Multi-Phase Release Potassium Guaiacolsulfonate Compositions
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Accused Products
Abstract
Formulations have been developed administering a guaiacolsulfonate salt, preferably potassium salt, in multi-phases. In a preferred embodiment, the formulation contains potassium guaiacolsulfonate in an immediate release (“IR”) form and a sustained or delayed release (“DR”) form and/or pulsed release (“PR”) form. In another embodiment, the potassium guaiacolsulfonate is released in a gradient, decreasing the side effects associated with rapidly elevated blood levels. In another embodiment, the drug is bound to an ion-exchange resin, which can be suspended in a liquid or incorporated into a matrix for delayed, sustained and/or pulsed release. Dosage unit forms may be tablets, gels, liquids, capsules, beads, microparticles, films or lozenges. Multi-phase delivery can also be achieved through the use of a kit that provides for dosage escalation. The formulations are useful in the treatment of one or more symptoms of coughs, colds, sinusitis and other respiratory illnesses. The formulations are also useful in the treatment or relief of fibromyalgia, pain, and Irritable Bowel Syndrome
19 Citations
40 Claims
- 1. A multi-phase guaiacolsulfonate salt formulation.
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38. The method of claim 64 comprising providing medication dosages in blister packs or pouches, organized into event modules associated with particular daily events, and having corresponding event indicia.
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39. The method of claim 64, wherein the event modules are further organized into day modules having day indicia.
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40. The method of claim 64, wherein the event modules are organized into compartments of a box.
Specification