ANALYTE SENSOR

• US 20080086042A1
• Filed: 03/26/2007
• Published: 04/10/2008
• Est. Priority Date: 10/04/2006
• Status: Active Grant

• Current Assignee: DexCom Incorporated
• Original Assignee: DexCom Incorporated
• Inventors: Brister, Mark, Petisce, James R., Woo, Kum Ming, Saint, Sean, Shults, Mark, Leach, Jacob S., Wong, David K.
• Granted Patent: US 7,775,975 B2
• Time in Patent Office: Days
• US Class Current: 600/347
• CPC Class Codes: A61B 2560/0223 of calibration, e.g. protocols for calibrating sensors
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61B 5/412 Detecting or monitoring sepsis
• CPC Class Codes: A61B 5/6848 Needles
• CPC Class Codes: A61B 5/6849 in combination with a needle set
• CPC Class Codes: A61M 2230/201 Glucose concentration
• CPC Class Codes: A61M 5/14 Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
• CPC Class Codes: A61M 5/16804 Flow controllers
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00

Abstract

Systems and methods of use for continuous analyte measurement of a host'"'"'s vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host'"'"'s circulatory system.

Claims

1. A system for measuring an analyte, the system comprising:

a vascular access device configured to be in communication with a circulatory system of a host;

an analyte sensor configured to reside within the vascular access device, wherein the analyte sensor is configured to measure a concentration of an analyte within the circulatory system; and

a flow control device.

2. The system of claim 1, wherein the flow control device comprises a valve.

3. The system of claim 2, wherein the valve comprises a first discreet position and a second discreet position.

4. The system of claim 3, wherein the valve is configured to move between the first position and the second position over a time period of from about 0.5 seconds to about 10.0 seconds.

5. The system of claim 3, further comprising tubing fluidly connected to the valve, wherein the valve is configured to meter a flow through the tubing at a predetermined flow rate.

6. The system of claim 5, wherein the predetermined flow rate is from about 0.001 ml/min to about 2.0 ml/min.

7. The system of claim 6, wherein the predetermined flow rate flow rate is from about 0.02 ml/min to about 0.35 ml/min.

8. The system of claim 3, further comprising tubing connected to the valve, wherein the valve is configured such that about 500 microliters or less of a fluid passes through the tubing during movement of the valve between the first position and the second position.

9. The system of claim 8, wherein the system is configured to push fluid through the tubing during movement of the valve from the first position to the second position.

10. The system of claim 9, wherein the system is configured to draw back a sample into the tubing during movement of the valve from the second position to the first position.

11. The sample of claim 8, wherein the valve is configured such that about 50 microliters or less of a fluid passes through the tubing during the movement of the valve between the first position and the second position.

12. The system of claim 1, further comprising a bag containing a fluid.

13. The system of claim 12, further comprising a flow regulator configured to regulate a flow of the fluid.

14. The system of claim 1, further comprising a local analyzer.

15. The system of claim 14, wherein the local analyzer comprises a potentiostat.

16. The system of claim 14, wherein the local analyzer comprises a data processing module.

17. The system of claim 14, wherein the local analyzer comprises a data storage module.

18. The system of claim 1, further comprising a remote analyzer.

19. The system of claim 18, wherein the remote analyzer comprises a touch screen.

20. The system of claim 18, wherein the remote analyzer is configured to control the flow control device.

21. The system of claim 18, wherein the remote analyzer is detachably operably connected to a local analyzer.

22. The system of claim 18, wherein the remote analyzer comprises a data processing module.

23. The system of claim 18, wherein the remote analyzer comprises a data storage module.

24. The system of claim 18, wherein the flow control device comprises a processor configured to control the flow control device, and wherein the processor is operably connected to the remote analyzer.

25. The system of claim 1, wherein the flow control device comprises a pump.