System and Related Methods for Monitoring Cardiac Disease Using Pacing Latency Measurements

• US 20080086177A1
• Filed: 10/09/2006
• Published: 04/10/2008
• Est. Priority Date: 10/09/2006
• Status: Abandoned Application

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Inventors: Gill, Jong, Min, Xiaoyi, Levine, Paul A.
• Application Number:
  US11/539,824
• Publication Number:
  US 20080086177A1
• Time in Patent Office: Days
• US Class Current: 607/25
• CPC Class Codes: A61B 5/0809 by impedance pneumography
• CPC Class Codes: A61B 5/091 Measuring volume of inspired or expired gases, e.g. to determine lung capacity
• CPC Class Codes: A61B 5/11 Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb for measuring pulse A61B5/02 ;A61B5/1038 takes precedence; motion detection to correct for motion artifacts in physiological signals A61B5/721
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61N 1/3621 for treating or preventing abnormally high heart rate
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/37 Monitoring; Protecting

Abstract

A system and related methods for monitoring cardiac disease. The system includes an implantable medical device having a microcontroller that is configured to measure a pacing latency value for a region of a heart, compare the measured pacing latency value to a previously measured pacing latency value for the region of the heart, and determine a change in an amount of cardiac disease in the region of the heart based on the comparison of the measured pacing latency values.

Claims

1. A method for monitoring cardiac disease, the method comprising:

a. measuring a pacing latency value for a region of a heart;

b. comparing the measured pacing latency value to a previously measured pacing latency value for the region of the heart; and

c. determining a cardiac disease condition based on the comparison of the measured pacing latency values.

2. The method according to claim 1, wherein the previously measured pacing latency value is calculated from an average of a plurality of previously measured latency values.

3. The method according to claim 1, further comprising reconfirming the measured pacing latency value if the measured pacing latency value is different from the previously measured pacing latency value.

4. The method according to claim 1, further comprising notifying a medical practitioner of the change of cardiac disease.

5. The method according to claim 1, wherein:

a. the step of measuring the pacing latency value for the region of the heart includes;

i. measuring a first pacing latency value for an atrium, and

ii. measuring a second pacing latency value for a ventricle;

b. the step of comparing the measured pacing latency value to the previously measured pacing latency value for the region of the heart includes;

i. comparing the measured first pacing latency value to a previously measured first pacing latency value for the atrium, and

ii. comparing the measured second pacing latency value to a previously measured second pacing latency value for the ventricle; and

c. the step of determining the change in the amount of cardiac disease in the region of the heart based on the comparison of the pacing latency values includes determining a change in the amount of cardiac disease in the region of the heart based on both the comparison of the first pacing latency values for the atrium and the comparison of the second pacing latency values for the ventricle.

6. The method according to claim 1, further comprising:

a. measuring a heart failure surrogate value; and

b. characterizing an amount of cardiac disease for the heart based on a combination of the measured heart failure surrogate value and the comparison of the pacing latency values.

7. The method according to claim 1, wherein:

a. the step of measuring the pacing latency value for the region of the heart includes;

i. measuring a first pacing latency value for a left ventricle, and

ii. measuring a second pacing latency value for a right ventricle;

b. the step of comparing the measured pacing latency value to the previously measured pacing latency value for the region of the heart includes;

i. comparing the measured first pacing latency value to a previously measured first pacing latency value for the left ventricle, and

ii. comparing the measured second pacing latency value to a previously measured second pacing latency value for the right ventricle; and

c. the step of determining the change in the amount of cardiac disease in the region of the heart based on the comparison of the pacing latency values includes determining a change in ventricular remodeling based on both the comparison of the first pacing latency values and the comparison of the second pacing latency values.

8. The method according to claim 1, wherein the region of the heart is selected from the group consisting of a left atrium, a left ventricle, a right atrium, and a right ventricle.

9. An implantable medical device comprising:

a microcontroller that is adapted to measure a pacing latency value in a region of a heart, and to determine a cardiac disease condition in the region of the heart based on a comparison of the measured pacing latency value to a previously measured pacing latency value.

10. The implantable medical device according to claim 9, wherein the microcontroller is configured to measure a heart failure surrogate value, and to characterize an amount of cardiac disease for the heart based on a combination of the measured heart failure surrogate value and the comparison of the measured pacing latency values.

11. The implantable medical device according to claim 9, wherein the implantable medical device is configured to notify a medical practitioner of the change in the amount of cardiac disease in the region of the heart.

12. The implantable medical device according to claim 11, wherein the medical practitioner is notified of the change in the amount of cardiac disease in the region of the heart when an absolute change in the measured pacing latency value or a relative change in the measured pacing latency value is greater than or equal to a predetermined threshold value.

13. A system comprising:

means for measuring a pacing latency value for a region of a heart;

means for comparing the measured pacing latency value to a previously measured pacing latency value for the region of the heart; and

means for determining a cardiac disease condition based on the comparison of the measured pacing latency values.

14. The system according to claim 13, further comprising means for generating a notification signal of the cardiac disease condition.