SMALL MOLECULE POTENTIATOR OF HORMONAL THERAPY FOR BREAST CANCER
First Claim
1. A method of treating estrogen receptor positive breast cancer, the method comprising the step of administering to a subject a therapeutically effective amount of an HDAC inhibitor in combination with a course of hormonal therapy, wherein the HDAC inhibitor is not valproic acid.
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Abstract
The present application demonstrates that HDAC inhibitors can be used in combination with hormonal therapy to treat and prevent estrogen receptor positive breast cancer. HDAC inhibitors can also be combined with IGF-1R inhibitors, mTOR inhibitors, and EGFR inhibitors to treat breast cancer, optionally in combination with hormonal therapy if indicated. Combinations of the compounds, with or without HDAC inhibitors, and with or without hormonal therapy, can also be used. The invention therefore provides methods of treatment and pharmaceutical compositions.
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Citations
87 Claims
- 1. A method of treating estrogen receptor positive breast cancer, the method comprising the step of administering to a subject a therapeutically effective amount of an HDAC inhibitor in combination with a course of hormonal therapy, wherein the HDAC inhibitor is not valproic acid.
- 28. A pharmaceutical composition comprising a therapeutically effective amount of an HDAC inhibitor in combination with a therapeutically effective amount of a hormonal therapy compound, wherein the HDAC inhibitor is not valproic acid.
- 46. A method of preventing estrogen receptor positive breast cancer, the method comprising the step of administering to a subject a therapeutically effective amount of an HDAC inhibitor in combination with a course of anti-estrogen therapy or estrogen ablation therapy.
- 57. A method of treating breast cancer, the method comprising the step of administering to a subject a therapeutically effective amount of an HDAC inhibitor in combination with a therapeutically effective amount of at least one compound selected from the group consisting of an IGF-1R inhibitor, an mTOR inhibitor, and an EGFR inhibitor, wherein the HDAC inhibitor is not valproic acid when the compound is an EGFR inhibitor.
- 63. A pharmaceutical composition comprising a therapeutically effective amount of an HDAC inhibitor in combination with a therapeutically effective amount of at least one compound selected from the group consisting of an IGF-1R inhibitor, an mTOR inhibitor, and an EGFR inhibitor, wherein the HDAC inhibitor is not valproic acid when the compound is an EGFR inhibitor.
- 74. A method of treating estrogen receptor positive breast cancer, the method comprising the step of administering to a subject a therapeutically effective amount of an HDAC inhibitor in combination with a course of hormonal therapy and one or more additional active ingredients effective to treat estrogen receptor positive breast cancer in the combination.
- 82. A pharmaceutical composition comprising a therapeutically effective amount of an HDAC inhibitor in combination with a therapeutically effective amount of a hormonal therapy compound and one or more additional active ingredients.
Specification