Combinatorial complex carbohydrate libraries and methods for the manufacture and uses thereof
First Claim
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1. A method diagnosing a disease, a disorder or a condition characterized by elicitation of antibodies against a carbohydrate structure, the method comprising:
- (a) providing an addressable carbohydrate library, wherein said addressable carbohydrate library comprises a plurality of carbohydrate structures each being attached at a specific and addressable location of a single solid support, wherein each of said plurality of carbohydrate structures is composed of monosaccharide residues, such that a stereo-specificity of each bond interconnecting said monosaccharide residues is defined by said addressable location on said single solid support;
(b) reacting the addressable carbohydrate library with antibodies derived from a patient suspected of having the disease, disorder or condition to thereby generate a pattern of locations to which the antibodies bind, such that by comparing the pattern with a known pattern a diagnosis of the disease, disorder or condition is obtainable.
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Abstract
A combinatorial complex carbohydrate library is provided and including a plurality of addressable complex carbohydrate structures.
25 Citations
41 Claims
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1. A method diagnosing a disease, a disorder or a condition characterized by elicitation of antibodies against a carbohydrate structure, the method comprising:
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(a) providing an addressable carbohydrate library, wherein said addressable carbohydrate library comprises a plurality of carbohydrate structures each being attached at a specific and addressable location of a single solid support, wherein each of said plurality of carbohydrate structures is composed of monosaccharide residues, such that a stereo-specificity of each bond interconnecting said monosaccharide residues is defined by said addressable location on said single solid support;
(b) reacting the addressable carbohydrate library with antibodies derived from a patient suspected of having the disease, disorder or condition to thereby generate a pattern of locations to which the antibodies bind, such that by comparing the pattern with a known pattern a diagnosis of the disease, disorder or condition is obtainable. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41)
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Specification
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Current AssigneeGlycominds, Ltd. (Storage Drop Storage Technologies Ltd.)
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Original AssigneeGlycominds, Ltd. (Storage Drop Storage Technologies Ltd.)
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InventorsDukler, Avinoam, Dotan, Nir
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Application NumberUS11/896,717Publication NumberTime in Patent OfficeDaysField of SearchUS Class Current506/9CPC Class CodesC07B 2200/11 Compounds covalently bound ...C07H 15/02 Acyclic radicals, not subst...C07H 15/203 Monocyclic carbocyclic ring...C07K 14/59 Follicle-stimulating hormon...C40B 30/04 by measuring the ability to...G01N 2333/42 Lectins, e.g. concanavalin,...G01N 2400/02 involving antibodies to sug...G01N 2400/10 Polysaccharides, i.e. havin...G01N 33/5308 for analytes not provided f...G01N 33/543 with an insoluble carrier f...G01N 33/66 involving blood sugars, e.g...G01N 33/6842 Proteomic analysis of subse...G01N 33/6845 Methods of identifying prot...
