Biodegradable ocular implants and methods for treating ocular conditions
First Claim
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1. A biodegradable implant for delivery of a bioactive agent to the interior of the eye, wherein the implant comprises a matrix comprising a biodegradable polymer and a bioactive agent which is capable of releasing a therapeutically effective amount of bioactive agent in the interior of the eye after a period of 30 days from implantation.
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Abstract
Biodegradable ocular implants are described. The ocular implants include a bioactive agent that can be released within the eye to treat an ocular condition or indication. The implants can be used for the administration of a bioactive agent over prolonged periods of time. In some aspects the implants are formed of a matrix of natural biodegradable polysaccharides.
91 Citations
25 Claims
- 1. A biodegradable implant for delivery of a bioactive agent to the interior of the eye, wherein the implant comprises a matrix comprising a biodegradable polymer and a bioactive agent which is capable of releasing a therapeutically effective amount of bioactive agent in the interior of the eye after a period of 30 days from implantation.
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17. A method for administering a bioactive agent to the inner eye, the method comprising the steps of:
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providing a biodegradable implant comprising a matrix comprising a biodegradable polymer and a bioactive agent, wherein the implant is configured so that it can be placed at a location in the inner eye using a sutureless surgical procedure, implanting the implant in the inner eye, and maintaining the implant in the inner eye, wherein the implant releases a therapeutically useful amount of bioactive agent in the inner eye after a period of 30 days from the step of implanting. - View Dependent Claims (18, 19, 20, 21)
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22. A method for administering a bioactive agent to the inner eye, the method comprising the steps of:
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providing a biodegradable implant comprising a matrix of natural biodegradable polysaccharides and a bioactive agent, and implanting the implant in the interior of the eye, wherein the implant releases a therapeutically useful amount of bioactive agent in the inner eye.
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23. A bioactive agent-releasing biodegradable ocular implant comprising a matrix of natural biodegradable polysaccharides and bioactive agent within the matrix.
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24. A kit for placing a biodegradable implant in the inner eye, the kit comprising:
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a biodegradable implant comprises a matrix comprising a biodegradable polymer and a bioactive agent which is capable of releasing a therapeutically effective amount of bioactive agent in the inner eye after a period of 30 days from implantation, and an insertion instrument to provide the implant to a target site within the inner eye. - View Dependent Claims (25)
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Specification