Tissue engineering in vivo with vascularized scaffolds

• US 20080090292A1
• Filed: 10/09/2007
• Published: 04/17/2008
• Est. Priority Date: 10/13/2006
• Status: Active Grant

• Current Assignee: Biostruxs LLC
• Original Assignee: BCN Biosciences LLC
• Inventors: Brooks, Mai Nguyen, Watson, James P.
• Granted Patent: US 7,846,728 B2
• Time in Patent Office: Days
• US Class Current: 435/395
• CPC Class Codes: A61K 35/12 Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells vaccines or medicinal preparations containing antigens or antibodies A61K39/00
• CPC Class Codes: C12N 2533/40 Polyhydroxyacids, e.g. polymers of glycolic or lactic acid (PGA, PLA, PLGA); Bioresorbable polymers
• CPC Class Codes: C12N 5/0653 Adipocytes; Adipose tissue

Abstract

The field of the present invention relates to a novel method for producing tissue or organ in a mammal by implanting in vivo a novel three dimensional biodegradable scaffold. The novel three dimensional biodegradable scaffolds overcome the barrier of developing large organs with tissue engineering.

Claims

1. A novel three dimensional scaffold, said scaffold comprising a biodegradable or non-degradable polymer;

wherein said scaffold is designed to accommodate multiple layers of omentum.

2. The scaffold of claim 1, wherein the outer shape of said scaffold is altered according to the shape of the organ for which it is to be implanted.

3. The scaffold of claim 1, further comprising a subcutaneous port for the subsequent administration of additional materials, said materials selected from the group consisting of cells, nutrients, and drugs.

4. A procedure of implanting a three dimensional biodegradable scaffold in vivo, wherein said procedure comprises creating a growth chamber and wherein said growth chamber is selected from the group consisting of subcutaneous growth chambers, intra-thoracic growth chambers and intra-abdominal growth chambers.

5. The procedure of claim 4, wherein said growth chamber comprises a resorbable, transferable shell.

6. The procedure of claim 4, wherein said growth chamber is a subcutaneous growth chamber.

7. The procedure of claim 4, wherein said growth chamber is an intra-thoracic growth chamber.

8. The procedure of claim 4, wherein said growth chamber is an intra-abdominal growth chamber.

9. The procedure of claim 4, further comprising transposing said scaffold to a particular organ.

10. A method of implanting cells into a three dimensional biodegradable scaffold.

11. A method of claim 10, wherein said cells may be suspended in a matrix containing growth factors.

12. A method of claim 10, wherein said cells may be derived from a cell source selected from the group consisting of an autologous cell source, donor cells, cultured cells, stem cells, or genetically engineered cells.