Computational systems for biomedical data

• US 20080082367A1
• Filed: 07/26/2007
• Published: 04/03/2008
• Est. Priority Date: 09/29/2006
• Status: Abandoned Application

• Current Assignee: Brigham and Women's Hospital Incorporated, Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: Searete LLC (Intellectual Ventures LLC)
• Inventors: Lord, Robert W., Jung, Edward K.Y., Levien, Royce A., Wood, Lowell L.
• Application Number:
  US11/881,802
• Publication Number:
  US 20080082367A1
• Time in Patent Office: Days
• US Class Current: 705/3
• CPC Class Codes: G06Q 10/00 Administration; Management
• CPC Class Codes: G16H 50/20 for computer-aided diagnosis, e.g. based on medical expert systems
• CPC Class Codes: G16H 70/60 relating to pathologies

Abstract

Methods, apparatuses, computer program products, devices and systems are described that carry out accepting an input identifying at least one allergy, accessing data containing at least one innate determinant associated with the at least one allergy, and accessing data containing at least one acquired determinant associated with the at least one allergy; and presenting a signal related to ingestion-dependent allergy information associated with a defined level of the at least one allergy in response to accessing data containing at least one innate determinant associated with the at least one allergy, and accessing data containing at least one acquired determinant associated with the at least one allergy.

Claims

1-32. -32. (canceled)

33. A method comprising:

accepting an input identifying at least one ingested agent associated with an allergic reaction;

accessing a dataset to identify at least one innate determinant of the allergic reaction in a population;

identifying at least one test determinant of the allergic reaction in the population;

determining, based on the innate and test determinants, at least one subpopulation for which the allergic reaction associated with administration of the at least one ingested agent is unacceptable within a defined limit relative to a population for which the allergic reaction associated with administration of the at least one agent is acceptable with respect to the defined limit; and

presenting a signal related to the at least one subpopulation in response to determining, based on the innate and test determinants, the at least one subpopulation.

76. The method of claim 33 wherein accepting an input identifying at least one ingested agent associated with an allergic reaction comprises:

accepting an input identifying at least one ingested agent associated with at least a Type I immediate hypersensitivity reaction, a Type II cytotoxic hypersensitivity reaction, a Type III immune-complex reaction, or a Type IV delayed hypersensitivity reaction.

77. The method of claim 33 wherein accepting an input identifying at least one ingested agent associated with an allergic reaction comprises:

accepting an input identifying at least one ingested agent associated with a hypersensitivity reaction that does not fall within the Type I-IV Gell and Coombs allergy classification system.

78. The method of claim 33 wherein accepting an input identifying at least one ingested agent associated with an allergic reaction comprises:

accepting an input identifying at least one ingested agent associated with at least one of a drug allergy or a nutraceutical allergy.

79. The method of claim 33 wherein accepting an input identifying at least one ingested agent associated with an allergic reaction comprises:

accepting an input identifying at least one ingested agent associated with at least one of a drug allergy or a nutraceutical allergy.

80. The method of claim 33 wherein accepting an input identifying at least one ingested agent associated with an allergic reaction comprises:

accepting an input identifying at least one ingested agent associated with a food allergy or a chemical allergy.

81. The method of claim 33 wherein accepting an input identifying at least one ingested agent associated with an allergic reaction comprises:

accepting an input identifying at least one ingested agent associated with a multiple chemical sensitivity allergy.

82. The method of claim 33 wherein accepting an input identifying at least one ingested agent associated with an allergic reaction comprises:

accepting an input identifying at least one ingested agent associated with at least one of an antibiotic allergy, an insulin allergy, a sulpha drug allergy, an aspirin allergy, an NSAID allergy, a beta blocker allergy, a chemotherapeutic allergy, a vaccine allergy, an anesthetic allergy, or an anti-convulsant allergy.

83. The method of claim 33 wherein accepting an input identifying at least one ingested agent associated with an allergic reaction comprises:

accepting an input identifying at least one ingested agent associated with at least one of a peanut allergy, a milk allergy, an egg allergy, a tree nut allergy, a fish allergy, a shellfish allergy, a soy allergy, a corn allergy, or a wheat allergy.

84. The method of claim 33 wherein accepting an input identifying at least one ingested agent associated with an allergic reaction comprises:

accepting an input identifying at least one ingested agent associated with at least a latex allergy.

85. The method of claim 33 wherein accepting an input identifying at least one ingested agent associated with an allergic reaction comprises:

accepting an input identifying at least one ingested agent associated with at least one of a thimerosal allergy, a formaldehyde allergy, a phenol allergy, a sulfite allergy, a glycerine allergy, a hydrocarbon allergy, a pesticide allergy, a metal allergy, or a fertilizer allergy.

86. The method of claim 33 wherein accessing a dataset to identify at least one innate determinant of the allergic reaction in a population comprises:

accessing data containing at least one genetic, epigenetic, or gene expression determinant associated with the at least one allergy as the at least one innate determinant.

87. The method of claim 33 wherein accessing a dataset to identify at least one innate determinant of the allergic reaction in a population comprises:

accessing data containing at least one single nucleotide polymorphism, haplotype, or other DNA sequence determinant associated with the at least one allergy as the at least one innate determinant.

88. The method of claim 33 wherein accessing a dataset to identify at least one innate determinant of the allergic reaction in a population comprises:

accessing at least one of clinical trial data or medical history data containing the at least one innate determinant of the allergic reaction in a population.

89. The method of claim 33 wherein identifying at least one test determinant of the allergic reaction in the population comprises:

identifying at least one specific IgE determinant of the allergic reaction in the population.

90. The method of claim 33 wherein identifying at least one test determinant of the allergic reaction in the population comprises:

identifying at least one total IgE determinant of the allergic reaction in the population.

91. The method of claim 33 wherein identifying at least one test determinant of the allergic reaction in the population comprises:

identifying at least one T-cell, B-cell, mast cell, basophil, eosinophil, or peripheral blood mononuclear cell determinant of the allergic reaction in the population.

92. The method of claim 33 wherein determining, based on the innate and test determinants, at least one subpopulation for which the allergic reaction associated with administration of the at least one ingested agent is unacceptable within a defined limit relative to a population for which the allergic reaction associated with administration of the at least one agent is acceptable with respect to the defined limit comprises:

determining, based on the innate and test determinants, at least one ethnic subpopulation for which the allergic reaction associated with administration of the at least one ingested agent is unacceptable within a defined limit relative to a population for which the allergic reaction associated with administration of the at least one agent is acceptable with respect to the defined limit.

93. The method of claim 33 wherein determining, based on the innate and test determinants, at least one subpopulation for which the allergic reaction associated with administration of the at least one ingested agent is unacceptable within a defined limit relative to a population for which the allergic reaction associated with administration of the at least one agent is acceptable with respect to the defined limit comprises:

determining, based on the innate and test determinants, at least one genetic subpopulation for which the allergic reaction associated with administration of the at least one ingested agent is unacceptable within a defined limit relative to a population for which the allergic reaction associated with administration of the at least one agent is acceptable with respect to the defined limit.

94. The method of claim 33 wherein determining, based on the innate and test determinants, at least one subpopulation for which the allergic reaction associated with administration of the at least one ingested agent is unacceptable within a defined limit relative to a population for which the allergic reaction associated with administration of the at least one agent is acceptable with respect to the defined limit comprises:

determining, based on the innate and test determinants, at least one geographic subpopulation for which the allergic reaction associated with administration of the at least one ingested agent is unacceptable within a defined limit relative to a population for which the allergic reaction associated with administration of the at least one agent is acceptable with respect to the defined limit.

95. The method of claim 33 wherein presenting a signal related to the at least one subpopulation in response to determining, based on the innate and test determinants, the at least one subpopulation comprises:

presenting at least one subpopulation at a user interface in response to determining, based on the innate and test determinants, the at least one subpopulation.

34-66. -66. (canceled)

67. A system comprising:

means for accepting an input identifying at least one ingested agent associated with an allergic reaction;

means for accessing a dataset to identify at least one innate determinant of the allergic reaction in a population;

means for identifying at least one test determinant of the allergic reaction in the population;

means for determining, based on the innate and test determinants, at least one subpopulation for which the allergic reaction associated with administration of the at least one ingested agent is unacceptable within a defined limit relative to a population for which the allergic reaction associated with administration of the at least one agent is acceptable with respect to the defined limit; and

means for presenting a signal related to the at least one subpopulation in response to the at least one subpopulation.

96. The system of claim 67 wherein the means for accepting an input identifying at least one ingested agent associated with an allergic reaction comprises:

means for accepting an input identifying at least one ingested agent associated with at least a Type I immediate hypersensitivity reaction, a Type II cytotoxic hypersensitivity reaction, a Type III immune-complex reaction, or a Type IV delayed hypersensitivity reaction.

97. The system of claim 67 wherein the means for accepting an input identifying at least one ingested agent associated with an allergic reaction comprises:

means for accepting an input identifying at least one ingested agent associated with a hypersensitivity reaction that does not fall within the Type I-IV Gell and Coombs allergy classification system.

98. The system of claim 67 wherein the means for accepting an input identifying at least one ingested agent associated with an allergic reaction comprises:

means for accepting an input identifying at least one ingested agent associated with at least one of a drug allergy or a nutraceutical allergy.

99. The system of claim 67 wherein the means for accepting an input identifying at least one ingested agent associated with an allergic reaction comprises:

means for accepting an input identifying at least one ingested agent associated with at least one of a drug allergy or a nutraceutical allergy.

100. The system of claim 67 wherein the means for accepting an input identifying at least one ingested agent associated with an allergic reaction comprises:

means for accepting an input identifying at least one ingested agent associated with a food allergy or a chemical allergy.

101. The system of claim 67 wherein the means for accepting an input identifying at least one ingested agent associated with an allergic reaction comprises:

means for accepting an input identifying at least one ingested agent associated with a multiple chemical sensitivity allergy.

102. The system of claim 67 wherein the means for accepting an input identifying at least one ingested agent associated with an allergic reaction comprises:

means for accepting an input identifying at least one ingested agent associated with at least one of an antibiotic allergy, an insulin allergy, a sulpha drug allergy, an aspirin allergy, an NSAID allergy, a beta blocker allergy, a chemotherapeutic allergy, a vaccine allergy, an anesthetic allergy, or an anti-convulsant allergy.

103. The system of claim 67 wherein the means for accepting an input identifying at least one ingested agent associated with an allergic reaction comprises:

means for accepting an input identifying at least one ingested agent associated with at least one of a peanut allergy, a milk allergy, an egg allergy, a tree nut allergy, a fish allergy, a shellfish allergy, a soy allergy, a corn allergy, or a wheat allergy.

104. The system of claim 67 wherein the means for accepting an input identifying at least one ingested agent associated with an allergic reaction comprises:

means for accepting an input identifying at least one ingested agent associated with at least a latex allergy.

105. The system of claim 67 wherein the means for accepting an input identifying at least one ingested agent associated with an allergic reaction comprises:

means for accepting an input identifying at least one ingested agent associated with at least one of a thimerosal allergy, a formaldehyde allergy, a phenol allergy, a sulfite allergy, a glycerine allergy, a hydrocarbon allergy, a pesticide allergy, a metal allergy, or a fertilizer allergy.

106. The system of claim 67 wherein the means for accepting an input identifying at least one ingested agent associated with an allergic reaction comprises:

means for accepting an input identifying at least one ingested agent associated with at least one of a thimerosal allergy, a formaldehyde allergy, a phenol allergy, a sulfite allergy, a glycerine allergy, a hydrocarbon allergy, a pesticide allergy, a metal allergy, or a fertilizer allergy.

107. The system of claim 67 wherein the means for accessing a dataset to identify at least one innate determinant of the allergic reaction in a population comprises:

means for accessing data containing at least one genetic, epigenetic, or gene expression determinant associated with the at least one allergy as the at least one innate determinant.

108. The system of claim 67 wherein the means for accessing a dataset to identify at least one innate determinant of the allergic reaction in a population comprises:

means for accessing data containing at least one single nucleotide polymorphism, haplotype, or other DNA sequence determinant associated with the at least one allergy as the at least one innate determinant.

109. The system of claim 67 wherein the means for accessing a dataset to identify at least one innate determinant of the allergic reaction in a population comprises:

means for accessing at least one of clinical trial data or medical history data containing the at least one innate determinant of the allergic reaction in a population.

110. The system of claim 67 wherein the means for identifying at least one test determinant of the allergic reaction in the population comprises:

means for identifying at least one specific IgE determinant of the allergic reaction in the population.

111. The system of claim 67 wherein the means for identifying at least one test determinant of the allergic reaction in the population comprises:

means for identifying at least one total IgE determinant of the allergic reaction in the population.

112. The system of claim 67 wherein the means for identifying at least one test determinant of the allergic reaction in the population comprises:

means for identifying at least one T-cell, B-cell, mast cell, basophil, eosinophil, or peripheral blood mononuclear cell determinant of the allergic reaction in the population.

113. The system of claim 67 wherein the means for determining, based on the innate and test determinants, at least one subpopulation for which the allergic reaction associated with administration of the at least one ingested agent is unacceptable within a defined limit relative to a population for which the allergic reaction associated with administration of the at least one agent is acceptable with respect to the defined limit comprises:

means for determining, based on the innate and test determinants, at least one ethnic subpopulation for which the allergic reaction associated with administration of the at least one ingested agent is unacceptable within a defined limit relative to a population for which the allergic reaction associated with administration of the at least one agent is acceptable with respect to the defined limit.

114. The system of claim 67 wherein the means for determining, based on the innate and test determinants, at least one subpopulation for which the allergic reaction associated with administration of the at least one ingested agent is unacceptable within a defined limit relative to a population for which the allergic reaction associated with administration of the at least one agent is acceptable with respect to the defined limit comprises:

means for determining, based on the innate and test determinants, at least one genetic subpopulation for which the allergic reaction associated with administration of the at least one ingested agent is unacceptable within a defined limit relative to a population for which the allergic reaction associated with administration of the at least one agent is acceptable with respect to the defined limit.

115. The system of claim 67 wherein the means for determining, based on the innate and test determinants, at least one subpopulation for which the allergic reaction associated with administration of the at least one ingested agent is unacceptable within a defined limit relative to a population for which the allergic reaction associated with administration of the at least one agent is acceptable with respect to the defined limit comprises:

means for determining, based on the innate and test determinants, at least one geographic subpopulation for which the allergic reaction associated with administration of the at least one ingested agent is unacceptable within a defined limit relative to a population for which the allergic reaction associated with administration of the at least one agent is acceptable with respect to the defined limit.

116. The system of claim 67 wherein the means for presenting a signal related to the at least one subpopulation in response to the at least one subpopulation comprises:

means for presenting at least one subpopulation at a user interface in response to the at least one subpopulation.

68-75. -75. (canceled)

117. A computer program product comprising:

a signal-bearing medium bearing

(a) one or more instructions for accepting an input identifying at least one ingested agent associated with an allergic reaction;

(b) one or more instructions for accessing a dataset to identify at least one innate determinant of the allergic reaction in a population;

(c) one or more instructions for identifying at least one test determinant of the allergic reaction in the population;

(d) one or more instructions for determining, based on the innate and test determinants, at least one subpopulation for which the allergic reaction associated with administration of the at least one ingested agent is unacceptable within a defined limit relative to a population for which the allergic reaction associated with administration of the at least one agent is acceptable with respect to the defined limit; and

(e) one or more instructions for presenting a signal related to the at least one subpopulation in response to determining, based on the innate and test determinants, the at least one subpopulation.

118. The computer program product of claim 117, wherein the signal-bearing medium includes a computer-readable medium.

119. The computer program product of claim 117, wherein the signal-bearing medium includes a recordable medium.

120. The computer program product of claim 117, wherein the signal-bearing medium includes a communications medium.

121. A system comprising:

a computing device; and

instructions that when executed on the computing device cause the computing device to

(a) accept an input identifying at least one ingested agent associated with an allergic reaction

(b) access a dataset to identify at least one innate determinant of the allergic reaction in a population;

(c) identify at least one test determinant of the allergic reaction in the population;

(d) determine, based on the innate and test determinants, at least one subpopulation for which the allergic reaction associated with administration of the at least one ingested agent is unacceptable within a defined limit relative to a population for which the allergic reaction associated with administration of the at least one agent is acceptable with respect to the defined limit; and

(e) present a signal related to the at least one subpopulation in response to the at least one subpopulation.

122. The system of claim 121 wherein the computing device comprises:

one or more of a personal digital assistant (PDA), a laptop computer, a tablet personal computer, a networked computer, a computing system comprised of a cluster of processors, a computing system comprised of a cluster of servers, a workstation computer, and/or a desktop computer.

123. The system of claim 121 wherein the computing device is operable to

(a) receive information regarding the at least one ingested agent associated with an allergic reaction;

(b) receive information regarding the at least one innate determinant of the allergic reaction in a population; and

(c) present the at least one subpopulation from at least one memory.