METHODS FOR REDUCTION OF POST OPERATIVE ILEUS.

• US 20080085296A1
• Filed: 09/18/2007
• Published: 04/10/2008
• Est. Priority Date: 10/06/2006
• Status: Abandoned Application

• Current Assignee: Ethicon Endo-Surgery, Inc. (Johnson & Johnson)
• Original Assignee: Ethicon Endo-Surgery, Inc. (Johnson & Johnson)
• Inventors: Murray, Michael A., Powell, Darrel M., Shurtleff, Carl J., Pomeroy, Mark
• Application Number:
  US11/856,765
• Publication Number:
  US 20080085296A1
• Time in Patent Office: Days
• US Class Current: 424/423
• CPC Class Codes: A61F 2/02 Prostheses implantable into the body closure means for urethra or rectum or for artificial body openings therefor A61F2/0004
• CPC Class Codes: A61K 31/55 having seven-membered rings, e.g. azelastine, pentylenetetrazole
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system

Abstract

An apparatus and method for reducing post-operative ileus and/or gastric stasis is described. The method can include applying to the intestine a therapeutically effective amount of a composition comprising a drug that is effective in reducing post-operative ileus and/or gastric stasis, such as by introducing the composition through a surgical access device, such as a trocar or endoscope. The apparatus can include a sheet of material, a surgical fastener, or a buttress comprising the composition.

Claims

1. A method for reducing post-operative ileus comprising:

providing an applier including a composition comprising a drug that is effective in reducing post-operative ileus;

introducing the applier to an interior portion of the body through a channel of a surgical access device; and

applying the composition to an internal portion of the body.

2. The method of claim 1, wherein the drug is selected from the group consisting of a mast cell degranulation inhibitor, galantamine, and a non-steroidal anti-inflammatory drug.

3. The method of claim 1, wherein the surgical access device comprises a trocar.

4. The method of claim 1, wherein the surgical access device comprises an endoscope.

5. The method of claim 1, wherein the step of applying includes spraying a powder comprising the drug.

6. The method of claim 1, wherein the applier is introduced to through a natural orifice of a body.

7. The method of claim 1, wherein the applier includes a sheet comprising the drug.

8. The method of claim 7, wherein at least a predetermined portion of the sheet does not include the drug.

9. The method of claim 1 wherein the step of applying comprises applying the composition to a portion of the gastro-intestinal tract.

10. The method of claim 1 wherein the step of applying comprises applying a gel.

11. The method of claim 1 wherein the step of applying comprises compressing a reservoir containing the composition.

12. A method for reducing post-operative ileus, the method comprising:

providing a composition comprising a drug that is effective in reducing post-operative ileus;

introducing the composition through a natural orifice of a body; and

applying the composition to a portion of the intestine.

13. The method of claim 12 comprising applying the composition introduced through the natural orifice to an outer surface of the intestine.

14. The method of claim 12 wherein the composition is introduced trans-anally.

15. The method of claim 12 wherein the composition is introduced transorally.

16. The method of claim 12 comprising the steps of:

introducing an endoscope into the intestinal tract;

forming an opening in the intestinal tract;

directing the composition through the endoscope;

directing the composition through the opening in the intestinal tract; and

applying the composition to the serosa of the intestine.

17. The method of claim 16 comprising spraying the composition on the intestine.