulation for which at least one adverse event profile associated with administration of at least one agent is acceptable within a defined limit relative to a population for which the at least one adverse event profile is unacceptable with respect to the defined limit; and

presenting the agent, based on the at least one subset and the at least one query parameter.

19. The method of claim 16 wherein extracting from the at least one dataset at least one subset of study data in response to said treatment target in search of an agent and said query parameter comprises:

extracting from the at least one dataset a subset characterized by one or more genetic parameters as the at least one subset of study data.

32. The method of claim 16 further comprising:

correlating the at least one subset of study data with subpopulation identifier data.

17-18. -18. (canceled)

20-31. -31. (canceled)

33-36. -36. (canceled)

37. A method comprising:

accepting an input identifying a treatment target in search of an agent, the input associated with at least one query parameter; and

transmitting data from the one or more user interfaces to at least one data analysis system, the data including at least the treatment target in search of an agent and the at least one query parameter;

the data analysis system being capable of identifying at least one agent for use in the context of the at least one treatment target;

the data analysis system further being capable of determining at least one subset of study data based on the input, the at least one subset including at least one subpopulation for which at least one adverse event profile associated with administration of the at least one agent is acceptable within a defined limit relative to a general population; and

the data analysis system further being capable of sending a signal to either the one or more user interfaces or a different user interface in response to the at least one subset and the at least one query parameter, which signal transmits the at least one agent.

38. A system comprising:

circuitry for accepting an input identifying a treatment target in search of an agent, the input associated with at least one query parameter;

circuitry for determining, based on the input, at least one subset of study data for which at least one adverse event profile associated with administration of at least one agent is acceptable within a defined limit relative to a population for which the at least one adverse event profile is unacceptable with respect to the defined limit; and

circuitry for presenting the agent, based on the at least one subset of study data and the at least one query parameter.

39. The system of claim 38 wherein the circuitry for accepting an input identifying a treatment target in search of an agent comprises:

circuitry for accepting at least one of receiving a transmission or accepting user input identifying a treatment target in search of an agent.

43. The system of claim 38 wherein the circuitry for accepting an input identifying a treatment target in search of an agent, the input associated with at least one query parameter comprises:

circuitry for accepting at least a statistical measure of one or more adverse events as the at least one query parameter.

44. The system of claim 38 wherein the circuitry for accepting an input identifying a treatment target in search of an agent, the input associated with at least one query parameter comprises:

circuitry for accepting at least a qualitative limit on one or more adverse events as the at least one query parameter.

45. The system of claim 38 wherein the circuitry for accepting an input identifying a treatment target in search of an agent, the input associated with at least one query parameter comprises:

circuitry for accepting at least a maximum mean incidence of one or more adverse events as the at least one query parameter.

47. The system of claim 38 wherein the circuitry for accepting an input identifying a treatment target in search of an agent, the input associated with at least one query parameter comprises:

circuitry for accepting an input associated with one or more statistical filters as the at least one query parameter.

50. The system of claim 38 wherein the circuitry for determining, based on the input, at least one subset of study data for which at least one adverse event profile associated with administration of at least one agent is acceptable within a defined limit relative to a population for which the at least one adverse event profile is unacceptable with respect to the defined limit comprises:

circuitry for determining, based on the input, at least one subset of study data for which at least one adverse event profile associated with administration of at least one agent is acceptable within a defined limit relative to at least a general population or a clinical trial population.

51. The system of claim 38 wherein the circuitry for determining, based on the input, at least one subset of study data for which at least one adverse event profile associated with administration of at least one agent is acceptable within a defined limit relative to a population for which the at least one adverse event profile is unacceptable with respect to the defined limit comprises:

circuitry for determining, based on the input, at least one subset of study data for which at least one adverse event profile associated with administration of at least one agent is acceptable within a defined limit relative to a population for which the at least one adverse event profile is unacceptable with respect to a different defined limit.

52. The system of claim 38 wherein the circuitry for presenting the agent, based on the at least one subset and the at least one query parameter comprises:

circuitry for presenting the agent by at least one of transmitting the agent onto a medium or displaying the agent to a user.

69. The system of claim 38 further comprising:

circuitry for correlating the at least one subset with subpopulation identifier data.

40-42. -42. (canceled)

46. (canceled)

48-49. -49. (canceled)

53. A system comprising:

circuitry for accepting an input identifying a treatment target in search of an agent, the input associated with at least one query parameter;

circuitry for searching at least one dataset and circuitry for extracting from the at least one dataset at least one subset of study data in response to said treatment target in search of an agent and said query parameter,

the at least one subset including at least one subpopulation for which at least one adverse event profile associated with administration of at least one agent is acceptable within a defined limit relative to a population for which the at least one adverse event profile is unacceptable with respect to the defined limit; and

circuitry for presenting the agent, based on the at least one subset and the at least one query parameter.

56. The system of claim 53 wherein the circuitry for extracting from the at least one dataset at least one subset of study data in response to said treatment target in search of an agent and said query parameter comprises:

circuitry for extracting from the at least one dataset a subset characterized by one or more genetic parameters as the at least one subset.

63. The system of claim 53 wherein the circuitry for extracting from the at least one dataset at least one subset of study data in response to said treatment target in search of an agent and said query parameter comprises:

circuitry for extracting from the at least one dataset a subset characterized by one or more demographic parameters as the at least one subset.

64. The system of claim 53 wherein the circuitry for extracting from the at least one dataset at least one subset of study data in response to said treatment target in search of an agent and said query parameter comprises:

circuitry for extracting from the at least one dataset a subset characterized by one or more, of age, gender, ethnicity, race, liver enzyme genotype, or medical history as the at least one subset.

65. The system of claim 53 wherein the circuitry for extracting from the at least one dataset at least one subset of study data in response to said treatment target in search of an agent and said query parameter comprises:

circuitry for extracting from the at least one dataset a subset characterized by one or more of lifestyle, exercise regimen, diet, nutritional regimen, dietary supplementation, concomitant medical therapy, or concomitant alternative medical therapy as the at least one subset.

54-55. -55. (canceled)

57-62. -62. (canceled)

66-68. -68. (canceled)

70-73. -73. (canceled)

74. A system comprising:

circuitry for accepting an input identifying a treatment target in search of an agent, the input associated with at least one query parameter; and

circuitry for transmitting data from the one or more user interfaces to at least one data analysis system, the data including at least the treatment target in search of an agent and the at least one query parameter;

the data analysis system being capable of identifying at least one agent for use in the context of the at least one treatment target;

the data analysis system further being capable of determining at least one subset of study data based on the input, the at least one subset including at least one subpopulation for which at least one adverse event profile associated with administration of the at least one agent is acceptable within a defined limit relative to a general population; and

the data analysis system further being capable of sending a signal to either the one or more user interfaces or a different user interface in response to the at least one subset and the at least one query parameter, which signal transmits the at least one agent.

75. A computer program product comprising:

a signal-bearing medium bearing

(a) one or more instructions for accepting an input identifying a treatment target in search of an agent, the input associated with at least one query parameter;

(b) one or more instructions for determining, based on the input, at least one subset of study data for which at least one adverse event profile associated with administration of at least one agent is acceptable within a defined limit relative to a population for which the at least one adverse event profile is unacceptable with respect to the defined limit; and

(c) one or more instructions for presenting the agent, based on the at least one subset and the at least one query parameter.

76. The computer program product of claim 75, wherein the signal-bearing medium includes a computer-readable medium.

77. The computer program product of claim 75, wherein the signal-bearing medium includes a recordable medium.

78. The computer program product of claim 75, wherein the signal-bearing medium includes a communications medium.

79. A system comprising:

a computing device; and

instructions that when executed on the computing device cause the computing device to

(a) accept an input identifying a treatment target in search of an agent, the input associated with at least one query parameter;

(b) determine, based on the input, at least one subset of study data for which at least one adverse event profile associated with administration of at least one agent is acceptable within a defined limit relative to a population for which the at least one adverse event profile is unacceptable with respect to the defined limit; and

(c) present the agent, based on the at least one subset and the at least one query parameter.

80. The system of claim 79 wherein the computing device comprises:

one or more of a personal digital assistant (PDA), a laptop computer, a tablet personal computer, a networked computer, a computing system comprised of a cluster of processors, a computing system comprised of a cluster of servers, a workstation computer, and/or a desktop computer.

81. The system of claim 79 wherein the computing device is operable to receive information regarding the subset of the at least one dataset and to present the at least one agent from at least one memory.