CRYSTALLINE FORMS OF RAPAMYCIN ANALOGS
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Abstract
A rapamycin analog composition includes a crystalline form of a rapamycin analog. The crystal can be a hydrate, dehydrate, solvate, or desolvate. The rapamycin analog can have a structure of Formula 1, which is optionally a prodrug, salt, derivative, or combination thereof:
53 Citations
104 Claims
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1-79. -79. (canceled)
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80. A rapamycin analog composition comprising:
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a crystalline form of a rapamycin analog having a structure of Formula 1, or a prodrug, salt, derivative, or combination thereof of the rapamycin analog;
- View Dependent Claims (81, 82, 83, 84, 85, 86)
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87. A pharmaceutical rapamycin analog composition comprising:
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a pharmaceutically acceptable carrier; and
a therapeutically effective amount of a crystalline form of a rapamycin analog having a structure of Formula 1 contained within the pharmaceutically acceptable carrier, or a prodrug, salt, derivative, or combination thereof of the rapamycin analog;
- View Dependent Claims (88, 89, 90, 91, 92, 93)
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94. A crystalline rapamycin analog comprising:
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a crystalline form of a rapamycin analog having a structure of Formula 1, or a prodrug, salt, derivative, or combination thereof of the rapamycin analog, wherein the crystalline form is a solvate or desolvate of the rapamycin analog;
- View Dependent Claims (95, 96, 97, 98)
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99. A crystalline rapamycin analog comprising:
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a solvate crystal having at least a portion of a crystal lattice consisting of a solvent and a rapamycin analog having a structure of Formula 2, or a prodrug, salt, derivative, or combination thereof of the rapamycin analog;
- View Dependent Claims (100, 101)
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102. A crystalline rapamycin analog comprising:
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a desolvate crystal having at least a portion of a crystal lattice consisting of a rapamycin analog having a structure of Formula 2, or a prodrug, salt, derivative, or combination thereof of the rapamycin analog;
- View Dependent Claims (103, 104)
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Specification