MICRODEVICE FOR DETECTING, ACTIVATING AND DELIVERING MOLECULES
First Claim
1. An implantable microdevice for at least one of in situ delivering, detecting, and activating one or more samples in a subject, the implantable microdevice comprising:
- a microdialysis probe comprising an input end, an output end, an inner volume and a dialysis membrane, wherein the dialysis membrane encloses and defines the inner volume, the input end and the output end extend to the inner volume, the input end is operatively couplable to a sample transporter for delivering a flow-in sample to the inner volume, and the output end is operatively couplable to an assay system for detecting a biological parameter from a flow-out sample; and
an energy conductor coupled to the microdialysis probe for transmitting and receiving at least one of energy and a signal to and from at least one of a sample within the inner volume and a biological tissue surrounding the inner volume, wherein the energy conductor has a first end that is operatively couplable to an energy source, and a second end that is operatively couplable to a signal detection system.
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Accused Products
Abstract
An implantable microdevice for investigating the efficiency of site-specific drug delivery, as well as real-time on-site evaluation of the endogenous or exogenous compounds as a result of the specific physiological stress/changes is described. The unique arrangement of the implantable microdevice makes it possible to carry out several diagnostic and therapeutic tasks concurrently, with or without additional functional coupling to other components or devices. Also described is a microdevice for in situ applying and/or monitoring a photodynamic therapy in a subject and methods of using the microdevice. A system for in situ delivering, detecting, and/or activating one or more samples in a subject is also described.
13 Citations
25 Claims
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1. An implantable microdevice for at least one of in situ delivering, detecting, and activating one or more samples in a subject, the implantable microdevice comprising:
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a microdialysis probe comprising an input end, an output end, an inner volume and a dialysis membrane, wherein the dialysis membrane encloses and defines the inner volume, the input end and the output end extend to the inner volume, the input end is operatively couplable to a sample transporter for delivering a flow-in sample to the inner volume, and the output end is operatively couplable to an assay system for detecting a biological parameter from a flow-out sample; and an energy conductor coupled to the microdialysis probe for transmitting and receiving at least one of energy and a signal to and from at least one of a sample within the inner volume and a biological tissue surrounding the inner volume, wherein the energy conductor has a first end that is operatively couplable to an energy source, and a second end that is operatively couplable to a signal detection system. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A microdevice for at least one of in situ applying and monitoring a photodynamic therapy in a subject, the microdevice comprising:
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a microdialysis probe comprising an input end, an output end, an inner volume and a dialysis membrane, wherein the dialysis membrane encloses and defines the inner volume, the input end and the output end extend to the inner volume, the input end is operatively couplable to a syringe pump for delivering a flow-in sample comprising an photoactivatable compound to the inner volume and a target tissue adjacent to the inner volume, and the output end is operatively couplable to an assay system for detecting a biological parameter from a flow-out sample; and one or more optical fibers coupled to the microdialysis probe for transmitting photon energy to activate the photoactivatable compound in at least one of the inner volume and the target tissue and receiving one or more signals from at least one of the target tissue and the photoactivatable compound, wherein the one or more optical fibers have a first end that is operatively couplable to an energy source, and a second end that is operatively couplable to a signal detection system. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22)
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23. A system for at least one of in situ delivering, detecting, and/or activating one or more samples in a subject, the system comprising:
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a microdialysis probe comprising an input end, an output end, an inner volume and a dialysis membrane, wherein the dialysis membrane encloses and defines the inner volume, the input end and the output end extend to the inner volume; an energy conductor coupled to the microdialysis probe for transmitting and receiving at least one of energy and a signal to and from at least one of a sample within the inner volume and a biological tissue surrounding the inner volume; and a signal detection system coupled to the output end of the microdialysis probe and an end of the energy conductor. - View Dependent Claims (24, 25)
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Specification