SURGICAL PROSTHESIS HAVING BIODEGRADABLE AND NONBIODEGRADABLE REGIONS

• US 20080091222A1
• Filed: 12/05/2007
• Published: 04/17/2008
• Est. Priority Date: 02/27/2003
• Status: Abandoned Application

• Current Assignee: MAST Biosurgery AG
• Original Assignee: MAST Biosurgery AG
• Inventors: Deusch, Kai, Mullins, Kenton, Calhoun, Christopher
• Application Number:
  US11/951,049
• Publication Number:
  US 20080091222A1
• Time in Patent Office: Days
• US Class Current: 606/151
• CPC Class Codes: A61F 2/0063 Implantable repair or support meshes, e.g. hernia meshes
• CPC Class Codes: A61F 2/0077 Special surfaces of prostheses, e.g. for improving ingrowth A61F2/30767 takes precedence
• CPC Class Codes: A61F 2210/0004 bioabsorbable
• CPC Class Codes: A61F 2250/0051 differing in tissue ingrowth capacity, e.g. made from both ingrowth-promoting and ingrowth-preventing parts
• CPC Class Codes: Y10T 156/10 Methods of surface bonding and/or assembly therefor

Abstract

A prosthesis for repairing a hernia includes an adhesion-resistant biodegradable region and an opposing tissue-ingrowth biodegradable region. When the prosthesis is implanted into the patient, the adhesion-resistant biodegradable region covers a fascial defect of the hernia, and the tissue-ingrowth biodegradable region is located above the adhesion-resistant biodegradable region while being exposed substantially only to the host'"'"'s subcutaneous tissue layer. This orientation allows the tissue-ingrowth biodegradable region to become firmly incorporated with the host'"'"'s body tissue. The adhesion-resistant biodegradable region faces the internal organs and decreases the incidence of adhesions and/or bowel obstruction.

Claims

1. An improved implantable prosthetic reinforcement device for tissue, the device comprising:

a structural component providing reinforcement;

a hydrophilic surface component providing tissue compatibility; and

through-holes passing through the device and being of sufficient size to allow through-growth of the tissue that is being reinforced;

wherein the spacing of the through-holes is selected to minimize fibrotic stimulation.

2. The device of claim 1, wherein the structural component is selected from a woven fabric or mesh, a non-woven fabric or mesh, a knitted fabric or mesh, an embedded dispersed fibrillar component in the surface component, and a perforated or non-perforated sheet of polymeric material.

3. The device of claim 1, wherein the through-holes are made after the combination of the hydrophilic surface component and the structural component.

4. The device of claim 1, wherein the through-holes are made before the combination of the hydrophilic surface component and the structural component.

5. The device of claim 1, wherein the through-holes are formed in a repeating pattern in the device.

6. The device of claim 5, wherein the pattern is selected to provide sufficient compartmentalization of the device along its planar dimensions to restrict the growth of microbial colonies.

7. The device of claim 5, further providing a portion of an antimicrobial material disposed in each repeat or compartment of the pattern of the device.

8. The device of claim 5, wherein the area of the repeating pattern is less than about 25 square millimeters.

9. The device of claim 1, wherein the hydrophilic surface component is applied to the structural component by spraying.

10. The device of claim 9, wherein the surface component is applied in an organic solvent which is removed by drying.

11. The device of claim 1, wherein the hydrophilic surface component is applied to the structural component by coating a liquid hydrophilic surface component onto a preformed structural component.

12. The device of claim 1, wherein the hydrophilic surface component and the structural component are mixed and then spread out to form a film.

13. The device of claim 1, wherein the hydrophilic surface component is partially cured during or after its application to the structural component by admixture with a compound promoting curing of the hydrophilic surface component.

14. The device of claim 13, wherein the compound promoting curing comprises one or more of an aqueous solution and a polyol.

15. The device of claim 13, wherein the compound promoting curing comprises atmospheric moisture.

16. Use of the device of claim 1 for the treatment of one or more of a hernia or herniation of an internal organ;

an aneurysm or prolapse of an internal organ;

or of a rectocele, enterocele, cystocele, enterocystocele, or traumatic wound.