Emissive compositions with internal standard and related techniques
First Claim
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1. A particle, comprising:
- a core,an outer layer at least partially encapsulating the core, wherein the outer layer comprises a polymer material having a first emission upon exposure to a set of conditions, anda species having a second emission upon exposure to said set of conditions, wherein the species is integrally connected to at least a portion of the particle.
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Abstract
The present invention provides materials, devices, and methods related to determination of an analyte. In some embodiments, an analyte may be determined by monitoring, for example, a change in an optical signal of a luminescent material (e.g., particle) upon exposure to an analyte. The present invention may be particularly advantageous in that some embodiments may comprise an emissive species useful as an internal reference standard. Methods of the invention may also be useful in the quantitative determination of an analyte. In some cases, the present invention may allow for selective determination of an analyte.
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Citations
159 Claims
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1. A particle, comprising:
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a core, an outer layer at least partially encapsulating the core, wherein the outer layer comprises a polymer material having a first emission upon exposure to a set of conditions, and a species having a second emission upon exposure to said set of conditions, wherein the species is integrally connected to at least a portion of the particle. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. A particle, comprising:
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a core, an outer layer at least partially encapsulating the core, wherein the outer layer comprises a polymer material having an emission, and a support material integrally connected to at least a portion of the particle such that the particle is substantially contained within the support material. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56)
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57. A particle, comprising:
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a polymer material having a first emission upon exposure to a set of conditions, and a species having a second emission upon exposure to said set of conditions, wherein a characteristic of the first emission is affected by an analyte for determination by the particle, and the second emission is essentially unaffected by the analyte.
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58. A sensor, comprising:
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a particle comprising a core comprising a polymeric material and an outer layer at least partially encapsulating the core, wherein the outer layer comprises an emissive polymer material; a source of energy applicable to the particle to cause an emission of radiation; and an emission detector positioned to detect the emission. - View Dependent Claims (59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89)
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90. A method for determination of an analyte, comprising:
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providing a particle having an emission, wherein the particle comprises a core and an outer layer at least partially encapsulating the core, wherein the outer layer comprises an emissive polymer material; exposing the particle to a sample suspected of containing an analyte wherein the analyte, if present, interacts with the particle to produce a change in the emission of the particle; and determining the change in the emission of the particle, thereby determining the analyte. - View Dependent Claims (91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124)
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125. A method for quantitative determination of the concentration of an analyte, comprising:
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providing a particle comprising a polymer material and a species, wherein, upon exposure to a set of conditions, the polymer material has a first emission and the species has a second emission, wherein the maximum of the first emission and the maximum of the second emission are separated by at least 50 nm; determining a first ratio between a characteristic of the first emission and a characteristic of the second emission; exposing the particle to an analyte, wherein the analyte interacts with the polymer material to produce a third emission; determining, upon exposure to said set of conditions, a second ratio between a characteristic of the second emission and a characteristic of the third emission, wherein the second ratio is different than the first ratio; and determining the difference between the first ratio and the second ratio, thereby quantitatively determining the concentration of the analyte. - View Dependent Claims (126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153, 154, 155, 156, 157, 158, 159)
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Specification