Computational systems for biomedical data

• US 20080082500A1
• Filed: 09/29/2006
• Published: 04/03/2008
• Est. Priority Date: 09/29/2006
• Status: Active Grant

• Current Assignee: Travera, LLC
• Original Assignee: Searete LLC (Intellectual Ventures LLC)
• Inventors: Lord, Robert W., Jung, Edward K.Y., Levien, Royce A., Wood, Lowell L.
• Granted Patent: US 10,546,652 B2
• Time in Patent Office: Days
• US Class Current: 707/3
• CPC Class Codes: G16H 10/20 for electronic clinical trials or questionnaires

Abstract

An apparatus, device, methods, computer program product, and system are described that accept an input defining at least one medical condition; identify within one or more sets of study data at least one agent having a defined level of efficacy in treating the at least one medical condition; identify at least one subpopulation having a defined tolerance for at least one adverse event associated with administration of the at least one agent, the at least one subpopulation exhibiting at least some defined level of efficacy upon administration of the at least one agent to the subpopulation; and present the at least one agent in response to said identification of the at least one subpopulation.

Claims

1-29. -29. (canceled)

30. A system comprising:

means for accepting an input defining at least one medical condition;

means for identifying within one or more sets of study data at least one agent having a defined level of efficacy in treating the at least one medical condition;

means for identifying at least one subpopulation having a defined tolerance for at least one adverse event associated with administration of the at least one agent, the at least one subpopulation exhibiting at least some defined level of efficacy upon administration of the at least one agent to the subpopulation; and

means for presenting the at least one agent responsive to said means for identifying at least one subpopulation.

31. The system of claim 30 wherein the means for accepting an input defining at least one medical condition, comprises:

means for accepting an input defining at least one chronic medical condition.

32. The system of claim 30 wherein the means for accepting an input defining at least one chronic medical condition, comprises:

means for accepting an input defining at least one of an arthritis condition, a cancer condition, a cardiovascular condition, an impotence condition, an obesity condition, an infectious condition, or a diabetes condition.

33. The system of claim 30 wherein the means for identifying within one or more sets of study data at least one agent having a defined level of efficacy in treating the at least one medical condition, comprises:

means for identifying at least one agent that is reported to have a defined level of efficacy in treating the at least one medical condition.

34. The system of claim 30 wherein the means for identifying within one or more sets of study data at least one agent having a defined level of efficacy in treating the at least one medical condition, comprises:

means for identifying at least one agent having a defined level of efficacy in treating the at least one medical condition from within two or more sets of study data.

35. The system of claim 30 wherein the means for identifying within one or more sets of study data at least one agent having a defined level of efficacy in treating the at least one medical condition, comprises:

means for identifying within one or more sets of study data at least one FDA-approved drug having a defined level of efficacy in treating the at least one medical condition.

36. The system of claim 30 wherein the means for identifying within one or more sets of study data at least one agent having a defined level of efficacy in treating the at least one medical condition, comprises:

means for identifying within one or more sets of study data at least one FDA-approved biologic having a defined level of efficacy in treating the at least one medical condition.

37. The system of claim 30 wherein the means for identifying within one or more sets of study data at least one agent having a defined level of efficacy in treating the at least one medical condition, comprises:

means for identifying within one or more sets of study data at least one metabolite having a defined level of efficacy in treating the at least one medical condition.

38. The system of claim 30 wherein the means for identifying within one or more sets of study data at least one agent having a defined level of efficacy in treating the at least one medical condition, comprises:

means for identifying within one or more sets of study data at least one prodrug having a defined level of efficacy in treating the at least one medical condition.

39. The system of claim 30 wherein the means for identifying within one or more sets of study data at least one agent having a defined level of efficacy in treating the at least one medical condition, comprises:

means for searching at least one database having data corresponding to the one or more sets of study data; and

means for extracting from the at least one database the at least one agent having the defined level of efficacy in treating the at least one medical condition responsive to said means for searching.

40. The system of claim 39 wherein the means for searching at least one database having data corresponding to the one or more sets of study data, comprises:

means for searching at least a Physicians'"'"' Desk Reference database.

41. The system of claim 39 wherein the means for extracting from the at least one database the at least one agent having the defined level of efficacy in treating the at least one medical condition responsive to said means for searching, comprises:

means for extracting from the at least one database at least one anti-cancer agent.

42. The system of claim 30 wherein the means for identifying at least one subpopulation having a defined tolerance for at least one adverse event associated with administration of the at least one agent, comprises:

means for searching at least one database having data corresponding to the one or more sets of study data; and

means for extracting the at least one subpopulation having a defined tolerance for at least one adverse event associated with administration of the at least one agent from the at least one database responsive to said means for searching.

43. The system of claim 42 wherein the means for searching at least one database having data corresponding to the one or more sets of study data, comprises:

means for searching at least the Adverse Event Reporting System database maintained by the United States Food and Drug Administration.

44. The system of claim 42 wherein the means for extracting the at least one subpopulation having a defined tolerance for at least one adverse event associated with administration of the at least one agent from the at least one database responsive to said means for searching, comprises:

means for extracting from the at least one database a subpopulation characterized by one or more genetic parameters.

45. The system of claim 42 wherein the means for extracting the at least one subpopulation having a defined tolerance for at least one adverse event associated with administration of the at least one agent from the at least one database responsive to said means for searching, comprises:

means for extracting from the at least one database a subpopulation characterized by one or more epigenetic parameters.

46. The system of claim 42 wherein the means for extracting the at least one subpopulation having a defined tolerance for at least one adverse event associated with administration of the at least one agent from the at least one database responsive to said means for searching, comprises:

means for extracting from the at least one database a subpopulation characterized by one or more biochemical parameters.

47. The system of claim 42 wherein the means for extracting the at least one subpopulation having a defined tolerance for at least one adverse event associated with administration of the at least one agent from the at least one database responsive to said means for searching, comprises:

means for extracting from the at least one database a subpopulation characterized by one or more gene expression parameters.

48. The system of claim 42 wherein the means for extracting the at least one subpopulation having a defined tolerance for at least one adverse event associated with administration of the at least one agent from the at least one database responsive to said means for searching, comprises:

means for extracting from the at least one database a subpopulation characterized by one or more protein expression parameters.

49. The system of claim 42 wherein the means for extracting the at least one subpopulation having a defined tolerance for at least one adverse event associated with administration of the at least one agent from the at least one database responsive to said means for searching, comprises:

means for extracting from the at least one database a subpopulation characterized by one or more behavioral parameters.

50. The system of claim 42 wherein extracting the at least one subpopulation having a defined tolerance for at least one adverse event associated with administration of the at least one agent from the at least one database responsive to said means for searching, comprises:

means for extracting from the at least one database a subpopulation characterized by one or more physiologic parameters.

51. The system of claim 42 wherein the means for extracting the at least one subpopulation having a defined tolerance for at least one adverse event associated with administration of the at least one agent from the at least one database responsive to said means for searching, comprises:

means for extracting from the at least one database a subpopulation characterized by one or more demographic parameters.

52. The system of claim 42 wherein the means for extracting the at least one subpopulation having a defined tolerance for at least one adverse event associated with administration of the at least one agent from the at least one database responsive to said means for searching, comprises:

means for extracting from the at least one database a subpopulation characterized by one or more of age, gender, ethnicity, race, or medical history.

53. The system of claim 42 wherein the means for extracting the at least one subpopulation having a defined tolerance for at least one adverse event associated with administration of the at least one agent from the at least one database responsive to said means for searching, comprises:

means for extracting from the at least one database a subpopulation characterized by one or more of lifestyle, exercise regimen, diet, nutritional regimen, dietary supplementation, concomitant medical therapy, or concomitant alternative medical therapy.

54. The system of claim 42 wherein the means for extracting the at least one subpopulation having a defined tolerance for at least one adverse event associated with administration of the at least one agent from the at least one database responsive to said means for searching, comprises:

means for extracting from the at least one database a subpopulation characterized by one or more of linkage disequilibrium analysis profile, haplotype profile, single nucleotide polymorphism profile, or individual genetic sequence profile.

55. The system of claim 42 wherein the means for identifying at least one subpopulation having a defined tolerance for at least one adverse event associated with administration of the at least one agent, comprises:

means for extracting from the at least one database at least one subpopulation having a significantly lower incidence of at least one adverse event than that of at least one reported clinical trial for the at least one agent.

56. The system of claim 30 wherein the at least one subpopulation exhibiting at least some defined level of efficacy upon administration of the at least one agent to the subpopulation comprises:

at least one subpopulation exhibiting at least the defined level of efficacy found within the one or more sets of study data.

57. The system of claim 30 wherein the means for presenting the at least one agent responsive to said means for identifying at least one subpopulation, comprises:

means for presenting the at least one subpopulation and the at least one agent.

58. A computer program product comprising:

a signal-bearing medium bearing

(a) one or more instructions for accepting an input defining at least one medical condition;

(b) one or more instructions for identifying within one or more sets of study data at least one agent having a defined level of efficacy in treating the at least one medical condition;

(c) one or more instructions for identifying at least one subpopulation having a defined tolerance for at least one adverse event associated with administration of the at least one agent, the at least one subpopulation exhibiting at least some defined level of efficacy upon administration of the at least one agent to the subpopulation; and

(d) one or more instructions for presenting the at least one agent in response to said identifying at least one subpopulation.

59. A system comprising:

circuitry for accepting an input defining at least one medical condition;

circuitry for identifying within one or more sets of study data at least one agent having a defined level of efficacy in treating the at least one medical condition;

circuitry for identifying at least one subpopulation having a defined tolerance for at least one adverse event associated with administration of the at least one agent, the at least one subpopulation exhibiting at least some defined level of efficacy upon administration of the at least one agent to the subpopulation; and

circuitry for presenting the at least one agent in response to said identifying at least one subpopulation.

60. A method comprising:

accepting an input defining at least one treatment goal;

identifying within one or more sets of study data at least one agent having a defined level of efficacy in addressing the at least one treatment goal;

identifying at least one subpopulation having a defined tolerance for at least one adverse event associated with administration of the at least one agent, the at least one subpopulation exhibiting at least some defined level of efficacy upon administration of the at least one agent to the subpopulation; and

presenting the at least one agent in response to said identifying at least one subpopulation.

61. A system comprising:

means for accepting an input defining at least one treatment goal;

means for identifying within one or more sets of study data at least one agent having a defined level of efficacy in addressing the at least one treatment goal;

means for identifying at least one subpopulation having a defined tolerance for at least one adverse event associated with administration of the at least one agent, the at least one subpopulation exhibiting at least some defined level of efficacy upon administration of the at least one agent to the subpopulation; and

means for presenting the at least one agent in response to said identifying at least one subpopulation.

62. The system of claim 61 comprising:

means for correlating the at least one subpopulation with subpopulation identifier data; and

means for presenting the at least one agent and the subpopulation identifier data.

63. A computer program product comprising:

a signal-bearing medium bearing

(a) one or more instructions for accepting an input defining at least one treatment goal;

(b) one or more instructions for identifying within one or more sets of study data at least one agent having a defined level of efficacy in treating the at least one treatment goal;

(c) one or more instructions for identifying at least one subpopulation having a defined tolerance for at least one adverse event associated with administration of the at least one agent, the at least one subpopulation exhibiting at least some defined level of efficacy upon administration of the at least one agent to the subpopulation; and

(d) one or more instructions for presenting the at least one agent in response to said identifying at least one subpopulation.

64. A system comprising:

circuitry for accepting an input defining at least one treatment goal;

circuitry for identifying within one or more sets of study data at least one agent having a defined level of efficacy in addressing the at least one treatment goal;

circuitry for identifying at least one subpopulation having a defined tolerance for at least one adverse event associated with administration of the at least one agent, the at least one subpopulation exhibiting at least some defined level of efficacy upon administration of the at least one agent to the subpopulation; and

circuitry for presenting the at least one agent in response to said identifying at least one subpopulation.